公开(公告)号：US09889131B2

公开(公告)日：2018-02-13

申请号：US15017040

申请日：2016-02-05

Applicant: Georgetown University

Inventor： Stephen W. Byers ,  Sivanesan Dakshanamurthy ,  Jaime M. Guidry Auvil ,  Milton L. Brown

IPC: A61K31/498 ,  C07D241/42 ,  C07D213/30 ,  A61K31/343 ,  A61K31/44 ,  A61K31/473 ,  A61K45/06 ,  C07D215/14 ,  C07D307/77 ,  C07K16/18

CPC classification number: A61K31/498 ,  A61K31/343 ,  A61K31/44 ,  A61K31/473 ,  A61K45/06 ,  C07D213/30 ,  C07D215/14 ,  C07D241/42 ,  C07D307/77 ,  C07K16/18

Abstract: Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.

公开(公告)号：US09284368B2

公开(公告)日：2016-03-15

申请号：US14323374

申请日：2014-07-03

Applicant: Georgetown University

Inventor： Stephen W. Byers ,  Sivanesan Dakshanamurthy ,  Jaime M. Guidry Auvil ,  Milton L. Brown

IPC: C07D241/12 ,  C07K16/18 ,  C07D213/30 ,  C07D241/42 ,  A61K31/343 ,  A61K31/44 ,  A61K31/473 ,  A61K31/498 ,  A61K45/06 ,  C07D215/14 ,  C07D307/77

CPC classification number: A61K31/498 ,  A61K31/343 ,  A61K31/44 ,  A61K31/473 ,  A61K45/06 ,  C07D213/30 ,  C07D215/14 ,  C07D241/42 ,  C07D307/77 ,  C07K16/18

Abstract: This invention provides for a method of preventing or treating a cadherin-11 related disease in a subject, which includes administering to the subject an effective amount of a compound of the following formula: or a pharmaceutically acceptable salt or prodrug thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, X1 and X2 are as defined herein.

Abstract translation: 本发明提供了预防或治疗受试者中钙粘蛋白-11相关疾病的方法，其包括向受试者施用有效量的下式化合物或其药学上可接受的盐或前药，其中R1，R2 ，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11，R 12，X 1和X 2如本文所定义。

公开(公告)号：US20160151363A1

公开(公告)日：2016-06-02

申请号：US15017040

申请日：2016-02-05

Applicant: Georgetown University

Inventor： Stephen W. Byers ,  Sivanesan Dakshanamurthy ,  Jaime M. Guidry Auvil ,  Milton L. Brown

IPC: A61K31/498 ,  A61K45/06 ,  C07D241/42

CPC classification number: A61K31/498 ,  A61K31/343 ,  A61K31/44 ,  A61K31/473 ,  A61K45/06 ,  C07D213/30 ,  C07D215/14 ,  C07D241/42 ,  C07D307/77 ,  C07K16/18

Abstract: Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.

公开(公告)号：US20150064168A1

公开(公告)日：2015-03-05

申请号：US14323374

申请日：2014-07-03

Applicant: Georgetown University

Inventor： Stephen W. Byers ,  Sivanesan Dakshanamurthy ,  Jaime M. Guidry Auvil ,  Milton L. Brown

IPC: C07K16/18 ,  A61K31/498 ,  C07D213/30 ,  A61K45/06 ,  C07D307/77 ,  A61K31/343 ,  C07D215/14 ,  A61K31/473 ,  C07D241/42 ,  A61K31/44

CPC classification number: A61K31/498 ,  A61K31/343 ,  A61K31/44 ,  A61K31/473 ,  A61K45/06 ,  C07D213/30 ,  C07D215/14 ,  C07D241/42 ,  C07D307/77 ,  C07K16/18

Abstract: Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.

Abstract translation: 本发明描述了钙黏着蛋白-11抑制剂和预防和治疗钙粘蛋白-11相关疾病的方法。 钙粘蛋白-11相关疾病包括癌症和类风湿性关节炎。