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    Aminoalkyl-substituted 2-aminothiazoles and therapeutic agents containing them
    9.
    发明授权
    Aminoalkyl-substituted 2-aminothiazoles and therapeutic agents containing them 失效
    氨基取代的2-氨基丁酸和含有它们的治疗剂

    公开(公告)号：US5071864A

    公开(公告)日：1991-12-10

    申请号：US544900

    申请日：1990-06-28

    申请人： Beatrice Rendenbach-Mueller ,  Liliane Unger ,  Hans-Juergen Teschendorf

    发明人： Beatrice Rendenbach-Mueller ,  Liliane Unger ,  Hans-Juergen Teschendorf

    IPC分类号： C07D277/20 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/505 ,  A61P25/00 ,  A61P43/00 ,  C07D277/38 ,  C07D277/40 ,  C07D277/42 ,  C07D277/46 ,  C07D417/00 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

    CPC分类号： C07D417/06 ,  C07D277/40 ,  C07D277/42 ,  C07D417/12

    摘要： Aminoalkyl-substituted 2-aminothiazole derivatives of the general formula I ##STR1## where R.sup.1 and R.sup.2, which may be identical or different, are each hydrogen, C.sub.1 -C.sub.5 -alkyl, phenyl or C.sub.1 -C.sub.5 -alkanoyl, R.sup.3 is C.sub.1 -C.sub.5 -alkyl, phenyl which is unsubstituted or monosubstituted by halogen, C.sub.1 -C.sub.5 -alkyl or C.sub.1 -C.sub.5 -alkoxy, or thienyl,n is an integer of from 2 to 6, andNR.sup.4 R.sup.5 is one of the groups a, b, c or d ##STR2## where Ar is a phenyl ring which is unsubstituted or monosubstituted by C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -alkoxy, halogen, hydroxyl, nitro or trifluoromethyl, or is pyridyl, pyrimidinyl or thienyl, R.sup.5 is H or C.sub.1 -C.sub.5 -alkyl and R.sup.7 is phenyl which is unsubstituted or monosubstituted by C.sub.1 -C.sub.5 -alkyl, C.sub.1 -C.sub.5 -alkoxy, halogen, hydroxyl or trifluoromethyl, or R.sup.7 is thienyl, with the proviso that R.sup.3 is C.sub.1 -C.sub.5 alkyl only when either R.sup.1 and R.sup.2 are not both simultaneously H or when NR.sup.4 R.sup.5 is the group d, and their salts with physiologically tolerated acids, their preparation, their use for the preparation of a drug, and the drugs.

    摘要翻译： 通式I的氨基烷基取代的2-氨基噻唑衍生物其中R 1和R 2可以相同或不同，各自为氢，C 1 -C 5 - 烷基，苯基或C 1 -C 5 - 烷酰基，R 3为C1- C 5 - 烷基，未被卤素，C 1 -C 5 - 烷基或C 1 -C 5 - 烷氧基或噻吩基单取代的苯基，n为2至6的整数，并且NR 4 R 5为a，b，c之一 或者其中Ar是未被取代或被C 1 -C 5 - 烷基，C 1 -C 5 - 烷氧基，卤素，羟基，硝基或三氟甲基单取代的苯环，或者是吡啶基，嘧啶基或噻吩基，R 5是 H或C1-C5-烷基，R7是未被取代或被C1-C5-烷基，C1-C5-烷氧基，卤素，羟基或三氟甲基单取代的苯基，或R7是噻吩基，条件是R3仅为C1-C5烷基 当R 1和R 2不同时为H时，或当NR4R5为基团d时，及其与生理上耐受的酸的盐，其制备方法，其用于制备药物的用途， 和药物。