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6 条记录 (耗时 0.042 秒)

    Biochemical Synthesis of 6-Amino Caproic Acid
    5.
    发明申请
    Biochemical Synthesis of 6-Amino Caproic Acid 有权
    6-氨基己酸的生化合成

    公开(公告)号：US20070254341A1

    公开(公告)日：2007-11-01

    申请号：US10586132

    申请日：2005-01-17

    申请人： Petronella Raemakers-Franken ,  Petrus Nossin ,  Paul Brandts ,  Marcel Wubbolts ,  Wijnand Peeters ,  Sandra Ernste ,  Stefaan Wildeman De ,  Martin Schuermann

    发明人： Petronella Raemakers-Franken ,  Petrus Nossin ,  Paul Brandts ,  Marcel Wubbolts ,  Wijnand Peeters ,  Sandra Ernste ,  Stefaan Wildeman De ,  Martin Schuermann

    IPC分类号： C12P13/00 ,  C07C57/00 ,  C12P21/02

    CPC分类号： C12P13/005 ,  C07D223/10 ,  C12N9/001 ,  C12P13/02

    摘要： The invention relates to biochemical synthesis of 6-amino caproic acid from 6-aminohex-2-enoic acid compound or from 6-amino-2-hydroxyhexanoic acid, by treatment with an enzyme having α,β-enoate reductase activity towards molecules containing an α,β-enoate group and a primary amino group. The invention also relates to processes for obtaining suitable genetically engineered cells for being used in such biotransformation process, and to precursor fermentation of 6-amino caproic acid from intermediates leading to 6-amino caproic acid. Finally, the invention relates to certain novel biochemically produced compounds, namely 6-aminohex-2-enoic acid, 6-aminohexanoic acid, as well as to caprolactam produced therefrom and to nylon-6 and other derivatives produced from such biochemically produced compounds or caprolactam.

    摘要翻译： 本发明涉及6-氨基己-2-烯酸化合物或6-氨基-2-羟基己酸的6-氨基己酸的生物化学合成，该方法是用具有α，β-烯酸酯还原酶活性的酶对含有 α，β-戊酸酯基和伯氨基。 本发明还涉及用于获得在这种生物转化过程中使用的合适的遗传工程细胞的方法，以及从导致6-氨基己酸的中间体对6-氨基己酸的前体发酵。 最后，本发明涉及某些新的生物化学产生的化合物，即6-氨基己-2-烯酸，6-氨基己酸，以及由其制备的己内酰胺以及由这种生物化学产生的化合物或己内酰胺产生的尼龙-6和其它衍生物 。

    Process for the preparation of L-3, 4-dihydroxyphenylalanine by aerobic fermentation of a microorganism
    6.
    发明申请
    Process for the preparation of L-3, 4-dihydroxyphenylalanine by aerobic fermentation of a microorganism 审中-公开
    通过微生物的好氧发酵制备L-3,4-二羟基苯丙氨酸的方法

    公开(公告)号：US20060141587A1

    公开(公告)日：2006-06-29

    申请号：US10523370

    申请日：2003-07-31

    申请人： Marco Kramer ,  Susanne Kremer-Muschen ,  Marcel Wubbolts

    发明人： Marco Kramer ,  Susanne Kremer-Muschen ,  Marcel Wubbolts

    IPC分类号： C12P13/22 ,  C12N1/21

    CPC分类号： C12N9/0071 ,  C12P13/225

    摘要： The invention relates to a process for the preparation of L-3,4-dihydroxyphenylalanine wherein L-3,4,-dihydroxyphenylalanine is produced in a fermentation medium by aerobic fermentation of a recombinant microorganism having L-tyro-sine-3-hydroxy-mono-oxygenase activity and at least the metabolic pathways: glycolysis, pentose phosphate pathway, aromatic amino acid pathway, or derivative pathways thereof, which process comprises (i) a growth phase and a production phase, wherein L-3,4-dihydroxy-phenylalanine is produced in the fermentation medium, and 10 (ii) a downstream processing phase, and in which process L-3,4-dihydroxy phenylalanine is produced from a carbon source and the pH is in the range of from 1 to 7 during at least part of the production phase and/or downstream processing phase.

    摘要翻译： 本发明涉及一种制备L-3,4-二羟基苯丙氨酸的方法，其中在发酵培养基中，通过需氧发酵具有L-酪氨酸-3-羟基 - 单加氧酶活性和至少代谢途径：糖酵解，戊糖磷酸途径，芳香族氨基酸途径或其衍生途径，该方法包括（i）生长期和生产期，其中L-3,4-二羟基 - 在发酵培养基中产生苯丙氨酸，和10（ii）下游加工阶段，其中由碳源生产L-3,4-二羟基苯丙氨酸，并且在此期间pH在1至7的范围内 生产阶段和/或下游处理阶段的最少部分。