公开(公告)号：US4843086A

公开(公告)日：1989-06-27

申请号：US124197

申请日：1987-11-23

申请人： Gerhart Griss, deceased ,  Claus Schneider ,  Rudolf Hurnaus ,  Walter Kobinger ,  Ludwig Pichler ,  Rudolf Bauer ,  Joachim Mierau ,  Dieter Hinzen ,  Gunter Schingnitz

发明人： Gerhart Griss, deceased ,  Claus Schneider ,  Rudolf Hurnaus ,  Walter Kobinger ,  Ludwig Pichler ,  Rudolf Bauer ,  Joachim Mierau ,  Dieter Hinzen ,  Gunter Schingnitz

IPC分类号： A61K31/425 ,  C07D277/82

CPC分类号： C07D277/82

摘要： This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nuclei may each be substituted by 1 or 2 halogen atoms.R.sub.2 represents a hydrogen atom or an alkyl group,R.sub.3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by fluorine, chlorine or bromine atoms,R.sub.4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, orR.sub.3 and R.sub.4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof.The compounds of general formula I above in which one of the groups R.sub.1 or R.sub.3 or both groups R.sub.1 and R.sub.3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.

摘要翻译： 本发明涉及通式为（I）的新的四氢苯并噻唑，其中R 1表示氢原子，烷基，烯基或炔基，烷酰基，苯基烷基或苯基烷酰基，而上述苯基核 可各自被1或2个卤素原子取代。 R2表示氢原子或烷基，R3表示氢原子，烷基，环烷基，烯基或炔基，烷酰基，苯基烷基或苯基烷酰基，而苯基核可以被氟取代 ，氯或溴原子，R4表示氢原子，烷基，烷基或烯基或R3和R4以及它们之间的氮原子表示吡咯烷子基，哌啶子基，六亚甲基亚氨基或吗啉代基，对映体和酸加成 的盐。 上述通式I的化合物，其中R1或R3基团或R1和R3两个基团之一表示酰基，是制备其它具有有价值的药理学性质的通式I化合物的有价值的中间产物。 新化合物可以使用本身已知的方法制备。

公开(公告)号：US4886812A

公开(公告)日：1989-12-12

申请号：US256671

申请日：1988-10-12

申请人： Gerhart Griss, deceased ,  Claus Schneider ,  Rudolf Hurnaus ,  Walter Kobinger ,  Ludwig Pichler ,  Rudolf Bauer ,  Joachim Mierau ,  Dieter Hinzen ,  Gunter Schingnitz

发明人： Gerhart Griss, deceased ,  Claus Schneider ,  Rudolf Hurnaus ,  Walter Kobinger ,  Ludwig Pichler ,  Rudolf Bauer ,  Joachim Mierau ,  Dieter Hinzen ,  Gunter Schingnitz

IPC分类号： A61K31/425 ,  C07D277/82

CPC分类号： C07D277/82

摘要： This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nucleic may each be substituted by 1 or 2 halogen atoms,R.sub.2 represents a hydrogen atom or an alkyl group,R.sub.3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by fluorine, chlorine or bromine atoms,R.sub.4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, orR.sub.3 and R.sub.4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof.The compounds of general formula I above in which one of the groups R.sub.1 or R.sub.3 or both groups R.sub.1 and R.sub.3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.

摘要翻译： 本发明涉及通式为（I）的新的四氢苯并噻唑，其中R 1表示氢原子，烷基，烯基或炔基，烷酰基，苯基烷基或苯基烷酰基，而上述苯基核酸 可各自被1或2个卤素原子取代，R2表示氢原子或烷基，R3表示氢原子，烷基，环烷基，烯基或炔基，烷酰基，苯基烷基或苯基烷酰基 基团可以被氟，氯或溴原子取代，R4表示氢原子，烷基，烷基或烯基，或者R3和R4与它们之间的氮原子一起代表吡咯烷子基，哌啶子基， 六亚甲基亚氨基或吗啉代基，其对映异构体及其酸加成盐。 上述通式I的化合物，其中R1或R3基团或R1和R3两个基团之一表示酰基，是制备其它具有有价值的药理学性质的通式I化合物的有价值的中间产物。 新化合物可以使用本身已知的方法制备。

公开(公告)号：US4731374A

公开(公告)日：1988-03-15

申请号：US810947

申请日：1985-12-19

申请人： Gerhart Griss, deceased ,  Rudolf Hurnaus ,  Walter Kobinger ,  Ludwig Pichler ,  Rudolf Bauer ,  Joachim Mierau ,  Dieter Hinzen ,  Gunter Schingnitz

发明人： Gerhart Griss, deceased ,  Rudolf Hurnaus ,  Walter Kobinger ,  Ludwig Pichler ,  Rudolf Bauer ,  Joachim Mierau ,  Dieter Hinzen ,  Gunter Schingnitz

IPC分类号： A61K31/425 ,  C07D277/82

CPC分类号： C07D277/82

摘要： This invention relates to new tetrahydrobenzthiazoles of general formula ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkenyl or alkynylk group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the above mentioned phenyl nuclei may each be substituted by 1 or 2 halogen atoms,R.sub.2 represents a hydrogen atom or an alkyl group,R.sub.3 represents a hydrogen atom, an alkyl group a cycloalkyl group, an alkenyl or alkynyl group, an alkanoyl group, a phenyl alkyl or phenyl alkanoyl group, while the phenyl nucleus may be substituted by flurorine, chlorine or bromine atoms,R.sub.4 represents a hydrogen atom, an alkyl group, an alkyl or alkenyl group, orR.sub.3 and R.sub.4 together with the nitrogen atom between them represent a pyrrolidino, piperidino, hexamethyleneimino or morpholino group, the enantiomers and the acid addition salts thereof.The compounds of general formula I above in which one of the groups R.sub.1 or R.sub.3 or both groups R.sub.1 and R.sub.3 represent an acyl group are valuable intermediate products for preparing the other compounds of general formula I which have valuable pharmacological properties. The new compounds may be prepared using methods known per se.

摘要翻译： 本发明涉及通式为（I）的新的四氢苯并噻唑，其中R 1表示氢原子，烷基，烯基或炔基，烷酰基，苯基烷基或苯基烷酰基，而上述苯基核 可各自被1或2个卤素原子取代，R2表示氢原子或烷基，R3表示氢原子，烷基，环烷基，烯基或炔基，烷酰基，苯基烷基或苯基烷酰基 基团可以被氟里酰，氯或溴原子取代，R4表示氢原子，烷基，烷基或烯基，或者R3和R4与它们之间的氮原子一起代表吡咯烷子基，哌啶子基， 六亚甲基亚氨基或吗啉代基，其对映异构体及其酸加成盐。 上述通式I的化合物，其中R1或R3基团或R1和R3两个基团之一表示酰基，是制备其它具有有价值的药理学性质的通式I化合物的有价值的中间产物。 新化合物可以使用本身已知的方法制备。

公开(公告)号：US4981862A

公开(公告)日：1991-01-01

申请号：US287829

申请日：1988-12-20

申请人： Claus Schneider ,  Herbert Merz ,  Rainer Sobotta ,  Rudolf Bauer ,  Joachim Mierau ,  Gunter Schingnitz

发明人： Claus Schneider ,  Herbert Merz ,  Rainer Sobotta ,  Rudolf Bauer ,  Joachim Mierau ,  Gunter Schingnitz

IPC分类号： C07D277/60 ,  A61K31/425 ,  A61K31/428 ,  A61P5/00 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  C07D277/82

CPC分类号： C07D277/82

摘要： Tetrahydrobenzothiazole derivatives of the formula ##STR1## wherein n is 1, 2 or 3 and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are defined substituents, said derivatives (I) being suitable as active compounds for treating parkinsonism or Parkinson's Disease.

摘要翻译： 式（Ⅰ）的四氢苯并噻唑衍生物其中n为1,2或3，R 1，R 2，R 3，R 4，R 5和R 6为定义的取代基，所述衍生物（I）适用作治疗帕金森综合征或帕金森病 疾病。

公开(公告)号：US5006533A

公开(公告)日：1991-04-09

申请号：US440917

申请日：1989-11-22

申请人： Rainer Sobotta ,  Adolf Langbein ,  Herbert Merz ,  Rudolf Bauer ,  Joachim Mierau

发明人： Rainer Sobotta ,  Adolf Langbein ,  Herbert Merz ,  Rudolf Bauer ,  Joachim Mierau

IPC分类号： C07D221/22 ,  A61K31/435 ,  A61P25/00 ,  A61P25/02 ,  A61P25/20 ,  C07D451/04 ,  C07D471/02

CPC分类号： C07D451/04

摘要： 3-Bromo-2,6-dimethoxybenzamides useful as neuroleptic agents are described.

摘要翻译： 描述了用作神经安定药的3-溴-2,6-二甲氧基苯甲酰胺。

公开(公告)号：US4393069A

公开(公告)日：1983-07-12

申请号：US324680

申请日：1981-11-25

申请人： Adolf Langbein ,  Herbert Merz ,  Rainer Sobotta ,  Rudolf Bauer ,  Hans M. Jennewein ,  Joachim Mierau

发明人： Adolf Langbein ,  Herbert Merz ,  Rainer Sobotta ,  Rudolf Bauer ,  Hans M. Jennewein ,  Joachim Mierau

IPC分类号： A61K31/46 ,  A61K31/49 ,  A61P5/00 ,  C07D451/06 ,  C07D401/02

CPC分类号： C07D451/06

摘要： Compounds of the formula ##STR1## wherein Ar is ##STR2## R.sub.1 is hydrogen, fluorine, bromine, methyl or methoxy; X is .dbd.CO, .dbd.CH--CN, .dbd.CH--OH, --O--, --S--, --NH--, ##STR3## and R is hydrogen, 4-fluoro, 4-chloro, 4-trifluoromethyl, 3-trifluoromethyl, 3-trifluoromethyl-4-chloro, 4-methyl or 4-methoxy;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as neuroleptics.

摘要翻译： 其中Ar为R 1的式“IMAGE”的化合物是氢，氟，溴，甲基或甲氧基; X为= CO，= CH-CN，= CH-OH，-O - ， - S - ， - NH-，+ IMA，其中R为氢，4-氟，4-氯， 三氟甲基，3-三氟甲基，3-三氟甲基-4-氯，4-甲基或4-甲氧基; 和无毒的，药学上可接受的酸加成盐。 化合物及其盐可用作神经安定药。

公开(公告)号：US5894662A

公开(公告)日：1999-04-20

申请号：US665559

申请日：1996-06-18

申请人： Rudolf Bauer ,  Horst Doppling

发明人： Rudolf Bauer ,  Horst Doppling

IPC分类号： B21K1/00 ,  B21K1/44 ,  B23D15/00 ,  B23D35/00 ,  B23P15/00 ,  F01L1/18

CPC分类号： B21K1/205 ,  B21K1/44 ,  B23D15/00 ,  B23D35/001 ,  B23P15/00 ,  F01L1/18 ,  Y10T29/49229 ,  Y10T29/49295

摘要： A method for making a trunnion for a rocker arm or a finger lever of an internal combustion engine from a piece of rod-shaped ground stock by removal of a peripheral section to produce a flat bearing surface including forming the round stock into a barrel-shaped blank by upsetting, shaping the barrel-shaped blank into a rotationally symmetrical element including a central shoulder having a uniform diameter which is greater than the diameter of the trunnion and removing the peripheral section at any point from the central shoulder by shearing from two sides thereof in an axial direction of the rotationally symmetrical element whereby any cutting plane material from the central shoulder is directed towards a sheared surface whereby the bearing surface is a hardened surface.

摘要翻译： 一种用于通过移除周边部分从一块棒状地面料制作用于内燃机的摇臂或指杆的耳轴以产生平坦的支承表面的方法，包括将圆形坯料形成为桶状 通过镦锻将筒形坯料成形为旋转对称的元件，其包括具有大于耳轴直径的均匀直径的中心肩部，并且通过从其两侧剪切而从中心肩部的任何位置移除周边部分 在旋转对称的元件的轴向方向上，从中央肩部的任何切割平面材料被引向剪切表面，由此支承表面是硬化表面。

公开(公告)号：US5657225A

公开(公告)日：1997-08-12

申请号：US426692

申请日：1995-04-21

申请人： Rudolf Bauer

发明人： Rudolf Bauer

IPC分类号： G05D1/02 ,  G06G7/76

CPC分类号： G05D1/027 ,  G05D2201/0211

摘要： The method provides a better incorporation of a defined safety interval from obstacles in the route planning of a self-propelled mobile unit. By contrast to methods that were hitherto standard, a shell with equidistant spacing from a housing of the self-propelled mobile unit is not placed around the mobile unit; rather, the safety interval is calculated via the route at a drive wheel of the self-propelled mobile unit. That is, the kinematics of the self-propelled mobile unit are first used in the calculation of the safety interval from obstacles. The advantage is that better maneuverability is achieved between obstacles located close to one another.

摘要翻译： 该方法提供了在自行式移动单元的路线规划中更好地纳入从障碍物确定的安全间隔。 与迄今为止标准的方法相反，与自推进移动单元的壳体具有等距离间隔的壳体不会放置在移动单元周围; 而是通过在自行式移动单元的驱动轮上的路线来计算安全间隔。 也就是说，自推进移动单元的运动学首先用于计算障碍物的安全间隔。 优点是在彼此靠近的障碍物之间实现更好的机动性。

公开(公告)号：US5610163A

公开(公告)日：1997-03-11

申请号：US405111

申请日：1995-03-16

申请人： Rolf Banholzer ,  Rudolf Bauer ,  Richard Reichl

发明人： Rolf Banholzer ,  Rudolf Bauer ,  Richard Reichl

IPC分类号： C07D451/10 ,  C07D451/14 ,  A61K31/435 ,  C07D401/00 ,  C07D451/12

CPC分类号： C07D451/14 ,  C07D451/10

摘要： Compounds of the formula ##STR1## of which, in exemplary compounds, the thienyl group is attached via the 2-position and:(a) A is 3.alpha.-(6.beta., 7.beta.-epoxy)-tropanyl methobromide and R.sub.1 is 2-thienyl;(b) A is 3.alpha.-(6, 7dehydro)-tropanyl methobromide and R.sub.1 is 2-thienyl;(c) A is 3.beta.-tropanyl methobromide and R.sub.1 is 2-thienyl; and,(d) A is 3.alpha.-(N-isopropyl)-nortropanyl methobromide and R.sub.1 is cyclopentyl.These are anticholinergics. Administered by inhalation, they are useful for the treatment of chronic obstructive bronchitis or slight to moderately severe asthma. Administered by the intravenous or oral routes, they are useful for the treatment of vagally induced sinus bradycardia.

摘要翻译： 其中在示例性化合物中噻吩基通过2-位连接的式（IMA）的化合物：（a）A是3α-（6β，7β-环氧） - 丙酰基甲溴化物，R 1是2 噻吩基 （b）A是3α-（6,7-脱氢） - 丙酰基甲溴化物，R 1是2-噻吩基; （c）A是3β-丙酰基甲溴化物，R 1是2-噻吩基; 和（d）A是3α-（N-异丙基） - 异丙基甲基溴化氢，R1是环戊基。 这些都是抗胆碱药物。 通过吸入给药，可用于治疗慢性阻塞性支气管炎或轻度至中度重度哮喘。 通过静脉或口服途径给药，可用于治疗迷走神经性窦性心动过缓。

公开(公告)号：US07740639B2

公开(公告)日：2010-06-22

申请号：US10565735

申请日：2004-07-13

申请人： Christian Hummel ,  Gerhard Emberger ,  Rudolf Bauer

发明人： Christian Hummel ,  Gerhard Emberger ,  Rudolf Bauer

IPC分类号： A61B17/10

CPC分类号： A61B17/122 ,  A61B17/1227 ,  A61B17/1285 ,  A61B2017/12004

摘要： A method and apparatus for the endoscopic application of self-closing medical clips (3), in particular, for arresting internal bleeding. The distal end of a catheter tube (1) is introduced into the body of a living being to be treated. Several clips (3), arranged successively in the catheter tube (1), are pushed forward in the direction of the tube distal end by a user device located at the proximal end of the catheter tube (1). The foremost clip (3) to be applied is pushed out of the distal end and opened by an actuation device. The actuation device includes an actuation element (21) which can be actuated by the user device, moved longitudinally into the catheter tube (1), and acts on the first front clip (3), as well as a control part (25) which converts the actuation force of the actuation element into an opening movement of the legs (5) of the clip (3). After the opening of the clip (3), the actuation element (21) is separated from the clip (3), for releasing the clip to close its legs (5) for application, and to functionally link with the following clip (3) in the catheter tube (1).

摘要翻译： 一种用于内窥镜应用自闭合医疗夹（3）的方法和装置，特别是用于阻止内部出血。 将导管（1）的远端引入待治疗的生物体内。 导管（1）中连续布置的几个夹子（3）通过位于导管（1）的近端处的使用者装置沿管远端的方向向前推动。 要施加的最重要的夹子（3）被推出远端并由致动装置打开。 所述致动装置包括致动元件（21），其可由使用者装置致动，纵向移动到导管管（1）中，并作用在第一前夹子（3）上，以及控制部件（25） 将致动元件的致动力转换成夹子（3）的腿部（5）的打开运动。 在夹子（3）打开之后，致动元件（21）与夹子（3）分离，用于释放夹子以关闭其腿部（5）以供施用，并且与下一个夹子（3）功能性地连接， 在导管（1）中。