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公开(公告)号：US20230124998A1
公开(公告)日：2023-04-20
申请号：US17872042
申请日：2022-07-25
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C40B40/08 , C12N15/10 , C12Q1/6888 , C07K16/00 , C07K14/725 , C07K14/74 , C12Q1/6869 , C40B50/06 , C12Q1/6806
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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公开(公告)号：US11427933B2
公开(公告)日：2022-08-30
申请号：US17392892
申请日：2021-08-03
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C40B50/06 , C40B40/08 , C12N15/10 , C12Q1/6888 , C07K16/00 , C07K14/725 , C07K14/74 , C12Q1/6869 , C12Q1/6806
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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公开(公告)号：US20220243197A1
公开(公告)日：2022-08-04
申请号：US17607497
申请日：2020-04-30
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Rena Aviva Mizrahi , Yoong Wearn Lim , Michael Asensio , Sheila Keating , Renee Leong , Jackson Leong
Abstract: Provided herein are compositions comprising recombinant polyclonal proteins (RPPs) derived from mammalian plasma cells and plasmablasts. Also provided are methods of using the RPPs.
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公开(公告)号：US12195880B2
公开(公告)日：2025-01-14
申请号：US17872042
申请日：2022-07-25
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C40B50/06 , C07K14/725 , C07K14/74 , C07K16/00 , C12N15/10 , C12Q1/6806 , C12Q1/6869 , C12Q1/6888 , C40B40/08
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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公开(公告)号：US11685779B2
公开(公告)日：2023-06-27
申请号：US17386504
申请日：2021-07-27
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Sheila Keating , Adam Shultz Adler , Michael Asensio , Kacy Stadtmiller , Emily Benzie , Ariel Niedecken , Angelica V. Medina-Cucurella , Rena Aviva Mizrahi , Yoong Wearn Lim
CPC classification number: C07K16/2803 , A61P31/14 , C40B40/10 , A61K2039/505 , C07K2317/565 , C07K2317/92
Abstract: Provided herein are compositions comprising recombinant polyclonal proteins (RPPs) derived from mammalian plasma cells and plasmablasts. Also provided are methods of using the RPPs.
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Patent Agency Ranking
公开(公告)号：US10329557B2
公开(公告)日：2019-06-25
申请号：US15920092
申请日：2018-03-13
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C40B50/06 , C12N15/10 , C12Q1/6888 , C07K16/00 , C07K14/725 , C07K14/74 , C12Q1/6869 , C12Q1/6806
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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公开(公告)号：US20220064303A1
公开(公告)日：2022-03-03
申请号：US17418776
申请日：2019-12-27
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Rena Aviva Mizrahi , Yoong Wearn Lim , Michael Asensio , Erica Lyn Stone
Abstract: Provided herein are antigen-binding proteins (ABPs) that selectively bind to CTLA-4 and its isoforms and homologs, and compositions comprising the ABPs. Also provided are methods of using the ABPs, such as therapeutic and diagnostic methods.
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公开(公告)号：US20210371851A1
公开(公告)日：2021-12-02
申请号：US17392892
申请日：2021-08-03
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C12N15/10 , C12Q1/6888 , C07K16/00 , C07K14/725 , C07K14/74 , C12Q1/6869 , C12Q1/6806
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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公开(公告)号：US11111490B2
公开(公告)日：2021-09-07
申请号：US16443381
申请日：2019-06-17
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C40B40/08 , C12N15/10 , C12Q1/6888 , C07K16/00 , C07K14/725 , C07K14/74 , C12Q1/6869 , C12Q1/6806 , C40B50/06
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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公开(公告)号：US20230287112A1
公开(公告)日：2023-09-14
申请号：US18295645
申请日：2023-04-04
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Sheila Keating , Adam Shultz Adler , Michael Asensio , Kacy Stadtmiller , Emily Benzie , Ariel Niedecken , Angelica V. Medina-Cucurella , Rena Aviva Mizrahi , Yoong Wearn Lim
CPC classification number: C07K16/2803 , A61P31/14 , C40B40/10 , A61K2039/505
Abstract: Provided herein are compositions comprising recombinant polyclonal proteins (RPPs) derived from mammalian plasma cells and plasmablasts. Also provided are methods of using the RPPs.
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