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公开(公告)号：US20230287112A1
公开(公告)日：2023-09-14
申请号：US18295645
申请日：2023-04-04
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Sheila Keating , Adam Shultz Adler , Michael Asensio , Kacy Stadtmiller , Emily Benzie , Ariel Niedecken , Angelica V. Medina-Cucurella , Rena Aviva Mizrahi , Yoong Wearn Lim
CPC classification number: C07K16/2803 , A61P31/14 , C40B40/10 , A61K2039/505
Abstract: Provided herein are compositions comprising recombinant polyclonal proteins (RPPs) derived from mammalian plasma cells and plasmablasts. Also provided are methods of using the RPPs.
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公开(公告)号：US11441240B2
公开(公告)日：2022-09-13
申请号：US16414548
申请日：2019-05-16
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C40B40/08 , C12N15/10 , C12Q1/6888 , C07K16/00 , C07K14/725 , C07K14/74 , C12Q1/6869 , C40B50/06 , C12Q1/6806
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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公开(公告)号：US20220064268A1
公开(公告)日：2022-03-03
申请号：US17469493
申请日：2021-09-08
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Sheila Keating , Adam Shultz Adler , Michael Asensio , Kacy Stadtmiller , Emily Benzie , Ariel Niedecken , Angelica V. Medina-Cucurella , Rena Aviva Mizrahi , Yoong Wearn Lim
Abstract: Provided herein are compositions comprising recombinant polyclonal protein (RPP) derived from mammalian plasma cells and plasmablasts. Specifically, RPPs specific to Zika virus are provided. Also provided are the methods of using the RPP for treatment of viral infection and the methods of making the RPPs.
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公开(公告)号：US10689641B2
公开(公告)日：2020-06-23
申请号：US16399759
申请日：2019-04-30
Applicant: Gigagen, Inc.
Inventor： David Scott Johnson , Adam Adler , Rena Mizrahi
IPC: C40B40/08 , C12N15/10 , C07K16/00 , C07K14/725 , C12Q1/6876 , C40B50/06
Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
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公开(公告)号：US20190316118A1
公开(公告)日：2019-10-17
申请号：US16443381
申请日：2019-06-17
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C12N15/10 , C12Q1/6869 , C07K14/74 , C07K14/725 , C12Q1/6806 , C12Q1/6888 , C07K16/00
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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Patent Agency Ranking
公开(公告)号：US20190002974A1
公开(公告)日：2019-01-03
申请号：US16132211
申请日：2018-09-14
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Everett Hurteau Meyer
IPC: C12Q1/6874 , C12Q1/6844 , C12N15/10 , C12Q1/6888 , C12Q1/6886 , C12Q1/6883 , C07K16/00 , C12Q1/6837 , C40B50/06
CPC classification number: C12Q1/6874 , C07K16/00 , C07K2317/622 , C12N15/1006 , C12N15/1065 , C12N15/1075 , C12Q1/6837 , C12Q1/6846 , C12Q1/6883 , C12Q1/6886 , C12Q1/6888 , C12Q2600/156 , C40B50/06 , C12Q2525/161 , C12Q2525/307 , C12Q2563/159
Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.
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公开(公告)号：US20180258422A1
公开(公告)日：2018-09-13
申请号：US15920092
申请日：2018-03-13
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Shultz Adler , Matthew James Spindler , Rena Aviva Mizrahi
IPC: C12N15/10 , C12Q1/6888 , C12Q1/6869 , C07K14/725 , C07K14/74 , C07K16/00
CPC classification number: C12N15/1065 , C07K14/7051 , C07K14/70539 , C07K16/005 , C12N15/1075 , C12Q1/6806 , C12Q1/6869 , C12Q1/6888 , C40B50/06 , C12Q2525/161 , C12Q2535/122 , C12Q2563/159 , C12Q2565/629
Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.
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公开(公告)号：US09926554B2
公开(公告)日：2018-03-27
申请号：US15598313
申请日：2017-05-18
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Adam Adler , Rena Mizrahi
CPC classification number: C12N15/1037 , C07K14/7051 , C07K16/00 , C07K2317/14 , C07K2317/622 , C12N15/1075 , C12N15/1093 , C12Q1/6876 , C40B50/06
Abstract: Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
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公开(公告)号：US09695474B2
公开(公告)日：2017-07-04
申请号：US15159674
申请日：2016-05-19
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Everett Hurteau Meyer
CPC classification number: C12Q1/6874 , C07K16/00 , C07K2317/622 , C12N15/1006 , C12N15/1065 , C12N15/1075 , C12Q1/6837 , C12Q1/6846 , C12Q1/6883 , C12Q1/6886 , C12Q1/6888 , C12Q2600/156 , C40B50/06 , C12Q2525/161 , C12Q2525/307 , C12Q2563/159
Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.
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公开(公告)号：US20170166889A1
公开(公告)日：2017-06-15
申请号：US15431660
申请日：2017-02-13
Applicant: GigaGen, Inc.
Inventor： David Scott Johnson , Everett Hurteau Meyer
CPC classification number: C12Q1/6874 , C07K16/00 , C07K2317/622 , C12N15/1006 , C12N15/1065 , C12N15/1075 , C12Q1/6837 , C12Q1/6846 , C12Q1/6883 , C12Q1/6886 , C12Q1/6888 , C12Q2600/156 , C40B50/06 , C12Q2525/161 , C12Q2525/307 , C12Q2563/159
Abstract: Methods and systems are provided for massively parallel genetic analysis of single cells in emulsion droplets or reaction containers. Genetic loci of interest are targeted in a single cell using a set of probes, and a fusion complex is formed by molecular linkage and amplification techniques. Methods are provided for high-throughput, massively parallel analysis of the fusion complex in a single cell in a population of at least 10,000 cells. Also provided are methods for tracing genetic information back to a cell using barcode sequences.
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