公开(公告)号：US20210371851A1

公开(公告)日：2021-12-02

申请号：US17392892

申请日：2021-08-03

Applicant: GigaGen, Inc.

Inventor： David Scott Johnson ,  Adam Shultz Adler ,  Matthew James Spindler ,  Rena Aviva Mizrahi

IPC: C12N15/10 ,  C12Q1/6888 ,  C07K16/00 ,  C07K14/725 ,  C07K14/74 ,  C12Q1/6869 ,  C12Q1/6806

Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.

公开(公告)号：US11111490B2

公开(公告)日：2021-09-07

申请号：US16443381

申请日：2019-06-17

Applicant: GigaGen, Inc.

Inventor： David Scott Johnson ,  Adam Shultz Adler ,  Matthew James Spindler ,  Rena Aviva Mizrahi

IPC: C40B40/08 ,  C12N15/10 ,  C12Q1/6888 ,  C07K16/00 ,  C07K14/725 ,  C07K14/74 ,  C12Q1/6869 ,  C12Q1/6806 ,  C40B50/06

Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.

公开(公告)号：US20230124998A1

公开(公告)日：2023-04-20

申请号：US17872042

申请日：2022-07-25

Applicant: GigaGen, Inc.

Inventor： David Scott Johnson ,  Adam Shultz Adler ,  Matthew James Spindler ,  Rena Aviva Mizrahi

IPC: C40B40/08 ,  C12N15/10 ,  C12Q1/6888 ,  C07K16/00 ,  C07K14/725 ,  C07K14/74 ,  C12Q1/6869 ,  C40B50/06 ,  C12Q1/6806

Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.

公开(公告)号：US11427933B2

公开(公告)日：2022-08-30

申请号：US17392892

申请日：2021-08-03

Applicant: GigaGen, Inc.

Inventor： David Scott Johnson ,  Adam Shultz Adler ,  Matthew James Spindler ,  Rena Aviva Mizrahi

IPC: C40B50/06 ,  C40B40/08 ,  C12N15/10 ,  C12Q1/6888 ,  C07K16/00 ,  C07K14/725 ,  C07K14/74 ,  C12Q1/6869 ,  C12Q1/6806

Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.

公开(公告)号：US12195880B2

公开(公告)日：2025-01-14

申请号：US17872042

申请日：2022-07-25

Applicant: GigaGen, Inc.

Inventor： David Scott Johnson ,  Adam Shultz Adler ,  Matthew James Spindler ,  Rena Aviva Mizrahi

IPC: C40B50/06 ,  C07K14/725 ,  C07K14/74 ,  C07K16/00 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6888 ,  C40B40/08

Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.

公开(公告)号：US10329557B2

公开(公告)日：2019-06-25

申请号：US15920092

申请日：2018-03-13

Applicant: GigaGen, Inc.

Inventor： David Scott Johnson ,  Adam Shultz Adler ,  Matthew James Spindler ,  Rena Aviva Mizrahi

IPC: C40B50/06 ,  C12N15/10 ,  C12Q1/6888 ,  C07K16/00 ,  C07K14/725 ,  C07K14/74 ,  C12Q1/6869 ,  C12Q1/6806

Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.

公开(公告)号：US11441240B2

公开(公告)日：2022-09-13

申请号：US16414548

申请日：2019-05-16

Applicant: GigaGen, Inc.

Inventor： David Scott Johnson ,  Adam Shultz Adler ,  Matthew James Spindler ,  Rena Aviva Mizrahi

IPC: C40B40/08 ,  C12N15/10 ,  C12Q1/6888 ,  C07K16/00 ,  C07K14/725 ,  C07K14/74 ,  C12Q1/6869 ,  C40B50/06 ,  C12Q1/6806

Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.

公开(公告)号：US20190316118A1

公开(公告)日：2019-10-17

申请号：US16443381

申请日：2019-06-17

Applicant: GigaGen, Inc.

Inventor： David Scott Johnson ,  Adam Shultz Adler ,  Matthew James Spindler ,  Rena Aviva Mizrahi

IPC: C12N15/10 ,  C12Q1/6869 ,  C07K14/74 ,  C07K14/725 ,  C12Q1/6806 ,  C12Q1/6888 ,  C07K16/00

Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.

公开(公告)号：US20180258422A1

公开(公告)日：2018-09-13

申请号：US15920092

申请日：2018-03-13

Applicant: GigaGen, Inc.

Inventor： David Scott Johnson ,  Adam Shultz Adler ,  Matthew James Spindler ,  Rena Aviva Mizrahi

IPC: C12N15/10 ,  C12Q1/6888 ,  C12Q1/6869 ,  C07K14/725 ,  C07K14/74 ,  C07K16/00

CPC classification number: C12N15/1065 ,  C07K14/7051 ,  C07K14/70539 ,  C07K16/005 ,  C12N15/1075 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6888 ,  C40B50/06 ,  C12Q2525/161 ,  C12Q2535/122 ,  C12Q2563/159 ,  C12Q2565/629

Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.

公开(公告)号：US20190390190A1

公开(公告)日：2019-12-26

申请号：US16414548

申请日：2019-05-16

Applicant: GigaGen, Inc.

Inventor： David Scott Johnson ,  Adam Shultz Adler ,  Matthew James Spindler ,  Rena Aviva Mizrahi

IPC: C12N15/10 ,  C12Q1/6806 ,  C12Q1/6869 ,  C07K14/74 ,  C07K14/725 ,  C07K16/00 ,  C12Q1/6888

Abstract: Provided herein are methods that enable parallel evaluation of multiple functional nucleic acids in individual cells or subpopulations of cells, in the context of incubation with other types of single cells. The key insight is concurrent measurement of polynucleic acids derived from small populations of at least two different cell types, such that function in one cell type is linked to the clonal identity of another cell. These methods simultaneously process thousands, millions, or more single cells or small populations of cells. The method integrates molecular, algorithmic, and engineering approaches. This invention has broad and useful application in a number of biological and medical fields, including immunology and drug discovery.