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    Pyrimidin-4-one compounds
    3.
    发明授权
    Pyrimidin-4-one compounds 失效
    嘧啶-4-酮化合物

    公开(公告)号：US06747032B2

    公开(公告)日：2004-06-08

    申请号：US10125188

    申请日：2002-04-18

    申请人： Gilbert Lavielle ,  Thierry Dubuffet ,  Olivier Muller ,  Mark Millan ,  Anne Dekeyne ,  Mauricette Brocco

    发明人： Gilbert Lavielle ,  Thierry Dubuffet ,  Olivier Muller ,  Mark Millan ,  Anne Dekeyne ,  Mauricette Brocco

    IPC分类号： C07D51900

    CPC分类号： C07D471/04

    摘要： Compound of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen atom, a halogen atom or a group selected from alkyl, alkoxy, polyhaloalkyl, hydroxy, cyano, nitro and amino,  or R1 with R2, R2 with R3, or R3 with R4, together with the carbon atoms carrying them, form an optionally substituted benzene ring or an optionally substituted heteroaromatic ring, X represents an oxygen atom or a methylene group, A represents an alkylene chain,  represents an optionally substituted, unsaturated, nitrogen-containing heterocycle and R5 represents an alkyl group, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid, a medicinal products containing the same are useful as a double &agr;2/5-HT2c antagonist.

    摘要翻译： 式（I）化合物：其中：R 1，R 2，R 3和R 4可以相同或不同，表示氢原子，卤素原子或选自烷基，烷氧基，多卤代烷基，羟基，氰基，硝基 和氨基，或R 1与R 2，R 2与R 3或R 3与R 4一起形成任选取代的苯环或任选取代的杂芳环，X表示氧原子或亚甲基，A表示 亚烷基链表示任选取代的不饱和的含氮杂环，R5表示烷基，其对映异构体和非对映异构体及其与药学上可接受的酸的加成盐，含有该酸的药物可用作双重α2/ 5 -HT2c拮抗剂。

    Indoline compounds
    5.
    发明授权
    Indoline compounds 失效
    二氢吲哚化合物

    公开(公告)号：US07053108B2

    公开(公告)日：2006-05-30

    申请号：US10813347

    申请日：2004-03-30

    申请人： Gilbert Lavielle ,  Olivier Muller ,  Mark Millan ,  Alain Gobert

    发明人： Gilbert Lavielle ,  Olivier Muller ,  Mark Millan ,  Alain Gobert

    IPC分类号： A61K31/443 ,  C07D401/12

    CPC分类号： C07D401/12

    摘要： A compound of formula (I): wherein: R1 and R2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, and R3 represents hydrogen,orR1 represents hydrogen, and R2 and R3 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl,its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicaments.

    摘要翻译： 式（I）化合物：其中：R 1和R 2一起形成任选被卤素取代的苯并环，或烷基，烷氧基，氰基，硝基，羟基， 氨基，烷基氨基，二烷基氨基或三氟甲基，R 3表示氢，或R 1表示氢，R 2和R 3 硝基，羟基，氨基，烷基氨基，二烷基氨基或三氟甲基，其对映异构体，非对映异构体及其与药学上可接受的酸或碱的加成盐共同形成任选被卤素取代的苯并环， 和药物。

    Benzoindoline compounds
    7.
    发明申请
    Benzoindoline compounds 失效
    苯并二氢吲哚化合物

    公开(公告)号：US20050059675A1

    公开(公告)日：2005-03-17

    申请号：US10925712

    申请日：2004-08-25

    申请人： Gilbert Lavielle ,  Olivier Muller ,  Mark Millan ,  Alain Gobert ,  Benjamin Di Cara

    发明人： Gilbert Lavielle ,  Olivier Muller ,  Mark Millan ,  Alain Gobert ,  Benjamin Di Cara

    IPC分类号： A61K31/496 ,  A61P15/00 ,  A61P15/10 ,  A61P25/00 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D209/60 ,  C07D401/12 ,  C07D403/12 ,  C07D43/02

    CPC分类号： C07D209/60

    摘要： A compound of formula (I): wherein: R1 and R2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, and R3 and R4 represent hydrogen, or R1 and R4 represent hydrogen and R2 and R3 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, or R1 and R2 represent hydrogen and R3 and R4 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, addition salts thereof with a pharmaceutically acceptable acid or base, and methods of treating conditions susceptible to α2-AR/5-HT2C antagonists.

    摘要翻译： 式（I）化合物：其中：R 1和R 2一起形成任选被卤素取代的苯并环，或烷基，烷氧基，氰基，硝基，羟基，氨基，烷基氨基，二烷基氨基或三氟甲基，R R 3和R 4代表氢，或R 1和R 4代表氢，R 2和R 3一起形成任选地被卤素取代的苯并环，或烷基，烷氧基，氰基， 硝基，羟基，氨基，烷基氨基，二烷基氨基或三氟甲基，或R 1和R 2表示氢，R 3和R 4一起形成任选被卤素取代的苯并环，或烷基，烷氧基，氰基 ，硝基，羟基，氨基，烷基氨基，二烷基氨基或三氟甲基，其与药学上可接受的酸或碱的加成盐，以及治疗对α2-AR / 5-HT2C拮抗剂敏感的病症的方法。

    Indoline compounds, a process for their preparation and pharmaceutical compositions containing them
    8.
    发明授权
    Indoline compounds, a process for their preparation and pharmaceutical compositions containing them 失效
    二氢吲哚化合物，其制备方法和含有它们的药物组合物

    公开(公告)号：US06759421B2

    公开(公告)日：2004-07-06

    申请号：US10400358

    申请日：2003-03-27

    申请人： Gilbert Lavielle ,  Olivier Muller ,  Mark Millan ,  Alain Gobert

    发明人： Gilbert Lavielle ,  Olivier Muller ,  Mark Millan ,  Alain Gobert

    IPC分类号： A61K31443

    CPC分类号： C07D401/12

    摘要： A compound of formula (I): wherein: R1 and R2 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, and R3 represents hydrogen, or R1 represents hydrogen, and R2 and R3 together form a benzo ring optionally substituted by halogen or by alkyl, alkoxy, cyano, nitro, hydroxy, amino, alkylamino, dialkylamino or trifluoromethyl, its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicaments.

    摘要翻译： 式（I）化合物：其中：R 1和R 2一起形成任选被卤素取代的苯并环，或烷基，烷氧基，氰基，硝基，羟基，氨基，烷基氨基，二烷基氨基或三氟甲基，R 3表示氢，或R 1表示氢，R 2和R 3一起形成任选被卤素取代的苯并环，或烷基，烷氧基，氰基，硝基，羟基，氨基，烷基氨基，二烷基氨基或 三氟甲基，其对映体，非对映异构体及其与药学上可接受的酸或碱的加成盐，以及药物。

    Cyano-indole serotonin-reuptake inhibitor compounds
    9.
    发明授权
    Cyano-indole serotonin-reuptake inhibitor compounds 失效
    氰基吲哚5-羟色胺再摄取抑制剂化合物

    公开(公告)号：US06239129B1

    公开(公告)日：2001-05-29

    申请号：US09490909

    申请日：2000-01-25

    申请人： Gilbert Lavielle ,  Olivier Muller ,  Bernard Cimetiere ,  Mark Millan ,  Alain Gobert ,  Jean-Michel Rivet

    发明人： Gilbert Lavielle ,  Olivier Muller ,  Bernard Cimetiere ,  Mark Millan ,  Alain Gobert ,  Jean-Michel Rivet

    IPC分类号： A61K31404

    CPC分类号： C07D401/12 ,  C07D209/08 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D513/04

    摘要： Compound of formula (I): wherein: R1 and R2 each independently of the other represents hydrogen or alkyl, A represents alkylene, alkenylene or alkynylene, G1 represents wherein R3 and R4 each independently of the other represents hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, optionally substituted aryl or optionally substituted arylalkyl, or G1 represents heterocycloalkyl optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, nitrile, carboxy, alkoxycarbonyl, carbamoyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl, and which medicinal products containing the same/are useful as serotonin-reuptake inhibitors.

    摘要翻译： 式（I）化合物：其中：R 1和R 2各自独立地表示氢或烷基，A表示亚烷基，亚烯基或亚炔基，G 1表示其中R 3和R 4各自独立地表示氢，烷基，环烷基，环烷基烷基，任选地 取代的芳基或任选取代的芳基烷基，或G 1表示任选被烷基，环烷基，环烷基烷基，腈，羧基，烷氧基羰基，氨基甲酰基，任选取代的芳基，任选取代的芳基烷基，任选取代的杂芳基或任选取代的杂芳基烷基取代的杂环烷基， /作为5-羟色胺再摄取抑制剂是有用的。