-
1.发明授权公开(公告)号：US09410139B2
公开(公告)日：2016-08-09
申请号：US12232250
申请日：2008-09-12
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoît Van Den Eynde , Sandra Morel , Cécile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoît Van Den Eynde , Sandra Morel , Cécile Bauche
CPC分类号： A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C19/06 , F16C25/083 , F16C27/066 , F16C33/7886
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
-
2.发明申请Recombinant adenylate cyclase toxin of bordetella induces T cell responses against tumoral antigens 有权博德特氏菌的重组腺苷酸环化酶毒素诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20090117143A1
公开(公告)日：2009-05-07
申请号：US12232250
申请日：2008-09-12
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
CPC分类号： A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C19/06 , F16C25/083 , F16C27/066 , F16C33/7886
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
-
3.发明申请RECOMBINANT ADENYLATE CYCLASE TOXIN OF BORDETELLA INDUCES T CELL RESPONSES AGAINST TUMORAL ANTIGENS 审中-公开BORDETELLA的重组腺苷酸环化酶诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20100310594A1
公开(公告)日：2010-12-09
申请号：US12731196
申请日：2010-03-25
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
CPC分类号： F16C33/7886 , A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C25/083
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
-
4.发明申请Recombinant adenylate cyclase toxin of Bordetella induces T cell responses against tumoral antigens 审中-公开博德特氏菌的重组腺苷酸环化酶毒素诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20070026022A1
公开(公告)日：2007-02-01
申请号：US11436757
申请日：2006-05-19
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Eynde , Sandra Morel , Cecile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Eynde , Sandra Morel , Cecile Bauche
IPC分类号： A61K39/10 , C07H21/04 , C12N1/21 , C07K14/235 , C12N15/74
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/57 , A61K2039/6068 , C07K14/235 , C07K2319/40 , C12N9/88 , C12Y406/01001
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
-
5.发明申请Recombinant adenylate cyclase toxin of Bordetella induces T cell responses against tumoral antigens 审中-公开博德特氏菌的重组腺苷酸环化酶毒素诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20050271679A1
公开(公告)日：2005-12-08
申请号：US10994204
申请日：2004-11-22
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
IPC分类号： A61K38/16 , A61K39/00 , A61K39/02 , A61K39/385 , A61K39/39 , A61K47/48 , C07H21/04 , C12N1/21 , C12N9/02 , C12N9/88 , C12P21/04
CPC分类号： F16C33/7886 , A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C25/083
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
-
6.发明申请RECOMBINANT ADENYLATE CYCLASE TOXIN OF BORDETELLA INDUCES T CELL RESPONSES AGAINST TUMORAL ANTIGENS 审中-公开BORDETELLA的重组腺苷酸环化酶诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20140227323A1
公开(公告)日：2014-08-14
申请号：US14063164
申请日：2013-10-25
申请人： Gilles DADAGLIO , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecil Bauche
发明人： Gilles DADAGLIO , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecil Bauche
IPC分类号： A61K39/02
CPC分类号： F16C33/7886 , A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C25/083
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
-
7.发明授权Isolated peptides which bind to HLA-B35 molecules, larger peptides which contain these, nucleic acid molecules encoding peptides, and uses thereof 失效结合HLA-B35分子的分离的肽，含有这些肽的较大肽，编码肽的核酸分子及其用途公开(公告)号：US06667037B1
公开(公告)日：2003-12-23
申请号：US09169717
申请日：1998-10-09
IPC分类号： A61K3900
CPC分类号： C12N9/0059 , A61K38/00 , C07K14/70539
摘要： The invention relates to peptides which bind to HLA-B35 molecules, leading to recognition and lysis of the resulting complexes by cytolytic T cells. Also a part of the invention are nucleic acid molecules which encode these peptides, and uses of each of these. The molecules are derived, in some cases, from tyrosinase, and portions of the tyrosinase molecule and portions of nucleic acid molecules which encode tyrosinase are also a part of the invention.
摘要翻译： 本发明涉及与HLA-B35分子结合的肽，导致通过溶细胞T细胞识别和裂解所得复合物。 本发明的一部分也是编码这些肽的核酸分子，以及它们各自的用途。 在一些情况下，分子衍生自酪氨酸酶，酪氨酸酶分子的一部分和编码酪氨酸酶的核酸分子的部分也是本发明的一部分。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.025 秒)
