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1.发明授权公开(公告)号：US09410139B2
公开(公告)日：2016-08-09
申请号：US12232250
申请日：2008-09-12
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoît Van Den Eynde , Sandra Morel , Cécile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoît Van Den Eynde , Sandra Morel , Cécile Bauche
CPC分类号： A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C19/06 , F16C25/083 , F16C27/066 , F16C33/7886
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
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2.发明申请Recombinant adenylate cyclase toxin of bordetella induces T cell responses against tumoral antigens 有权博德特氏菌的重组腺苷酸环化酶毒素诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20090117143A1
公开(公告)日：2009-05-07
申请号：US12232250
申请日：2008-09-12
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
CPC分类号： A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C19/06 , F16C25/083 , F16C27/066 , F16C33/7886
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
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3.发明申请RECOMBINANT ADENYLATE CYCLASE TOXIN OF BORDETELLA INDUCES T CELL RESPONSES AGAINST TUMORAL ANTIGENS 审中-公开BORDETELLA的重组腺苷酸环化酶诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20100310594A1
公开(公告)日：2010-12-09
申请号：US12731196
申请日：2010-03-25
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
CPC分类号： F16C33/7886 , A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C25/083
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
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4.发明申请Recombinant adenylate cyclase toxin of Bordetella induces T cell responses against tumoral antigens 审中-公开博德特氏菌的重组腺苷酸环化酶毒素诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20070026022A1
公开(公告)日：2007-02-01
申请号：US11436757
申请日：2006-05-19
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Eynde , Sandra Morel , Cecile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Eynde , Sandra Morel , Cecile Bauche
IPC分类号： A61K39/10 , C07H21/04 , C12N1/21 , C07K14/235 , C12N15/74
CPC分类号： A61K39/0011 , A61K2039/53 , A61K2039/57 , A61K2039/6068 , C07K14/235 , C07K2319/40 , C12N9/88 , C12Y406/01001
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
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5.发明申请Recombinant adenylate cyclase toxin of Bordetella induces T cell responses against tumoral antigens 审中-公开博德特氏菌的重组腺苷酸环化酶毒素诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20050271679A1
公开(公告)日：2005-12-08
申请号：US10994204
申请日：2004-11-22
申请人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
发明人： Gilles Dadaglio , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecile Bauche
IPC分类号： A61K38/16 , A61K39/00 , A61K39/02 , A61K39/385 , A61K39/39 , A61K47/48 , C07H21/04 , C12N1/21 , C12N9/02 , C12N9/88 , C12P21/04
CPC分类号： F16C33/7886 , A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C25/083
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
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6.发明申请RECOMBINANT ADENYLATE CYCLASE TOXIN OF BORDETELLA INDUCES T CELL RESPONSES AGAINST TUMORAL ANTIGENS 审中-公开BORDETELLA的重组腺苷酸环化酶诱导针对肿瘤抗原的T细胞应答公开(公告)号：US20140227323A1
公开(公告)日：2014-08-14
申请号：US14063164
申请日：2013-10-25
申请人： Gilles DADAGLIO , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecil Bauche
发明人： Gilles DADAGLIO , Claude Leclerc , Daniel Ladant , Benoit Van Den Eynde , Sandra Morel , Cecil Bauche
IPC分类号： A61K39/02
CPC分类号： F16C33/7886 , A61K38/164 , A61K39/0011 , A61K39/099 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/6068 , C12N9/88 , C12Y406/01001 , F16C25/083
摘要： An immunogenic composition comprising a recombinant protein comprising a Bordetella CyaA, or a fragment thereof, and a peptide that corresponds to a tumor antigen is provided as a cancer treatment. Methods of treatment with this immunogenic composition are also provided. In an embodiment, the therapeutic composition is a treatment for melanoma, and comprises epitopes from the HLA*0201 epitope. These epitopes include Tyr or GnT-V, and are present in the recombinant proteins CyaA-E5-Tyr and CyaA-E5-GnT-V.
摘要翻译： 作为癌症治疗，提供了含有包含Bordetella CyaA或其片段的重组蛋白质和对应于肿瘤抗原的肽的免疫原性组合物。 还提供了用该免疫原性组合物治疗的方法。 在一个实施方案中，治疗组合物是黑素瘤的治疗，并且包含来自HLA * 0201表位的表位。 这些表位包括Tyr或GnT-V，并且存在于重组蛋白CyaA-E5-Tyr和CyaA-E5-GnT-V中。
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7.发明授权Modified Bordetella adenylate cyclase comprising or lacking CD11b/CD18 interaction domain and uses thereof 有权包含或缺少CD11b / CD18相互作用结构域的修饰的Bordetella腺苷酸环化酶及其用途公开(公告)号：US07906123B1
公开(公告)日：2011-03-15
申请号：US11713708
申请日：2007-03-05
申请人： Claude Leclerc , Mohammed El-Azami El-Idrissi , Daniel Ladant , Cécile Bauche , Peter Sebo , Jirina Loucka , Radim Osicka
发明人： Claude Leclerc , Mohammed El-Azami El-Idrissi , Daniel Ladant , Cécile Bauche , Peter Sebo , Jirina Loucka , Radim Osicka
CPC分类号： C12N9/88 , A61K39/00 , A61K2039/53 , C12Y406/01001
摘要： The invention relates to modified Bordetella adenylate cyclase toxins which are deficient for CD11b/CD18 binding and to their use in the preparation of pharmaceutical composition for the treatment of whooping cough and/or for the protection against Bordetella infection. The invention also relates to specific fragments of Bordetella adenylate cyclase comprising the CD11b/CD18 interaction domain and their use, especially for targeting a molecule of interest to CD11b expressing cells.
摘要翻译： 本发明涉及对于CD11b / CD18结合缺陷的修饰的博德氏菌属腺苷酸环化酶毒素，以及它们在制备用于治疗百日咳和/或防止博德氏菌感染的药物组合物中的用途。 本发明还涉及包含CD11b / CD18相互作用结构域的博德氏菌属腺苷酸环化酶的特异性片段及其用途，特别是用于将感兴趣的分子靶向CD11b表达细胞。
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8.发明授权Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof therapeutic uses thereof 有权插入腺苷酸环化酶蛋白或其片段的携带人乳头状瘤病毒表位的重组蛋白质的治疗用途公开(公告)号：US08637039B2
公开(公告)日：2014-01-28
申请号：US12977754
申请日：2010-12-23
IPC分类号： A61K39/12 , A61K39/295 , C07K14/235 , C07K14/025
CPC分类号： A61K39/385 , A61K45/06 , A61K2039/525 , A61K2039/6037 , C07K14/005 , C07K14/235 , C07K2319/00 , C12N7/00 , C12N9/88 , C12N2710/20022
摘要： The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains the property of said adenylate cyclase protein to target Antigen Presenting Cells. It also concerns polynucleotides encoding the same. The recombinant protein or the polynucleotide can be used for the design of therapeutic means against HPV infection or against its malignant effects.
摘要翻译： 本发明涉及包含携带一个或多个HPV抗原的一个或多个表位的一个或几个多肽的重组蛋白，所述多肽插入腺苷酸环化酶（CyaA）蛋白或其片段的相同或不同的允许位点，其中 所述CyaA片段保留所述腺苷酸环化酶蛋白质的靶向抗原呈递细胞。 它也涉及编码相同的多核苷酸。 重组蛋白或多核苷酸可用于设计抗HPV感染或其恶性作用的治疗手段。
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9.发明申请Recombinant protein carrying human papillomavirus epitopes inserted in an adenylate cyclase protein or fragment thereof. therapeutic uses thereof 有权携带人乳头状瘤病毒表位的重组蛋白质插入腺苷酸环化酶蛋白或其片段。 其治疗用途公开(公告)号：US20070072266A1
公开(公告)日：2007-03-29
申请号：US11517313
申请日：2006-09-08
CPC分类号： A61K39/385 , A61K45/06 , A61K2039/525 , A61K2039/6037 , C07K14/005 , C07K14/235 , C07K2319/00 , C12N7/00 , C12N9/88 , C12N2710/20022
摘要： The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains the property of said adenylate cyclase protein to target Antigen Presenting Cells. It also concerns polynucleotides encoding the same. The recombinant protein or the polynucleotide can be used for the design of therapeutic means against HPV infection or against its malignant effects.
摘要翻译： 本发明涉及包含携带一个或多个HPV抗原的一个或多个表位的一个或几个多肽的重组蛋白，所述多肽插入腺苷酸环化酶（CyaA）蛋白或其片段的相同或不同的允许位点，其中 所述CyaA片段保留所述腺苷酸环化酶蛋白质的靶向抗原呈递细胞。 它也涉及编码相同的多核苷酸。 重组蛋白或多核苷酸可用于设计抗HPV感染或其恶性作用的治疗手段。
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10.发明申请RECOMBINANT PROTEIN CARRYING HUMAN PAPILLOMAVIRUS EPITOPES INSERTED IN AN ADENYLATE CYCLASE PROTEIN OR FRAGMENT THEREOF THERAPEUTIC USES THEREOF 有权重组蛋白携带人腺病毒外周血单核细胞插入腺苷酸蛋白或其片段，其治疗用途公开(公告)号：US20110171244A1
公开(公告)日：2011-07-14
申请号：US12977754
申请日：2010-12-23
IPC分类号： A61K39/12 , C12Q1/34 , C12N9/99 , C12N9/14 , C12N1/21 , C12N15/63 , A61K38/00 , A61K31/7088 , C07H21/04 , A61P31/12 , A61P37/02 , A61P35/00
CPC分类号： A61K39/385 , A61K45/06 , A61K2039/525 , A61K2039/6037 , C07K14/005 , C07K14/235 , C07K2319/00 , C12N7/00 , C12N9/88 , C12N2710/20022
摘要： The invention relates to a recombinant protein comprising one or several polypeptides bearing one or several epitopes of one or several HPV antigens, said polypeptides being inserted in the same or different permissive sites of an adenylate cyclase (CyaA) protein or of a fragment thereof, wherein said CyaA fragment retains the property of said adenylate cyclase protein to target Antigen Presenting Cells. It also concerns polynucleotides encoding the same. The recombinant protein or the polynucleotide can be used for the design of therapeutic means against HPV infection or against its malignant effects.
摘要翻译： 本发明涉及包含携带一个或多个HPV抗原的一个或多个表位的一个或几个多肽的重组蛋白，所述多肽插入腺苷酸环化酶（CyaA）蛋白或其片段的相同或不同的允许位点，其中 所述CyaA片段保留所述腺苷酸环化酶蛋白质的靶向抗原呈递细胞。 它也涉及编码相同的多核苷酸。 重组蛋白或多核苷酸可用于设计抗HPV感染或其恶性作用的治疗手段。
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