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1.发明授权公开(公告)号：US08987424B2
公开(公告)日：2015-03-24
申请号：US12101999
申请日：2008-04-13
申请人： Gillian Payne , Philip Chun , Daniel J. Tavares
发明人： Gillian Payne , Philip Chun , Daniel J. Tavares
CPC分类号： C07K16/3092 , A61K31/537 , A61K39/39558 , A61K47/6803 , A61K47/6809 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6869 , A61K47/6877 , A61K2039/505 , C07K14/4727 , C07K14/4748 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/464 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要： Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.
摘要翻译： 公开了包含细胞结合剂和细胞毒性剂的细胞毒性缀合物，包含缀合物的治疗组合物，用于抑制细胞生长和治疗疾病的方法，以及包含细胞毒性缀合物的试剂盒是本发明的所有实施方案 。 特别地，细胞结合剂是识别和结合CA6糖底骨的单克隆抗体及其表位结合片段。 本发明还涉及DS6，抗CA6鼠单克隆抗体及其表位结合片段的人源化或重新表达的形式。
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2.发明申请公开(公告)号：US20110064733A1
公开(公告)日：2011-03-17
申请号：US12912107
申请日：2010-10-26
申请人： Gillian PAYNE , Philip Chun , Daniel J. Tavares
发明人： Gillian PAYNE , Philip Chun , Daniel J. Tavares
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/63 , C07K16/30 , C07K14/52 , C07K14/555 , C07K14/475 , C07K14/79 , C12N5/09 , A61P35/00
CPC分类号： C07K16/3092 , A61K31/537 , A61K39/39558 , A61K47/6803 , A61K47/6809 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6869 , A61K47/6877 , A61K2039/505 , C07K14/4727 , C07K14/4748 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/464 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要： Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.
摘要翻译： 公开了包含细胞结合剂和细胞毒性剂的细胞毒性缀合物，包含缀合物的治疗组合物，用于抑制细胞生长和治疗疾病的方法，以及包含细胞毒性缀合物的试剂盒是本发明的所有实施方案 。 特别地，细胞结合剂是识别和结合CA6糖底骨的单克隆抗体及其表位结合片段。 本发明还涉及DS6，抗CA6鼠单克隆抗体及其表位结合片段的人源化或重新表达的形式。
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3.发明申请公开(公告)号：US20090099336A1
公开(公告)日：2009-04-16
申请号：US12101999
申请日：2008-04-13
申请人： Gillian PAYNE , Philip Chun , Daniel J. Tavares
发明人： Gillian PAYNE , Philip Chun , Daniel J. Tavares
IPC分类号： C07K14/555 , C07K16/46 , C07K14/79
CPC分类号： C07K16/3092 , A61K31/537 , A61K39/39558 , A61K47/6803 , A61K47/6809 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6869 , A61K47/6877 , A61K2039/505 , C07K14/4727 , C07K14/4748 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/464 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要： Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.
摘要翻译： 公开了包含细胞结合剂和细胞毒性剂的细胞毒性缀合物，包含缀合物的治疗组合物，用于抑制细胞生长和治疗疾病的方法，以及包含细胞毒性缀合物的试剂盒是本发明的所有实施方案 。 特别地，细胞结合剂是识别和结合CA6糖底骨的单克隆抗体及其表位结合片段。 本发明还涉及DS6，抗CA6鼠单克隆抗体及其表位结合片段的人源化或重新表达的形式。
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4.发明授权公开(公告)号：US07834155B2
公开(公告)日：2010-11-16
申请号：US11213046
申请日：2005-08-29
申请人： Gillian Payne , Philip Chun , Daniel J. Tavares
发明人： Gillian Payne , Philip Chun , Daniel J. Tavares
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , C12P21/04 , C07H21/04
CPC分类号： C07K16/3092 , A61K31/537 , A61K39/39558 , A61K47/6803 , A61K47/6809 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6869 , A61K47/6877 , A61K2039/505 , C07K14/4727 , C07K14/4748 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/464 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要： Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.
摘要翻译： 公开了包含细胞结合剂和细胞毒性剂的细胞毒性缀合物，包含缀合物的治疗组合物，用于抑制细胞生长和治疗疾病的方法，以及包含细胞毒性缀合物的试剂盒是本发明的所有实施方案 。 特别地，细胞结合剂是识别和结合CA6糖底骨的单克隆抗体及其表位结合片段。 本发明还涉及DS6，抗CA6鼠单克隆抗体及其表位结合片段的人源化或重新表达的形式。
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公开(公告)号：US09370584B2
公开(公告)日：2016-06-21
申请号：US12912107
申请日：2010-10-26
申请人： Gillian Payne , Daniel J. Tavares
发明人： Gillian Payne , Philip Chun , Daniel J. Tavares
IPC分类号： A61K39/00 , A61K47/48 , C07K14/47 , C07K16/30 , A61K39/395
CPC分类号： C07K16/3092 , A61K31/537 , A61K39/39558 , A61K47/6803 , A61K47/6809 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6869 , A61K47/6877 , A61K2039/505 , C07K14/4727 , C07K14/4748 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/464 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要： Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.
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公开(公告)号：US07202346B2
公开(公告)日：2007-04-10
申请号：US10612090
申请日：2003-07-03
申请人： Gillian Payne , Thomas Chittenden , Viktor Goldmakher , Philip Chun , Kristin Sneider-Mulready , Carol A. Vater
发明人： Gillian Payne , Thomas Chittenden , Viktor Goldmakher , Philip Chun , Kristin Sneider-Mulready , Carol A. Vater
IPC分类号： C07K16/00
CPC分类号： G01N33/57415 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K16/28 , C07K16/3092 , C07K2317/34 , C07K2317/77 , C07K2317/92 , G01N33/57449 , G01N2333/4725
摘要： The present invention relates to antibodies, antibody fragments, conjugates of antibodies and antibody fragments with cytotoxic agents, and hybridomas producing the antibodies and antibody fragments, where the antibodies and antibody fragments recognize extracellular epitopes of plasma membrane proteins that are not released into the extracellular fluid, and to methods for the detection, monitoring and treatment of malignancies such as breast cancer and ovarian cancer using the antibodies, antibody fragments and conjugates.
摘要翻译： 本发明涉及抗体，抗体片段，抗体的缀合物和具有细胞毒性剂的抗体片段，以及产生抗体和抗体片段的杂交瘤，其中抗体和抗体片段识别未释放到细胞外液中的质膜蛋白的细胞外表位 以及使用抗体，抗体片段和缀合物检测，监测和治疗诸如乳腺癌和卵巢癌的恶性肿瘤的方法。
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7.发明申请公开(公告)号：US20070041980A1
公开(公告)日：2007-02-22
申请号：US11213046
申请日：2005-08-29
申请人： Gillian Payne , Philip Chun , Daniel Tavares
发明人： Gillian Payne , Philip Chun , Daniel Tavares
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C07K16/30 , C12N5/06
CPC分类号： C07K16/3092 , A61K31/537 , A61K39/39558 , A61K47/6803 , A61K47/6809 , A61K47/6851 , A61K47/6855 , A61K47/6859 , A61K47/6869 , A61K47/6877 , A61K2039/505 , C07K14/4727 , C07K14/4748 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/464 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/92
摘要： Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.
摘要翻译： 公开了包含细胞结合剂和细胞毒性剂的细胞毒性缀合物，包含缀合物的治疗组合物，用于抑制细胞生长和治疗疾病的方法，以及包含细胞毒性缀合物的试剂盒是本发明的所有实施方案 。 特别地，细胞结合剂是识别和结合CA6糖底骨的单克隆抗体及其表位结合片段。 本发明还涉及DS6，抗CA6鼠单克隆抗体及其表位结合片段的人源化或重新表达的形式。
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8.发明申请公开(公告)号：US20050123549A1
公开(公告)日：2005-06-09
申请号：US10895135
申请日：2004-07-21
申请人： Gillian Payne , Philip Chun , Daniel Tavares
发明人： Gillian Payne , Philip Chun , Daniel Tavares
IPC分类号： A61K20060101 , A61K39/395 , A61K47/48 , C07H21/04 , C07K14/47 , C07K16/00 , C07K16/30 , C12N5/06 , C12P21/06
CPC分类号： C07K14/4748 , A61K47/6803 , A61K47/6809 , A61K47/6851 , A61K2039/505 , C07K14/4727 , C07K16/3092 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.
摘要翻译： 公开了包含细胞结合剂和细胞毒性剂的细胞毒性缀合物，包含缀合物的治疗组合物，用于抑制细胞生长和治疗疾病的方法，以及包含细胞毒性缀合物的试剂盒是本发明的所有实施方案 。 特别地，细胞结合剂是识别和结合CA6糖底骨的单克隆抗体及其表位结合片段。 本发明还涉及DS6，抗CA6鼠单克隆抗体及其表位结合片段的人源化或重新表达的形式。
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