公开(公告)号：US20100106076A1

公开(公告)日：2010-04-29

申请号：US12593123

申请日：2008-03-21

申请人： Giovanni Nisato ,  Roelf Kassies ,  Johannes Johanna Van Herk

发明人： Giovanni Nisato ,  Roelf Kassies ,  Johannes Johanna Van Herk

IPC分类号： A61M31/00 ,  A61N1/30

CPC分类号： A61M5/142 ,  A61M5/1723 ,  A61M2205/3592 ,  A61M2230/63

摘要： It is described a drug delivery system (100) that is adapted to infuse a drug in a profile related to the activity status of a patient (595). The system comprises acceleration sensors (112), dedicated electronics (120) and software to monitor the patient's activity and maintain control over the drug-release profile. The described system (100) enables a personalized treatment of patients (595) by monitoring their individual activity status and coupling this information to a drug delivery following appropriate delivery profiles. The system (100) may be provided with a memory in order to store a time dependence of activity data. This time dependence may be used by physicians to monitor, support and adapt their therapy for the patients. The system (100) maybe realized as a closed-loop system for monitoring and treatment of various diseases such as Parkinson s disease. Accelerations sensors (112) may be used in order to directly monitor a positional state and/or motions of the patient's body. The described system may allow for a more efficient use of the delivered drugs. This will result both in a reduction of the amount of required medication and a reduction of power required by the system (100).

摘要翻译： 描述了适于在与患者的活动状态相关的轮廓中注入药物的药物递送系统（100）（595）。 该系统包括加速度传感器（112），专用电子设备（120）和用于监视患者活动并维持对药物释放特征的控制的软件。 所描述的系统（100）能够通过监视患者的个体活动状态来对患者进行个性化治疗（595），并将该信息与适当的递送概况的药物递送联系起来。 系统（100）可以设置有存储器，以便存储活动数据的时间依赖性。 这种时间依赖可以由医生使用来监测，支持和适应患者的治疗。 系统（100）可以被实现为用于监测和治疗诸如帕金森病的各种疾病的闭环系统。 可以使用加速度传感器（112）以直接监视患者身体的位置状态和/或运动。 所描述的系统可以允许更有效地使用递送的药物。 这将导致所需药物的量的减少和系统所需的功率的减少（100）。

公开(公告)号：US10518106B2

公开(公告)日：2019-12-31

申请号：US12433135

申请日：2009-04-30

申请人： Michiel Errit Roersma ,  Antonius Maarten Nuijs ,  Francesco Roosen ,  Paul Anton Josef Ackermans ,  Rieko Verhagen ,  Gerhardus Wilhelmus Lucassen ,  Johannes Johanna Van Herk

发明人： Michiel Errit Roersma ,  Antonius Maarten Nuijs ,  Francesco Roosen ,  Paul Anton Josef Ackermans ,  Rieko Verhagen ,  Gerhardus Wilhelmus Lucassen ,  Johannes Johanna Van Herk

IPC分类号： A61N5/06

摘要： The present invention discloses a device and a method for controlling growth of hair on human skin with low doses of electromagnetic radiation, and a device for carrying out the method. In the method, radiation of a suitable spectrum is applied to the skin, in one or more pulses of between 1 and 100 ms, and with maximum fluencies on the skin between 1 and 12 J/cm2. By applying such low fluencies and at controlled pulse durations, follicles of the hairs are induced to the catagen phase. This means that the growth of the hairs of those follicles will stop. Although the method is not primarily aimed at immediate hair removal, hairs may be shed subsequently. In any case, further growth may be stopped for prolonged periods of time. The main advantage of the method is that the risk of damage to the skin is minimized.

公开(公告)号：US08145318B2

公开(公告)日：2012-03-27

申请号：US11997783

申请日：2006-07-20

申请人： Johannes Johanna Van Herk

发明人： Johannes Johanna Van Herk

IPC分类号： A61N1/36

CPC分类号： A61N1/36003 ,  A61N1/0452 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/08

摘要： An apparatus (1) for electrical stimulation of muscle tissue. The apparatus has an electrode system (10) with an electrode array (13). The array has a plurality of electrode pads (12) and can be placed in electrical contact with the muscle tissue. The electrode system Further has a sensor (30; 31-36) for sensing a property of the muscle tissue. The property forms a measure for the activity of the muscle tissue. The apparatus (1) has an electrode selector (530) for selecting one or more stimulating electrode pads. A signal generator (531) is connected to the electrode array (13) for providing an electrical stimulation signal to the stimulation electrode pad. A signal processor (532) is connected to said sensor (30; 31-36), for determining from the sensor signal a value of the muscle activity and outputting the value in a for humans perceptible form. This reduces the accuracy required to position the electrode system (10) and increases the accuracy of measuring the muscle tissue activity.

摘要翻译： 一种用于电刺激肌肉组织的装置（1）。 该装置具有带有电极阵列（13）的电极系统（10）。 阵列具有多个电极焊盘（12），并且可以与肌肉组织电接触。 电极系统还具有用于感测肌肉组织的性质的传感器（30; 31-36）。 该属性形成肌肉组织活动的度量。 设备（1）具有用于选择一个或多个刺激电极焊盘的电极选择器（530）。 信号发生器（531）连接到电极阵列（13），用于向刺激电极焊盘提供电刺激信号。 信号处理器（532）连接到所述传感器（30; 31-36），用于从传感器信号确定肌肉活动的值，并输出人类可感知形式的值。 这降低了定位电极系统（10）所需的精度并且提高了测量肌肉组织活动的准确性。

公开(公告)号：US07551354B2

公开(公告)日：2009-06-23

申请号：US10545988

申请日：2004-02-09

申请人： Jan B. A. M. Horsten ,  Johannes Johanna Van Herk ,  Markus Cornelis Jakobus Lazeroms

发明人： Jan B. A. M. Horsten ,  Johannes Johanna Van Herk ,  Markus Cornelis Jakobus Lazeroms

IPC分类号： G02B27/28

CPC分类号： G09F13/12 ,  A47F2007/195 ,  A47G1/02 ,  G02B5/08 ,  G02F1/133536

摘要： A mirror device which can be simultaneously used for display purposes, based on e.g. an LCD display with a polarizing mirror placed in front of it. The polarizing mirror has the characteristics that it does not disturb the transmission of the light from the display, but does reflect the light from outside the area of the screen. The polarizing mirror is embedded in a conventional mirror.

摘要翻译： 可以同时用于显示目的的反射镜装置， 具有放置在其前面的偏振镜的LCD显示器。 偏光镜具有不会影响来自显示器的光的透射，而是反射来自屏幕外部的光的特性。 偏光镜嵌入传统的镜子中。

公开(公告)号：US20110066209A1

公开(公告)日：2011-03-17

申请号：US12992110

申请日：2009-05-14

申请人： Maarten Peter Bodlaender ,  Alexander Franciscus Kolen ,  Johannes Johanna Van Herk ,  Mirelva M. Drost ,  Femke Wagemakers

发明人： Maarten Peter Bodlaender ,  Alexander Franciscus Kolen ,  Johannes Johanna Van Herk ,  Mirelva M. Drost ,  Femke Wagemakers

IPC分类号： A61N1/34

CPC分类号： A61N1/36021 ,  A61N1/0456

摘要： The invention relates to a device (10) for applying transcutaneous electrical nerve stimulation via an electrode (22), and to a method of transcutaneous electrical nerve stimulation. The device comprises the electrode being arranged for detecting a change of a skin impedance and being configured for switching from a stimulation mode of operation (30) for stimulating the nerve into a recalibration mode of operation (32) upon detection of the changed skin impedance. In an embodiment, the device comprises a plurality of electrodes being configured for detecting the change of the skin impedance and being configured for adjusting an electrical current flowing through the skin via the plurality of electrodes.

摘要翻译： 本发明涉及一种用于经由电极（22）施加经皮电神经刺激的装置（10），以及经皮神经电刺激的方法。 该装置包括电极，其布置成用于检测皮肤阻抗的变化，并且被配置用于从检测到改变的皮肤阻抗的刺激操作模式（30）切换，用于将神经刺激进入重新校准操作模式（32）。 在一个实施例中，该装置包括多个电极，其被配置用于检测皮肤阻抗的变化，并被配置为经由多个电极调节流过皮肤的电流。

公开(公告)号：US20100087903A1

公开(公告)日：2010-04-08

申请号：US12518647

申请日：2007-12-12

申请人： Johannes Johanna Van Herk ,  Marjolein Irene Van Lieshout ,  Femke Wagemakers ,  Alexander Franciscus Kolen ,  Maarten Peter Bodlaender ,  Mirelva Maria Drost

发明人： Johannes Johanna Van Herk ,  Marjolein Irene Van Lieshout ,  Femke Wagemakers ,  Alexander Franciscus Kolen ,  Maarten Peter Bodlaender ,  Mirelva Maria Drost

IPC分类号： A61N1/04

CPC分类号： A61N1/0456 ,  A61B5/0531 ,  A61B5/063 ,  A61H39/002 ,  A61H39/02 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/32 ,  A61N1/36021 ,  A61N2001/083

摘要： The invention provides an electro-therapeutic device for application on a human or animal body part, comprising electrodes (3), a measuring means connected thereto and arranged to measure a value of an electrical quantity, and a control unit (10) to process the measured values, wherein the control unit (10) further comprises pattern recognition means to determine a pattern in the measured values, for example by comparing with patterns stored in a memory unit (15). By means of the determined pattern, the device is able to know its position on the body, and to determine whether this position is suitable for a treatment, and to which electrodes a treatment signal must be supplied. The device is much easier to use since it does not require any user's knowledge about patterns, as this may be stored in the device itself.

摘要翻译： 本发明提供一种用于人体或动物身体部位的电疗装置，包括电极（3），连接到其上并被设置为测量电量值的测量装置，以及控制单元（10） 测量值，其中所述控制单元（10）还包括模式识别装置，以例如通过与存储在存储器单元（15）中的模式进行比较来确定测量值中的模式。 通过确定的图案，该装置能够知道其在身体上的位置，并且确定该位置是否适合于治疗，以及哪个电极必须提供治疗信号。 该设备更容易使用，因为它不需要任何用户对模式的了解，因为这可能存储在设备本身中。

公开(公告)号：US20090118790A1

公开(公告)日：2009-05-07

申请号：US11997783

申请日：2006-07-20

申请人： Johannes Johanna Van Herk

发明人： Johannes Johanna Van Herk

IPC分类号： A61N1/36

CPC分类号： A61N1/36003 ,  A61N1/0452 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/08

摘要： An apparatus (1) for electrical stimulation of muscle tissue. The apparatus has an electrode system (10) with an electrode array (13). The array has a plurality of electrode pads (12) and can be placed in electrical contact with the muscle tissue. The electrode system Further has a sensor (30; 31-36) for sensing a property of the muscle tissue. The property forms a measure for the activity of the muscle tissue. The apparatus (1) has an electrode selector (530) for selecting one or more stimulating electrode pads. A signal generator (531) is connected to the electrode array (13) for providing an electrical stimulation signal to the stimulation electrode pad. A signal processor (532) is connected to said sensor (30; 31-36), for determining from the sensor signal a value of the muscle activity and outputting the value in a for humans perceptible form. This reduces the accuracy required to position the electrode system (10) and increases the accuracy of measuring the muscle tissue activity.

摘要翻译： 一种用于电刺激肌肉组织的装置（1）。 该装置具有带有电极阵列（13）的电极系统（10）。 阵列具有多个电极焊盘（12），并且可以与肌肉组织电接触。 电极系统还具有用于感测肌肉组织的性质的传感器（30; 31-36）。 该属性形成肌肉组织活动的度量。 设备（1）具有用于选择一个或多个刺激电极焊盘的电极选择器（530）。 信号发生器（531）连接到电极阵列（13），用于向刺激电极焊盘提供电刺激信号。 信号处理器（532）连接到所述传感器（30; 31-36），用于从传感器信号确定肌肉活动的值，并输出人类可感知形式的值。 这降低了定位电极系统（10）所需的精度并且提高了测量肌肉组织活动的准确性。

公开(公告)号：US07379243B2

公开(公告)日：2008-05-27

申请号：US10507730

申请日：2003-02-17

申请人： Jan Baptist Adrianus Maria Horsten ,  Markus Cornelis Jakobus Lazeroms ,  Dirk Jan Broer ,  Johannes Johanna Van Herk ,  Hugo Johan Cornelissen

发明人： Jan Baptist Adrianus Maria Horsten ,  Markus Cornelis Jakobus Lazeroms ,  Dirk Jan Broer ,  Johannes Johanna Van Herk ,  Hugo Johan Cornelissen

IPC分类号： G02B5/30

CPC分类号： G02B5/08 ,  G02F1/133536 ,  G02F2001/133638 ,  G09F13/12

摘要： A mirror device (1) which can be simultaneously used for display purposes, based on e.g. an LCD display (5) with a polarizing mirror (2) placed in front of it. The polarizing mirror (2) has the characteristics that it does not disturb the transmission of the light from the display (5), but does reflect the light from outside the area of the screen.

摘要翻译： 可以同时用于显示目的的镜装置（1） 具有放置在其前面的偏振镜（2）的LCD显示器（5）。 偏振镜（2）具有不会影响来自显示器（5）的光的透射，而是反射来自屏幕的外部的光的特性。

公开(公告)号：US08996100B2

公开(公告)日：2015-03-31

申请号：US10509239

申请日：2003-03-06

申请人： Johannes Johanna Van Herk ,  Markus Cornelis Jakobus Lazeroms

发明人： Johannes Johanna Van Herk ,  Markus Cornelis Jakobus Lazeroms

IPC分类号： A61N1/05 ,  A61B5/00 ,  A61B5/0408

CPC分类号： A61B5/6804 ,  A61B5/04085

摘要： An electrode structure for use with a monitoring system. A thin flexible body of an electrode material comprising conductive rubber is provided with projections extending externally to a working surface. According to this construction of the working surface of the electrode only the projections make a contact to the recipient's skin. When the projections are provided with a small cross-section, the constant electrode-skin contact is ensured due to the resiliency of the electrode material.

摘要翻译： 一种用于监控系统的电极结构。 包括导电橡胶的电极材料的柔性柔性体设置有在工作表面外部延伸的凸起。 根据电极工作面的这种结构，只有突起与受体的皮肤接触。 当突起设置有小的横截面时，由于电极材料的弹性，确保了恒定电极 - 皮肤接触。

公开(公告)号：US08620434B2

公开(公告)日：2013-12-31

申请号：US12992110

申请日：2009-05-14

申请人： Maarten Peter Bodlaender ,  Alexander Franciscus Kolen ,  Johannes Johanna Van Herk ,  Mirelva M. Drost ,  Femke Wagemakers

发明人： Maarten Peter Bodlaender ,  Alexander Franciscus Kolen ,  Johannes Johanna Van Herk ,  Mirelva M. Drost ,  Femke Wagemakers

IPC分类号： A61N1/32

CPC分类号： A61N1/36021 ,  A61N1/0456

摘要： A device and method for applying transcutaneous electrical nerve stimulation via an electrode. The device includes the electrode being arranged for detecting a change of a skin impedance and being configured for switching from a stimulation mode of operation for stimulating the nerve, into a recalibration mode of operation upon detection of the changed skin impedance. The device may include a plurality of electrodes being configured for detecting the change of the skin impedance and being configured for adjusting an electrical current flowing through the skin via the plurality of electrodes.

摘要翻译： 经由电极施加经皮电神经刺激的装置和方法。 该装置包括电极，其布置成用于检测皮肤阻抗的变化，并且被配置为在检测到改变的皮肤阻抗时从用于刺激神经的刺激操作模式切换到重新校准操作模式。 该装置可以包括多个电极，其被配置用于检测皮肤阻抗的变化，并被配置为经由多个电极调节流过皮肤的电流。