公开(公告)号：US08802417B2

公开(公告)日：2014-08-12

申请号：US11879422

申请日：2007-07-16

申请人： Giuseppe Marzio ,  Maria Grazia Pau ,  Dirk Jan Elbertus Opstelten ,  Alphonsus Gerardus Cornelis Maria Uytdehaag

发明人： Giuseppe Marzio ,  Maria Grazia Pau ,  Dirk Jan Elbertus Opstelten ,  Alphonsus Gerardus Cornelis Maria Uytdehaag

IPC分类号： C12N7/00 ,  C12N7/02 ,  C12N7/04

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/525 ,  C12N7/00 ,  C12N2760/16021 ,  C12N2760/16022 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16221 ,  C12N2760/16222 ,  C12N2760/16234

摘要： The present invention discloses methods for producing and/or propagating virus particles, such as influenza virus particles, that are present in a virus isolate obtained from an infected subject by contacting a host cell with a virus particle and culturing the cell under conditions conducive to propagation of the virus particle. The invention also provides a method for selective propagation of a set of virus particles, such as influenza virus particles present in an influenza isolate, which have an affinity for receptors comprising a specific glycosylation residue.

摘要翻译： 本发明公开了通过使宿主细胞与病毒颗粒接触并在有利于繁殖的条件下培养该细胞的方法，用于生产和/或繁殖病毒颗粒（例如流感病毒颗粒），其存在于受感染的受试者获得的病毒分离物中 的病毒颗粒。 本发明还提供了一种用于选择性繁殖一组病毒颗粒的方法，所述病毒颗粒如流感病毒分离物中存在的流感病毒颗粒对于包含特定糖基化残基的受体具有亲和性。

公开(公告)号：US07504248B2

公开(公告)日：2009-03-17

申请号：US10497832

申请日：2002-12-09

申请人： Giuseppe Marzio ,  Maria Grazia Pau ,  Dirk Jan Elbertus Opstelten ,  Alphonsus Gerardus Cornelis Maria Uytdehaag

发明人： Giuseppe Marzio ,  Maria Grazia Pau ,  Dirk Jan Elbertus Opstelten ,  Alphonsus Gerardus Cornelis Maria Uytdehaag

IPC分类号： C12N7/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/525 ,  C12N7/00 ,  C12N2760/16021 ,  C12N2760/16022 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16221 ,  C12N2760/16222 ,  C12N2760/16234

摘要： The present invention discloses methods for producing and/or propagating virus particles, such as influenza virus particles, that are present in a virus isolate obtained from an infected subject by contacting a host cell with a virus particle and culturing the cell under conditions conducive to propagation of the virus particle. The invention also provides a method for selective propagation of a set of virus particles, such as influenza virus particles present in an influenza isolate, which have an affinity for receptors comprising a specific glycosylation residue.

摘要翻译： 本发明公开了通过使宿主细胞与病毒颗粒接触并在有利于繁殖的条件下培养该细胞的方法，用于生产和/或繁殖病毒颗粒（例如流感病毒颗粒），其存在于受感染的受试者获得的病毒分离物中 的病毒颗粒。 本发明还提供了一种用于选择性繁殖一组病毒颗粒的方法，所述病毒颗粒如流感病毒分离物中存在的流感病毒颗粒对于包含特定糖基化残基的受体具有亲和性。