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公开(公告)号：US11773395B1
公开(公告)日：2023-10-03
申请号：US18065243
申请日：2022-12-13
发明人： Andrew Geall
IPC分类号： C12N15/117 , C12N15/86 , A61K39/155 , A61K39/39 , A61K39/12 , A61P31/12 , A61P37/04 , A61K48/00 , A61K39/00
CPC分类号： C12N15/117 , A61K39/12 , A61K39/155 , A61K39/39 , A61K48/0041 , A61K48/0083 , A61P31/12 , A61P37/04 , C12N15/86 , A61K2039/53 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C12N2760/18534 , C12N2770/36143 , C12N2820/60
摘要： RNA encoding an immunogen is delivered to a large mammal at a dose of between 2 μg and 100 μg. Thus the invention provides a method of raising an immune response in a large mammal, comprising administering to the mammal a dose of between 2 μg and 100 μg of immunogen-encoding RNA. Similarly, RNA encoding an immunogen can be delivered to a large mammal at a dose of 3 ng/kg to 150 ng/kg. The delivered RNA can elicit an immune response in the large mammal.
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公开(公告)号：US11717529B2
公开(公告)日：2023-08-08
申请号：US18065089
申请日：2022-12-13
IPC分类号： A61K39/00 , A61K39/12 , A61K31/7088
CPC分类号： A61K31/7088 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/55555 , C12N2760/18522 , C12N2760/18534 , C12N2770/36143
摘要： RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.
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公开(公告)号：US20220323354A1
公开(公告)日：2022-10-13
申请号：US17848294
申请日：2022-06-23
发明人： Andrew Geall
IPC分类号： A61K9/127 , A61K39/12 , C12N15/86 , A61K31/7088 , A61K39/00
摘要： Vaccines for eliciting an immune response are provided. The vaccines include lipid nanoparticles comprising lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These lipid nanoparticles can have essentially neutral surface charge at physiological pH and are effective for immunization.
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公开(公告)号：US10238733B2
公开(公告)日：2019-03-26
申请号：US15067216
申请日：2016-03-11
发明人： Luis Brito , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K39/395 , A61K39/385 , A61K9/107 , A61K39/39 , A61K39/00
摘要： This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.
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公开(公告)号：US11905514B2
公开(公告)日：2024-02-20
申请号：US18080164
申请日：2022-12-13
发明人： Andrew Geall
IPC分类号： C12N15/117 , C12N15/86 , A61K39/155 , A61K39/39 , A61K39/12 , A61P31/12 , A61P37/04 , A61K48/00 , A61K39/00
CPC分类号： C12N15/117 , A61K39/12 , A61K39/155 , A61K39/39 , A61K48/0041 , A61K48/0083 , A61P31/12 , A61P37/04 , C12N15/86 , A61K2039/53 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C12N2760/18534 , C12N2770/36143 , C12N2820/60
摘要： RNA encoding an immunogen is delivered to a large mammal at a dose of between 2 μg and 100 μg. Thus the invention provides a method of raising an immune response in a large mammal, comprising administering to the mammal a dose of between 2 μg and 100 μg of immunogen-encoding RNA. Similarly, RNA encoding an immunogen can be delivered to a large mammal at a dose of 3 ng/kg to 150 ng/kg. The delivered RNA can elicit an immune response in the large mammal.
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公开(公告)号：US11891608B2
公开(公告)日：2024-02-06
申请号：US18080150
申请日：2022-12-13
发明人： Andrew Geall
IPC分类号： C12N15/117 , C12N15/86 , A61K39/155 , A61K39/39 , A61K39/12 , A61P31/12 , A61P37/04 , A61K48/00 , A61K39/00
CPC分类号： C12N15/117 , A61K39/12 , A61K39/155 , A61K39/39 , A61K48/0041 , A61K48/0083 , A61P31/12 , A61P37/04 , C12N15/86 , A61K2039/53 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C12N2760/18534 , C12N2770/36143 , C12N2820/60
摘要： RNA encoding an immunogen is delivered to a large mammal at a dose of between 2 μg and 100 μg. Thus, the invention provides a method of raising an immune response in a large mammal, comprising administering to the mammal a dose of between 2 μg and 100 μg of immunogen-encoding RNA. Similarly, RNA encoding an immunogen can be delivered to a large mammal at a dose of 3 ng/kg to 150 ng/kg. The delivered RNA can elicit an immune response in the large mammal.
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公开(公告)号：US11865080B2
公开(公告)日：2024-01-09
申请号：US18065069
申请日：2022-12-13
IPC分类号： A61K39/00 , A61K39/12 , A61K31/7088
CPC分类号： A61K31/7088 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/55555 , C12N2760/18522 , C12N2760/18534 , C12N2770/36143
摘要： RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.
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公开(公告)号：US11851660B2
公开(公告)日：2023-12-26
申请号：US18065267
申请日：2022-12-13
发明人： Andrew Geall
IPC分类号： C12N15/117 , C12N15/86 , A61K39/155 , A61K39/39 , A61K39/12 , A61P31/12 , A61P37/04 , A61K48/00 , A61K39/00
CPC分类号： C12N15/117 , A61K39/12 , A61K39/155 , A61K39/39 , A61K48/0041 , A61K48/0083 , A61P31/12 , A61P37/04 , C12N15/86 , A61K2039/53 , A61K2039/552 , A61K2039/55555 , A61K2039/55566 , C12N2760/18534 , C12N2770/36143 , C12N2820/60
摘要： RNA encoding an immunogen is delivered to a large mammal at a dose of between 2 μg and 100 μg. Thus the invention provides a method of raising an immune response in a large mammal, comprising administering to the mammal a dose of between 2 μg and 100 μg of immunogen-encoding RNA. Similarly, RNA encoding an immunogen can be delivered to a large mammal at a dose of 3 ng/kg to 150 ng/kg. The delivered RNA can elicit an immune response in the large mammal.
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公开(公告)号：US11766401B2
公开(公告)日：2023-09-26
申请号：US17560059
申请日：2021-12-22
发明人： Andrew Geall
CPC分类号： A61K9/127 , A61K9/1272 , A61K31/7088 , A61K39/00 , A61K39/12 , C12N15/86 , A61K39/39 , A61K2039/53 , A61K2039/55555 , C12N2710/16134 , C12N2760/18534 , C12N2770/36134
摘要： RNA encoding an immunogen is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These liposomes can have essentially neutral surface charge at physiological pH and are effective for immunisation.
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公开(公告)号：US11696923B2
公开(公告)日：2023-07-11
申请号：US18080075
申请日：2022-12-13
IPC分类号： A61K39/00 , A61K39/12 , A61K31/7088
CPC分类号： A61K31/7088 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/55555 , C12N2760/18522 , C12N2760/18534 , C12N2770/36143
摘要： RNA encoding an immunogen is co-delivered to non-immune cells as the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g., by a single injection.
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