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公开(公告)号：US10307374B2
公开(公告)日：2019-06-04
申请号：US15495066
申请日：2017-04-24
发明人： Luis Brito , Michelle C. Archer , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K9/107 , A61K39/12 , A61K39/155 , A61K31/713 , A61K9/00 , A61K39/00
摘要： This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.
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公开(公告)号：US10603369B2
公开(公告)日：2020-03-31
申请号：US15887203
申请日：2018-02-02
IPC分类号： A61K39/00 , A61K31/4375 , A61K31/66 , A61K33/06 , A61K39/39 , A61K39/12 , A61K39/102 , A61K39/116 , A61K39/295
摘要： Combination vaccine compositions as well as methods for their manufacture have a relatively low amount of antigen and/or a relatively low amount of aluminium, but they can nevertheless have immunogenicity which is comparable to combination vaccines with a relatively high amount of antigen and/or a relatively high amount of aluminium. Aluminium-free combination vaccine compositions are also provided e.g. compositions which are adjuvanted with an oil-in-water emulsion adjuvant.
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公开(公告)号：US10238733B2
公开(公告)日：2019-03-26
申请号：US15067216
申请日：2016-03-11
发明人： Luis Brito , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K39/395 , A61K39/385 , A61K9/107 , A61K39/39 , A61K39/00
摘要： This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.
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公开(公告)号：US20160375132A1
公开(公告)日：2016-12-29
申请号：US15201651
申请日：2016-07-05
IPC分类号： A61K39/39 , A61K39/12 , A61K31/4745 , A61K39/095 , A61K39/155
CPC分类号： A61K39/39 , A61K31/4745 , A61K31/496 , A61K31/5377 , A61K31/675 , A61K31/683 , A61K31/7004 , A61K31/717 , A61K39/095 , A61K39/12 , A61K39/155 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N2760/14134 , C12N2760/18534 , Y02A50/41 , A61K2300/00
摘要： The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in need thereof. The homogeneous suspensions may be used in combinations with various antigens or adjuvants for vaccine therapies.
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公开(公告)号：US20170224616A1
公开(公告)日：2017-08-10
申请号：US15495066
申请日：2017-04-24
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
CPC分类号： A61K9/107 , A61K9/0019 , A61K31/713 , A61K39/12 , A61K39/155 , A61K2039/53 , A61K2039/55566 , C12N2760/18534 , Y02A50/412 , Y02A50/489
摘要： This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The emulsion particles have an average diameter of about 80 nm to about 180 nm, and the emulsion have an N/P ratio of at least 1.1:1.
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公开(公告)号：US20170202960A1
公开(公告)日：2017-07-20
申请号：US15467660
申请日：2017-03-23
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K39/39 , A61K47/02 , A61K47/12 , C12N7/00 , A61K47/34 , A61K47/22 , A61K39/245 , A61K39/155 , A61K47/06 , A61K47/26
CPC分类号： A61K39/39 , A61K9/1075 , A61K39/12 , A61K39/155 , A61K39/245 , A61K47/02 , A61K47/06 , A61K47/12 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/34 , A61K2039/5256 , A61K2039/53 , A61K2039/55555 , A61K2039/55566 , A61K2039/575 , C12N7/00 , C12N2710/16134 , C12N2710/16171 , C12N2710/16734 , C12N2710/16771 , C12N2760/18534 , C12N2760/18571 , C12N2770/36134 , C12N2770/36143 , C12N2840/203 , Y02A50/386 , Y02A50/388 , Y02A50/412
摘要： This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.
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公开(公告)号：US20160310590A1
公开(公告)日：2016-10-27
申请号：US15201766
申请日：2016-07-05
发明人： Derek O'Hagan , Nicholas Valiante
IPC分类号： A61K39/39 , A61K39/095 , A61K39/21 , A61K39/29 , C12N7/00
CPC分类号： A61K39/39 , A61K39/095 , A61K39/21 , A61K39/29 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , C12N7/00 , C12N2740/16034 , C12N2770/24234
摘要： Adjuvant compositions comprising type 1 interferon inducers, such as double-stranded RNA, in combination with antigen delivery systems and/or immunostimulatory molecules, such as immunostimulatory nucleic acid sequences, for enhancing the immune response of a coadministered antigen, are described.
摘要翻译： 描述了包含1型干扰素诱导剂（例如双链RNA）与抗原递送系统和/或免疫刺激分子（例如免疫刺激性核酸序列）组合的辅助组合物，用于增强共同施用的抗原的免疫应答。
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公开(公告)号：US20180280301A1
公开(公告)日：2018-10-04
申请号：US15981104
申请日：2018-05-16
发明人： Derek O'Hagan , Manmohan Singh , Siddhartha Jain , Padma Malyala
IPC分类号： A61K9/14 , A61K39/095 , A61J1/00 , A61K39/00
摘要： In one aspect, the present invention provides sterile microparticle compositions comprising biodegradable microparticles, which comprise at least one biodegradable polymer. In other aspects, the present invention provides methods of making and using such compositions as well as articles of manufacture and kits containing the same.
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公开(公告)号：US09931399B2
公开(公告)日：2018-04-03
申请号：US15163592
申请日：2016-05-24
发明人： Barbara Baudner , Derek O'Hagan , Manmohan Singh , Simone Bufali
CPC分类号： A61K39/39 , A61K9/107 , A61K39/0018 , A61K39/13 , A61K2039/55505 , A61K2039/55511 , A61K2039/55566 , A61K2039/55572 , C12N7/00 , C12N2770/32634 , Y02A50/466
摘要： The invention improves TdaP vaccines by including a TLR agonist in them. This agonist can provide stronger protection, longer-lasting protection, and/or can reduce the amount of antigen which is required to achieve a particular immune response.
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公开(公告)号：US10183074B2
公开(公告)日：2019-01-22
申请号：US15467660
申请日：2017-03-23
发明人： Luis Brito , Michelle Chan , Andrew Geall , Derek O'Hagan , Manmohan Singh
IPC分类号： A61K9/107 , A61K39/00 , A61K39/12 , A61K47/12 , A61K39/39 , A61K47/06 , A61K47/24 , A61K39/155 , A61K39/245 , A61K47/02 , A61K47/22 , A61K47/26 , A61K47/34 , C12N7/00
摘要： This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are useful for delivering negatively charged molecules, such as nucleic acid molecules to cells, and for formulating nucleic acid-based vaccines.
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