公开(公告)号：US09994529B2

公开(公告)日：2018-06-12

申请号：US15431942

申请日：2017-02-14

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan Bury ,  Linda N. Casillas ,  Adam K. Charnley ,  Michael P. Demartino ,  Xiaoyang Dong ,  Patrick M. Eidam ,  Pamela A. Haile ,  Robert W. Marquis, Jr. ,  Joshi M. Ramanjulu ,  Joseph J. Romano ,  Ami Lakdawala Shah ,  Robert R. Singhaus, Jr. ,  Gren Wang

IPC: C07D239/94 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

CPC classification number: C07D239/94 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US10717711B2

公开(公告)日：2020-07-21

申请号：US16286920

申请日：2019-02-27

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Adam K. Charnley ,  Xiaoyang Dong

IPC: C07D239/94 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US12247033B2

公开(公告)日：2025-03-11

申请号：US18586620

申请日：2024-02-26

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Adam K. Charnley ,  Janos Botyanszki ,  Xiaoyang Dong ,  Philip Gareth Humphreys ,  Bryan Wayne King ,  Kimberly Katherine Marcus ,  Joseph Pero ,  Alexander Joseph Reif ,  Daohua Zhang ,  Attiq Rahman ,  Kenneth Allen Newlander ,  Kenneth Wiggall ,  Joshi Ramanjulu

IPC: C07D487/04 ,  C07D403/14 ,  C07D471/04 ,  C07D471/14 ,  C07F9/6561

Abstract: The present invention relates to compounds of Formula (I), compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.