公开(公告)号：US20250092053A1

公开(公告)日：2025-03-20

申请号：US18966276

申请日：2024-12-03

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Adam K. CHARNLEY ,  Janos Botyanszki ,  Xiaoyang Dong ,  Philip Gareth Humphreys ,  Bryan Wayne King ,  Kimberly Katherine Marcus ,  Joseph Pero ,  Alexander Joseph Reif ,  Daohua Zhang ,  Attiq Rahman ,  Kenneth Allen Newlander ,  Kenneth Wiggall ,  Joshi Ramanjulu

IPC: C07D487/04 ,  C07D403/14 ,  C07D471/04 ,  C07D471/14 ,  C07F9/6561

Abstract: The present invention relates to compounds of Formula (I), compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.

公开(公告)号：US12247033B2

公开(公告)日：2025-03-11

申请号：US18586620

申请日：2024-02-26

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Adam K. Charnley ,  Janos Botyanszki ,  Xiaoyang Dong ,  Philip Gareth Humphreys ,  Bryan Wayne King ,  Kimberly Katherine Marcus ,  Joseph Pero ,  Alexander Joseph Reif ,  Daohua Zhang ,  Attiq Rahman ,  Kenneth Allen Newlander ,  Kenneth Wiggall ,  Joshi Ramanjulu

IPC: C07D487/04 ,  C07D403/14 ,  C07D471/04 ,  C07D471/14 ,  C07F9/6561

Abstract: The present invention relates to compounds of Formula (I), compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.