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公开(公告)号：US20190201413A1
公开(公告)日：2019-07-04
申请号：US16299254
申请日：2019-03-12
发明人： Jae U. JEONG , Deepak Bandyopadhyay , Patrick M. Eidam , Philip Anthony Harris , Jianxing Kang , Bryan Wayne King , Ami Lakdawala Shah , Lara Kathryn Leister , Attiq Rahman , Joshi M. Ramanjulu , Clark A. Sehon , Robert Singhaus, JR. , Daohua Zhang
IPC分类号： A61K31/553 , A61K31/55 , C07D403/12 , C07D223/08 , C07D281/10 , C07D498/04 , C07D413/14 , C07D487/04 , C07D417/12 , C07D413/12 , C07D409/12 , C07D403/14 , C07D267/14
CPC分类号： A61K31/553 , A61K31/55 , C07D223/08 , C07D267/14 , C07D281/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/04 , C07D498/04
摘要： Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.
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公开(公告)号：US20150094333A1
公开(公告)日：2015-04-02
申请号：US14396559
申请日：2013-09-13
发明人： Linda N. Casillas , Michael P. Demartino , Pamela A. Haile , John F. Mehlmann , Joshi M. Ramanjulu , Robert Singhaus, JR.
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Disclosed are compounds having the formula: wherein R1, R2R3, R4 and R5 are as defined herein, and methods of making and using the same.
摘要翻译： 公开了具有下式的化合物：其中R1，R2R3，R4和R5如本文所定义，以及制备和使用它们的方法。
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公开(公告)号：US10975287B2
公开(公告)日：2021-04-13
申请号：US16091945
申请日：2017-04-05
发明人： Adam Kenneth Charnley , Michael G. Darcy , Jason W. Dodson , Terry V. Hughes , Yue Li , Yiqian Lian , Neysa Nevins , Joshi M. Ramanjulu
IPC分类号： C07D401/14 , C07D403/12 , A61P31/18 , C09K8/508 , C09K8/512 , C09K8/516 , E21B33/13 , E21B47/10 , C07D403/14 , C07D413/14
摘要： Disclosed are compounds having the formula: wherein Ra, R1, R2, R3, R4, R5, R6, R7, and R8, are as defined herein, or a salt, particularly a pharmaceutically acceptable salt, thereof.
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公开(公告)号：US11970480B2
公开(公告)日：2024-04-30
申请号：US17663749
申请日：2022-05-17
发明人： Adam Kenneth Charnley , Michael G. Darcy , Jason W. Dodson , Xiaoyang Dong , Terry V. Hughes , Jianxing Kang , Lara Kathryn Leister , Yiqian Lian , Yue Li , John F. Mehlmann , Neysa Nevins , Joshi M. Ramanjulu , Joseph J. Romano , Gren Z. Wang , Guosen Ye , Daohua Zhang
IPC分类号： C07D403/14 , C07D405/14 , C07D413/14 , C07D487/22 , C07D493/10 , C07D498/18 , C07F9/6558
CPC分类号： C07D403/14 , C07D405/14 , C07D413/14 , C07D487/22 , C07D493/10 , C07D498/18 , C07F9/65583
摘要： Disclosed are compounds having the formula:
wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.-
公开(公告)号：US20190262356A1
公开(公告)日：2019-08-29
申请号：US16408718
申请日：2019-05-10
发明人： Jae U. JEONG , Deepak Bandyopadhyay , Patrick M. Eidam , Philip Anthony Harris , Jianxing Kang , Bryan Wayne King , Ami Lakdawala Shah , Lara Kathryn Leister , Attiq Rahman , Joshi M. Ramanjulu , Clark A. Sehon , Robert Singhaus, JR. , Daohua Zhang
IPC分类号： A61K31/553 , C07D413/14 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/55 , C07D267/14 , C07D498/04 , C07D281/10 , C07D223/08 , C07D403/12 , C07D487/04
摘要： Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.
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公开(公告)号：US09994529B2
公开(公告)日：2018-06-12
申请号：US15431942
申请日：2017-02-14
发明人： Michael Jonathan Bury , Linda N. Casillas , Adam K. Charnley , Michael P. Demartino , Xiaoyang Dong , Patrick M. Eidam , Pamela A. Haile , Robert W. Marquis, Jr. , Joshi M. Ramanjulu , Joseph J. Romano , Ami Lakdawala Shah , Robert R. Singhaus, Jr. , Gren Wang
IPC分类号： C07D239/94 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04
CPC分类号： C07D239/94 , C07D403/12 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.
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公开(公告)号：US09216965B2
公开(公告)日：2015-12-22
申请号：US14396559
申请日：2013-09-13
发明人： Linda N. Casillas , Michael P. Demartino , Pamela A. Haile , John F. Mehlmann , Joshi M. Ramanjulu , Robert Singhaus, Jr.
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Disclosed are compounds having the formula: wherein R1, R2R3, R4 and R5 are as defined herein, and methods of making and using the same.
摘要翻译： 公开了具有下式的化合物：其中R1，R2R3，R4和R5如本文所定义，以及制备和使用它们的方法。
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公开(公告)号：US10940154B2
公开(公告)日：2021-03-09
申请号：US16408718
申请日：2019-05-10
发明人： Jae U. Jeong , Deepak Bandyopadhyay , Patrick M. Eidam , Philip Anthony Harris , Jianxing Kang , Bryan Wayne King , Ami Lakdawala Shah , Lara Kathryn Leister , Attiq Rahman , Joshi M. Ramanjulu , Clark A. Sehon , Robert Singhaus, Jr. , Daohua Zhang
IPC分类号： A61K31/553 , A61K31/55 , C07D413/14 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D267/14 , C07D498/04 , C07D281/10 , A61K31/551 , C07D403/12 , C07D223/08
摘要： Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.
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公开(公告)号：US10933070B2
公开(公告)日：2021-03-02
申请号：US16299254
申请日：2019-03-12
发明人： Jae U. Jeong , Deepak Bandyopadhyay , Patrick M. Eidam , Philip Anthony Harris , Jianxing Kang , Bryan Wayne King , Ami Lakdawala Shah , Lara Kathryn Leister , Attiq Rahman , Joshi M. Ramanjulu , Clark A. Sehon , Robert Singhaus, Jr. , Daohua Zhang
IPC分类号： A61K31/55 , A61K31/551 , A61K31/553 , C07D413/14 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D267/14 , C07D498/04 , C07D281/10 , C07D403/12 , C07D223/08
摘要： Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.
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公开(公告)号：US11377440B2
公开(公告)日：2022-07-05
申请号：US16652221
申请日：2018-10-04
发明人： David T. Fosbenner , Todd L. Graybill , Jianxing Kang , Bryan W. King , Yunfeng Lan , Lara Kathryn Leister , Mukesh K. Mahajan , John F. Mehlmann , Angel I. Morales-Ramos , George Scott Pesiridis , Joshi M. Ramanjulu , Joseph J. Romano , Stuart Paul Romeril , Mark J. Schulz , Huiqiang Zhou , Junya Qu
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14
摘要： Disclosed are compounds having the formula: (I) wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, R17, Rx, and Ry are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.
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