公开(公告)号：US10292987B2

公开(公告)日：2019-05-21

申请号：US15459141

申请日：2017-03-15

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Jae U. Jeong ,  Deepak Bandyopadhyay ,  Patrick M. Eidam ,  Philip Anthony Harris ,  Jianxing Kang ,  Bryan Wayne King ,  Ami Lakdawala Shah ,  Lara Kathryn Leister ,  Attiq Rahman ,  Joshi M. Ramanjulu ,  Clark A. Sehon ,  Robert Singhaus, Jr. ,  Daohua Zhang

IPC: A61K31/553 ,  C07D267/14 ,  C07D403/12 ,  C07D413/14 ,  C07D403/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04 ,  C07D281/10 ,  A61K31/55 ,  C07D223/08

Abstract: Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.

公开(公告)号：US20190201413A1

公开(公告)日：2019-07-04

申请号：US16299254

申请日：2019-03-12

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Jae U. JEONG ,  Deepak Bandyopadhyay ,  Patrick M. Eidam ,  Philip Anthony Harris ,  Jianxing Kang ,  Bryan Wayne King ,  Ami Lakdawala Shah ,  Lara Kathryn Leister ,  Attiq Rahman ,  Joshi M. Ramanjulu ,  Clark A. Sehon ,  Robert Singhaus, JR. ,  Daohua Zhang

IPC: A61K31/553 ,  A61K31/55 ,  C07D403/12 ,  C07D223/08 ,  C07D281/10 ,  C07D498/04 ,  C07D413/14 ,  C07D487/04 ,  C07D417/12 ,  C07D413/12 ,  C07D409/12 ,  C07D403/14 ,  C07D267/14

CPC classification number: A61K31/553 ,  A61K31/55 ,  C07D223/08 ,  C07D267/14 ,  C07D281/10 ,  C07D403/12 ,  C07D403/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D487/04 ,  C07D498/04

Abstract: Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.

公开(公告)号：US20250092053A1

公开(公告)日：2025-03-20

申请号：US18966276

申请日：2024-12-03

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Adam K. CHARNLEY ,  Janos Botyanszki ,  Xiaoyang Dong ,  Philip Gareth Humphreys ,  Bryan Wayne King ,  Kimberly Katherine Marcus ,  Joseph Pero ,  Alexander Joseph Reif ,  Daohua Zhang ,  Attiq Rahman ,  Kenneth Allen Newlander ,  Kenneth Wiggall ,  Joshi Ramanjulu

IPC: C07D487/04 ,  C07D403/14 ,  C07D471/04 ,  C07D471/14 ,  C07F9/6561

Abstract: The present invention relates to compounds of Formula (I), compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.

公开(公告)号：US11970480B2

公开(公告)日：2024-04-30

申请号：US17663749

申请日：2022-05-17

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Adam Kenneth Charnley ,  Michael G. Darcy ,  Jason W. Dodson ,  Xiaoyang Dong ,  Terry V. Hughes ,  Jianxing Kang ,  Lara Kathryn Leister ,  Yiqian Lian ,  Yue Li ,  John F. Mehlmann ,  Neysa Nevins ,  Joshi M. Ramanjulu ,  Joseph J. Romano ,  Gren Z. Wang ,  Guosen Ye ,  Daohua Zhang

IPC: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/6558

CPC classification number: C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D487/22 ,  C07D493/10 ,  C07D498/18 ,  C07F9/65583

Abstract: Disclosed are compounds having the formula:






wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

公开(公告)号：US20190262356A1

公开(公告)日：2019-08-29

申请号：US16408718

申请日：2019-05-10

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Jae U. JEONG ,  Deepak Bandyopadhyay ,  Patrick M. Eidam ,  Philip Anthony Harris ,  Jianxing Kang ,  Bryan Wayne King ,  Ami Lakdawala Shah ,  Lara Kathryn Leister ,  Attiq Rahman ,  Joshi M. Ramanjulu ,  Clark A. Sehon ,  Robert Singhaus, JR. ,  Daohua Zhang

IPC: A61K31/553 ,  C07D413/14 ,  C07D403/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/55 ,  C07D267/14 ,  C07D498/04 ,  C07D281/10 ,  C07D223/08 ,  C07D403/12 ,  C07D487/04

Abstract: Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.

公开(公告)号：US12247033B2

公开(公告)日：2025-03-11

申请号：US18586620

申请日：2024-02-26

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Adam K. Charnley ,  Janos Botyanszki ,  Xiaoyang Dong ,  Philip Gareth Humphreys ,  Bryan Wayne King ,  Kimberly Katherine Marcus ,  Joseph Pero ,  Alexander Joseph Reif ,  Daohua Zhang ,  Attiq Rahman ,  Kenneth Allen Newlander ,  Kenneth Wiggall ,  Joshi Ramanjulu

IPC: C07D487/04 ,  C07D403/14 ,  C07D471/04 ,  C07D471/14 ,  C07F9/6561

Abstract: The present invention relates to compounds of Formula (I), compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.

公开(公告)号：US10940154B2

公开(公告)日：2021-03-09

申请号：US16408718

申请日：2019-05-10

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Jae U. Jeong ,  Deepak Bandyopadhyay ,  Patrick M. Eidam ,  Philip Anthony Harris ,  Jianxing Kang ,  Bryan Wayne King ,  Ami Lakdawala Shah ,  Lara Kathryn Leister ,  Attiq Rahman ,  Joshi M. Ramanjulu ,  Clark A. Sehon ,  Robert Singhaus, Jr. ,  Daohua Zhang

IPC: A61K31/553 ,  A61K31/55 ,  C07D413/14 ,  C07D403/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D267/14 ,  C07D498/04 ,  C07D281/10 ,  A61K31/551 ,  C07D403/12 ,  C07D223/08

Abstract: Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.

公开(公告)号：US10933070B2

公开(公告)日：2021-03-02

申请号：US16299254

申请日：2019-03-12

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Jae U. Jeong ,  Deepak Bandyopadhyay ,  Patrick M. Eidam ,  Philip Anthony Harris ,  Jianxing Kang ,  Bryan Wayne King ,  Ami Lakdawala Shah ,  Lara Kathryn Leister ,  Attiq Rahman ,  Joshi M. Ramanjulu ,  Clark A. Sehon ,  Robert Singhaus, Jr. ,  Daohua Zhang

IPC: A61K31/55 ,  A61K31/551 ,  A61K31/553 ,  C07D413/14 ,  C07D403/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D267/14 ,  C07D498/04 ,  C07D281/10 ,  C07D403/12 ,  C07D223/08

Abstract: Disclosed are compounds having the formula: wherein X, Y, Z1, Z2, Z3, Z4, R5, RA, m, A. L, and B are as defined herein, and methods of making and using the same.