公开(公告)号：US20190040051A1

公开(公告)日：2019-02-07

申请号：US16073355

申请日：2017-02-10

申请人： GlaxoSmithKline Intellectual Property Development Limited

发明人： Niall Andrew ANDERSON ,  Nicholas Paul BARTON ,  Sebastien Andre CAMPOS ,  Edward Paul CANNONS ,  Anthony William James COOPER ,  Kenneth David DOWN ,  Kevin James DOYLE ,  Julie Nicole HAMBLIN ,  Graham George Adam INGLIS ,  Armelle LE GALL ,  Vipulkumar Kantibhai PATEL ,  Simon PEACE ,  Andrew SHARPE ,  Gemma Victoria WHITE

IPC分类号： C07D413/14 ,  A61P11/06 ,  A61P25/28 ,  A61P37/08 ,  A61P15/08 ,  A61P25/24

CPC分类号： C07D413/14 ,  A61P11/06 ,  A61P15/08 ,  A61P25/24 ,  A61P25/28 ,  A61P37/08 ,  C07D213/76

摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

公开(公告)号：US20210163472A1

公开(公告)日：2021-06-03

申请号：US16770673

申请日：2018-12-12

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

发明人： Gianpaolo BRAVI ,  Heather HOBBS ,  Graham George Adam INGLIS ,  Simon NICOLLE ,  Simon PEACE

IPC分类号： C07D471/04 ,  A61P11/00 ,  C07D519/00

摘要： The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, L and A are as defined in the description and claims, or pharmaceutically acceptable salts thereof having mTOR kinase inhibitor activity. The invention also relates to pharmaceutical compositions including a compound of formula (I) or a pharmaceutically acceptable salt thereof, and to the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in therapy, including in the treatment of a disease or condition for which an mTOR kinase inhibitor activity is indicated, and in particular the treatment of idiopathic pulmonary fibrosis.

公开(公告)号：US20200071311A1

公开(公告)日：2020-03-05

申请号：US16572917

申请日：2019-09-17

申请人： GlaxoSmithKline Intellectual Property Development Limited

发明人： Niall Andrew ANDERSON ,  Nicholas Paul BARTON ,  Sebastien Andre CAMPOS ,  Edward Paul CANNONS ,  Anthony William James COOPER ,  Kenneth David DOWN ,  Kevin James DOYLE ,  Julie Nicole HAMBLIN ,  Graham George Adam INGLIS ,  Armelle LE GALL ,  Vipulkumar Kantibhai PATEL ,  Simon PEACE ,  Andrew SHARPE ,  Gemma Victoria WHITE

IPC分类号： C07D413/14 ,  A61P15/08 ,  A61P25/24 ,  A61P37/08 ,  A61P11/06 ,  A61P25/28 ,  C07D213/76

摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.