公开(公告)号：US11254671B2

公开(公告)日：2022-02-22

申请号：US16770673

申请日：2018-12-12

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

发明人： Gianpaolo Bravi ,  Heather Hobbs ,  Graham George Adam Inglis ,  Simon Nicolle ,  Simon Peace

IPC分类号： C07D471/04 ,  C07D519/00 ,  A61P11/00

摘要： The invention relates to compounds of formula (I): wherein R1, R2, R3, R4, L and A are as defined in the description and claims, or pharmaceutically acceptable salts thereof having mTOR kinase inhibitor activity. The invention also relates to pharmaceutical compositions including a compound of formula (I) or a pharmaceutically acceptable salt thereof, and to the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof in therapy, including in the treatment of a disease or condition for which an mTOR kinase inhibitor activity is indicated, and in particular the treatment of idiopathic pulmonary fibrosis.

公开(公告)号：US10457674B2

公开(公告)日：2019-10-29

申请号：US16073355

申请日：2017-02-10

申请人： GlaxoSmithKline Intellectual Property Development Limited

发明人： Niall Andrew Anderson ,  Nicholas Paul Barton ,  Sebastien Andre Campos ,  Edward Paul Cannons ,  Anthony William James Cooper ,  Kenneth David Down ,  Kevin James Doyle ,  Julie Nicole Hamblin ,  Graham George Adam Inglis ,  Armelle Le Gall ,  Vipulkumar Kantibhai Patel ,  Simon Peace ,  Andrew Sharpe ,  Gemma Victoria White

IPC分类号： C07D413/14 ,  C07D213/76 ,  A61P25/28 ,  A61P11/06 ,  A61P37/08 ,  A61P25/24 ,  A61P15/08

摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

公开(公告)号：US10793559B2

公开(公告)日：2020-10-06

申请号：US16572917

申请日：2019-09-17

申请人： GlaxoSmithKline Intellectual Property Development Limited

发明人： Niall Andrew Anderson ,  Nicholas Paul Barton ,  Sebastien Andre Campos ,  Edward Paul Cannons ,  Anthony William James Cooper ,  Kenneth David Down ,  Kevin James Doyle ,  Julie Nicole Hamblin ,  Graham George Adam Inglis ,  Armelle Le Gall ,  Vipulkumar Kantibhai Patel ,  Simon Peace ,  Andrew Sharpe ,  Gemma Victoria White

IPC分类号： C07D413/14 ,  C07D213/76 ,  A61P25/28 ,  A61P11/06 ,  A61P37/08 ,  A61P25/24 ,  A61P15/08

摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.