公开(公告)号：US10457674B2

公开(公告)日：2019-10-29

申请号：US16073355

申请日：2017-02-10

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Niall Andrew Anderson ,  Nicholas Paul Barton ,  Sebastien Andre Campos ,  Edward Paul Cannons ,  Anthony William James Cooper ,  Kenneth David Down ,  Kevin James Doyle ,  Julie Nicole Hamblin ,  Graham George Adam Inglis ,  Armelle Le Gall ,  Vipulkumar Kantibhai Patel ,  Simon Peace ,  Andrew Sharpe ,  Gemma Victoria White

IPC: C07D413/14 ,  C07D213/76 ,  A61P25/28 ,  A61P11/06 ,  A61P37/08 ,  A61P25/24 ,  A61P15/08

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.

公开(公告)号：US11649238B2

公开(公告)日：2023-05-16

申请号：US16961704

申请日：2019-01-15

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Nicholas Paul Barton ,  Sophie Marie Bertrand ,  Kenneth David Down ,  Matthew Gray

IPC: A61K31/519 ,  C07D487/04

CPC classification number: C07D487/04

Abstract: The invention relates to compounds of formula (I) which are inhibitors of kinase activity, pharmaceutical formulations containing the compounds and their uses in treating and preventing viral infections and disorders caused or exacerbated by the viral infection




wherein R1, R2, R3, R4a, R4b, R4c, R5, W, X, Y and Z are defined herein.

公开(公告)号：US11555040B2

公开(公告)日：2023-01-17

申请号：US16604605

申请日：2018-04-16

Applicant: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

Inventor： Andrew Baxter ,  Sophie Marie Bertrand ,  Matthew Campbell ,  Kenneth David Down ,  Curt Dale Haffner ,  Julie Nicole Hamblin ,  Zoe Alicia Henley ,  William Henry Miller ,  Eric Philippe Andre Talbot ,  Jonathan Andrew Taylor

IPC: C07D491/044

Abstract: The invention is directed to compounds of formula (I), and salts thereof. The compounds are inhibitors of kinase activity, in particular PI3-kinase activity.

公开(公告)号：US10793559B2

公开(公告)日：2020-10-06

申请号：US16572917

申请日：2019-09-17

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Niall Andrew Anderson ,  Nicholas Paul Barton ,  Sebastien Andre Campos ,  Edward Paul Cannons ,  Anthony William James Cooper ,  Kenneth David Down ,  Kevin James Doyle ,  Julie Nicole Hamblin ,  Graham George Adam Inglis ,  Armelle Le Gall ,  Vipulkumar Kantibhai Patel ,  Simon Peace ,  Andrew Sharpe ,  Gemma Victoria White

IPC: C07D413/14 ,  C07D213/76 ,  A61P25/28 ,  A61P11/06 ,  A61P37/08 ,  A61P25/24 ,  A61P15/08

Abstract: The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular PI3-kinase activity.