公开(公告)号：US20170152233A1

公开(公告)日：2017-06-01

申请号：US15431942

申请日：2017-02-14

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Michael Jonathan BURY ,  Linda N. CASILLAS ,  Adam K. CHARNLEY ,  Michael P. DEMARTINO ,  Xiaoyang DONG ,  Patrick M. EIDAM ,  Pamela A. HAILE ,  Robert W. MARQUIS, JR. ,  Joshi M. RAMANJULU ,  Joseph J. ROMANO ,  Ami Lakdawala SHAH ,  Robert R. SINGHAUS, JR. ,  Gren WANG

IPC: C07D239/94 ,  C07D403/12 ,  C07D417/14 ,  C07D417/12

CPC classification number: C07D239/94 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US20240228503A1

公开(公告)日：2024-07-11

申请号：US18586620

申请日：2024-02-26

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Adam K. CHARNLEY ,  Janos BOTYANSZKI ,  Xiaoyang DONG ,  Philip Gareth HUMPHREYS ,  Bryan Wayne KING ,  Kimberly Katherine MARCUS ,  Joseph PERO ,  Alexander Joseph REIF ,  Daohua ZHANG ,  Attiq RAHMAN(Deceased) ,  Kenneth Allen NEWLANDER ,  Kenneth WIGGALL ,  Joshi RAMANJULU

IPC: C07D487/04 ,  C07D403/14 ,  C07D471/04 ,  C07D471/14 ,  C07F9/6561

CPC classification number: C07D487/04 ,  C07D403/14 ,  C07D471/04 ,  C07D471/14 ,  C07F9/6561

Abstract: The present invention relates to compounds, compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.

公开(公告)号：US20180258056A1

公开(公告)日：2018-09-13

申请号：US15978377

申请日：2018-05-14

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Adam K. CHARNLEY ,  Xiaoyang DONG

IPC: C07D239/94 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D403/12

CPC classification number: C07D239/94 ,  C07D403/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

Abstract: Disclosed are compounds having the formula: wherein R1, R2, R3, and Z are as defined herein, and methods of making and using the same.

公开(公告)号：US20250092053A1

公开(公告)日：2025-03-20

申请号：US18966276

申请日：2024-12-03

Applicant: GlaxoSmithKline Intellectual Property Development Limited

Inventor： Adam K. CHARNLEY ,  Janos Botyanszki ,  Xiaoyang Dong ,  Philip Gareth Humphreys ,  Bryan Wayne King ,  Kimberly Katherine Marcus ,  Joseph Pero ,  Alexander Joseph Reif ,  Daohua Zhang ,  Attiq Rahman ,  Kenneth Allen Newlander ,  Kenneth Wiggall ,  Joshi Ramanjulu

IPC: C07D487/04 ,  C07D403/14 ,  C07D471/04 ,  C07D471/14 ,  C07F9/6561

Abstract: The present invention relates to compounds of Formula (I), compositions containing them, and to their use in the treatment of various disorders, in particular autoimmune, autoinflammatory or immune-mediated conditions, such as systemic lupus erythematosus (SLE), cutaneous lupus erythematosus (CLE) and lupus nephritis.