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公开(公告)号：US20180222982A1
公开(公告)日：2018-08-09
申请号：US15747873
申请日：2016-07-28
申请人： Glenn Dranoff , Gordon James Freeman , Arlene Helen Sharpe , Walter A. Blattler , Jennifer Marie Mataraza , Catherine Anne Sabatos-Peyton , Hwai Wen Chang , Gerhard Johann Frey , Novartis AG , DANA-FARBER CANCER INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Glenn Dranoff , Gordon James Freeman , Arlene Helen Sharpe , Walter A. Blattler , Jennifer Marie Mataraza , Catherine Anne Sabatos-Peyton , Hwai Wen Chang , Gerhard Johann Frey
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395
CPC分类号： C07K16/2818 , A61K39/00 , A61K39/39541 , A61K2039/505 , A61P35/00 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： Combination therapies comprising antibody molecules that specifically bind to PD-1 disclosed. The combination therapies can be used to treat or prevent cancerous or infectious conditions and disorders.
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2.发明申请公开(公告)号：US20190000944A1
公开(公告)日：2019-01-03
申请号：US16065387
申请日：2016-12-21
申请人： Jennifer Brogdon , Hwai Wen Chang , Boris Engels , Gordon James Freeman , Gerhard Johann Frey , Jennifer Marie Mataraza , Reshma Singh , Arlene Helen Sharpe , Novartis AG , The Trustees of the University of Pennsylvania , DANA-FARBER CANCER INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： Jennifer Brogdon , Hwai Wen Chang , Boris Engels , Gordon James Freeman , Gerhard Johann Frey , Jennifer Marie Mataraza , Reshma Singh , Arlene Helen Sharpe
IPC分类号： A61K39/00 , A61K39/395 , A61P35/00 , A61K45/06
摘要： Provided are compositions for use in methods for treating diseases associated with expression of mesothelin comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to mesothelin in combination with a PD-L1 inhibitor.
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公开(公告)号：US20180207273A1
公开(公告)日：2018-07-26
申请号：US15747326
申请日：2016-07-28
申请人： Glenn Dranoff , Catherine Anne Sabatos-Peyton , Barbara Brannetti , Alan S. Harris , Thomas Huber , Thomas Pietzonka , Jennifer Marie Mataraza , Walter A. Blattler , Daniel J. Hicklin , Maximiliano Vasquez , Rosemarie H. DeKruyff , Dale T. Umetsu , Gordon James Freeman , Tiancen Hu , John A. Taraszka , Fangmin Xu , Novartis AG , DANA-FARBER CANCER INSTITUTE, INC. , Children's Medical Center Corporation
发明人： Glenn Dranoff , Catherine Anne Sabatos-Peyton , Barbara Brannetti , Alan S. Harris , Thomas Huber , Thomas Pietzonka , Jennifer Marie Mataraza , Walter A. Blattler , Daniel J. Hicklin , Maximiliano Vasquez , Rosemarie H. DeKruyff , Dale T. Umetsu , Gordon James Freeman , Tiancen Hu , John A. Taraszka , Fangmin Xu
IPC分类号： A61K39/395 , A61K45/06 , A61P35/00
CPC分类号： A61K39/39566 , A61K39/00 , A61K39/3955 , A61K45/06 , A61K2039/507 , A61P35/00 , C07K16/2803 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/94 , A61K2300/00
摘要： Combination therapies comprising antibody molecules that specifically bind to TIM-3 are disclosed. The combination therapies can be used to treat or prevent cancerous or infectious conditions and disorders.
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公开(公告)号：US11827704B2
公开(公告)日：2023-11-28
申请号：US16925980
申请日：2020-07-10
发明人： Gordon James Freeman , Arlene Helen Sharpe , Walter A. Blattler , Jennifer Marie Mataraza , Catherine Anne Sabatos-Peyton , Hwai Wen Chang , Gerhard Johann Frey
IPC分类号： G01N33/574 , C07K16/28 , G01N33/566 , G01N33/68 , A61K45/06 , C07K16/30
CPC分类号： C07K16/2818 , A61K45/06 , C07K16/2896 , C07K16/30 , G01N33/566 , G01N33/57484 , G01N33/6854 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N2333/70596 , Y02A50/30
摘要： Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.
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公开(公告)号：US20230000964A1
公开(公告)日：2023-01-05
申请号：US17811606
申请日：2022-07-11
申请人： Novartis AG , The Trustees of the University of Pennsylvania , Dana-Farber Cancer Institute, Inc. , President and Fellows of Harvard College
发明人： Jennifer Brogdon , Hwai Wen Chang , Boris Engels , Gordon James Freeman , Gerhard Johann Frey , Jennifer Marie Mataraza , Reshma Singh , Arlene Helen Sharpe
IPC分类号： A61K39/00 , A61P35/00 , A61K39/395 , A61K45/06
摘要： Provided are compositions and methods for treating diseases associated with expression of mesothelin comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to mesothelin in combination with a PD-L1 inhibitor.
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公开(公告)号：US10851165B2
公开(公告)日：2020-12-01
申请号：US15900153
申请日：2018-02-20
发明人： Gordon James Freeman , Arlene Helen Sharpe , Gerhard Johann Frey , Hwai Wen Chang , Jennifer Marie Mataraza , Glenn Dranoff
IPC分类号： A61K39/395 , C07K16/28 , A61K45/06 , A61N5/10 , C07K16/30 , G01N33/574 , A61K39/00
摘要： Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.
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公开(公告)号：US09683048B2
公开(公告)日：2017-06-20
申请号：US14604415
申请日：2015-01-23
发明人： Gordon James Freeman , Arlene Helen Sharpe , Walter A. Blattler , Jennifer Marie Mataraza , Catherine Anne Sabatos-Peyton , Hwai Wen Chang , Gerhard Johann Frey
IPC分类号： A61K39/395 , C07K16/28 , G01N33/574 , G01N33/566 , G01N33/68 , A61K45/06
CPC分类号： C07K16/2818 , A61K39/3955 , A61K45/06 , C07K16/2896 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N33/566 , G01N33/57484 , G01N33/6854 , G01N2333/70596 , Y02A50/58
摘要： Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.
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公开(公告)号：US20240343808A1
公开(公告)日：2024-10-17
申请号：US18392954
申请日：2023-12-21
发明人： Gordon James Freeman , Arlene Helen Sharpe , Gerhard Johann Frey , Hwai Wen Chang , Jennifer Marie Mataraza , Glenn Dranoff
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395 , A61K45/06 , A61N5/10 , C07K16/30 , G01N33/574
CPC分类号： C07K16/2827 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61N5/10 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K16/3069 , G01N33/57492 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N2333/70532
摘要： Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.
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公开(公告)号：US20210284737A1
公开(公告)日：2021-09-16
申请号：US17078929
申请日：2020-10-23
发明人： Gordon James Freeman , Arlene Helen Sharpe , Gerhard Johann Frey , Hwai Wen Chang , Jennifer Marie Mataraza , Glenn Dranoff
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , A61N5/10 , C07K16/30 , G01N33/574
摘要： Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.
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公开(公告)号：US20150210769A1
公开(公告)日：2015-07-30
申请号：US14604415
申请日：2015-01-23
发明人： Gordon James Freeman , Arlene Helen Sharpe , Walter A. Blattler , Jennifer Marie Mataraza , Catherine Anne Sabatos-Peyton , Hwai Wen Chang , Gerhard Johann Frey
IPC分类号： C07K16/28 , G01N33/574 , A61K39/395
CPC分类号： C07K16/2818 , A61K39/3955 , A61K45/06 , C07K16/2896 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N33/566 , G01N33/57484 , G01N33/6854 , G01N2333/70596 , Y02A50/58
摘要： Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.
摘要翻译： 公开了特异性结合PD-1的抗体分子。 抗PD-1抗体分子可用于治疗，预防和/或诊断癌性或感染性疾病和病症。
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