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公开(公告)号:US20110142804A1
公开(公告)日:2011-06-16
申请号:US12954829
申请日:2010-11-26
申请人: Glenn Gaudette , Matthew D. Phaneuf , Syed Ali , Brian Almeida , Helena Alfonzo , Katie Flynn
发明人: Glenn Gaudette , Matthew D. Phaneuf , Syed Ali , Brian Almeida , Helena Alfonzo , Katie Flynn
CPC分类号: C12N11/08 , A61L27/18 , A61L27/3834 , A61L27/56 , A61L2400/12 , C12N5/0068 , C12N2533/30 , C08L75/04
摘要: The invention is directed to a device and method to prevent migration of Human Mesenchymal Stem Cells (hMSCs) from a delivery site while allowing communication between the stem cells and native cardiomyocytes. The device is characterized by scaffold pore size, fiber diameter and biomaterial selection. The invention includes a two part polyurethane scaffold that prevents migration of stem cells, allows gap junction formation through pores and is packaged for minimally invasive delivery.
摘要翻译: 本发明涉及一种阻止人间充质干细胞(hMSCs)从递送部位迁移的装置和方法,同时允许干细胞和天然心肌细胞之间的通信。 该装置的特征在于支架孔径,纤维直径和生物材料选择。 本发明包括防止干细胞迁移的两部分聚氨酯支架,允许通过孔形成间隙连接并被包装以进行微创递送。
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公开(公告)号:US08691543B2
公开(公告)日:2014-04-08
申请号:US12954829
申请日:2010-11-26
申请人: Glenn Gaudette , Matthew D. Phaneuf , Syed Ali , Brian Almeida , Helena Alfonzo , Katie Flynn
发明人: Glenn Gaudette , Matthew D. Phaneuf , Syed Ali , Brian Almeida , Helena Alfonzo , Katie Flynn
CPC分类号: C12N11/08 , A61L27/18 , A61L27/3834 , A61L27/56 , A61L2400/12 , C12N5/0068 , C12N2533/30 , C08L75/04
摘要: The invention is directed to a device and method to prevent migration of Human Mesenchymal Stem Cells (hMSCs) from a delivery site while allowing communication between the stem cells and native cardiomyocytes. The device is characterized by scaffold pore size, fiber diameter and biomaterial selection. The invention includes a two part polyurethane scaffold that prevents migration of stem cells, allows gap junction formation through pores and is packaged for minimally invasive delivery.
摘要翻译: 本发明涉及一种阻止人间充质干细胞(hMSCs)从递送部位迁移的装置和方法,同时允许干细胞和天然心肌细胞之间的通信。 该装置的特征在于支架孔径,纤维直径和生物材料选择。 本发明包括防止干细胞迁移的两部分聚氨酯支架,允许通过孔形成间隙连接并被包装以进行微创递送。
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