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    ELECTROSPINNING PROCESS FOR MAKING A TEXTILE SUITABLE FOR USE AS A MEDICAL ARTICLE
    3.
    发明申请
    ELECTROSPINNING PROCESS FOR MAKING A TEXTILE SUITABLE FOR USE AS A MEDICAL ARTICLE 有权
    用于制造适用于医疗用品的纺织品的电纺工艺

    公开(公告)号：US20140054828A9

    公开(公告)日：2014-02-27

    申请号：US13303319

    申请日：2011-11-23

    申请人： Matthew D. Phaneuf ,  Philip J. Brown ,  Martin J. Bide

    发明人： Matthew D. Phaneuf ,  Philip J. Brown ,  Martin J. Bide

    IPC分类号： B29C47/00

    CPC分类号： D01F6/62 ,  A61K9/0092 ,  A61K9/70 ,  B29C47/0004 ,  B29C47/0014 ,  D01D1/02 ,  D01D5/0038 ,  D04H1/435 ,  D04H1/728 ,  D04H3/011 ,  D04H3/02 ,  D04H3/16

    摘要： The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.

    摘要翻译： 本发明是使用独特的静电纺丝灌注方法制造的生物活性纳米纤维材料构造物。 一个实施方案提供了一种纳米纤维生物复合材料，其由（i）不可生物降解的耐久合成聚合物制备的液体混合物形成为离散纺织织物; （ii）生物活性剂; 和（iii）液体有机载体。 这些生物活性剂是在变得非永久地结合到形成的纺织材料之前和之后保持其公认的生物活性的化学化合物; 并且随着从周围环境中吸收水分而随后从织物中释放出离散的自由移动剂。

    NANOFIBROUS MATERIALS AS DRUG, PROTEIN, OR GENETIC RELEASE VEHICLES
    4.
    发明申请
    NANOFIBROUS MATERIALS AS DRUG, PROTEIN, OR GENETIC RELEASE VEHICLES 有权
    作为药物，蛋白质或遗传性载体的纳米材料

    公开(公告)号：US20120068384A1

    公开(公告)日：2012-03-22

    申请号：US13303319

    申请日：2011-11-23

    申请人： Matthew D. Phaneuf ,  Philip J. Brown ,  Martin J. Bide

    发明人： Matthew D. Phaneuf ,  Philip J. Brown ,  Martin J. Bide

    IPC分类号： B29C47/00

    CPC分类号： D01F6/62 ,  A61K9/0092 ,  A61K9/70 ,  B29C47/0004 ,  B29C47/0014 ,  D01D1/02 ,  D01D5/0038 ,  D04H1/435 ,  D04H1/728 ,  D04H3/011 ,  D04H3/02 ,  D04H3/16

    摘要： The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.

    摘要翻译： 本发明是使用独特的静电纺丝灌注方法制造的生物活性纳米纤维材料构造物。 一个实施方案提供了一种纳米纤维生物复合材料，其由（i）不可生物降解的耐久合成聚合物制备的液体混合物形成为离散纺织织物; （ii）生物活性剂; 和（iii）液体有机载体。 这些生物活性剂是在变得非永久地结合到形成的纺织材料之前和之后保持其公认的生物活性的化学化合物; 并且随着从周围环境中吸收水分而随后从织物中释放出离散的自由移动剂。

    Electrospinning process for making a textile suitable for use as a medical article
    7.
    发明授权
    Electrospinning process for making a textile suitable for use as a medical article 有权
    用于制造适合用作医疗制品的纺织品的静电纺丝方法

    公开(公告)号：US08771582B2

    公开(公告)日：2014-07-08

    申请号：US13303319

    申请日：2011-11-23

    申请人： Matthew D. Phaneuf ,  Philip J. Brown ,  Martin J. Bide

    发明人： Matthew D. Phaneuf ,  Philip J. Brown ,  Martin J. Bide

    IPC分类号： D04H3/02 ,  D06M10/00 ,  H05B6/00

    CPC分类号： D01F6/62 ,  A61K9/0092 ,  A61K9/70 ,  B29C47/0004 ,  B29C47/0014 ,  D01D1/02 ,  D01D5/0038 ,  D04H1/435 ,  D04H1/728 ,  D04H3/011 ,  D04H3/02 ,  D04H3/16

    摘要： The present invention is a bioactive, nanofibrous material construct which is manufactured using a unique electrospinning perfusion methodology. One embodiment provides a nanofibrous biocomposite material formed as a discrete textile fabric from a prepared liquid admixture of (i) a non-biodegradable durable synthetic polymer; (ii) a biologically active agent; and (iii) a liquid organic carrier. These biologically-active agents are chemical compounds which retain their recognized biological activity both before and after becoming non-permanently bound to the formed textile material; and will become subsequently released in-situ as discrete freely mobile agents from the fabric upon uptake of water from the ambient environment.

    摘要翻译： 本发明是使用独特的静电纺丝灌注方法制造的生物活性纳米纤维材料构造物。 一个实施方案提供了一种纳米纤维生物复合材料，其由（i）不可生物降解的耐久合成聚合物制备的液体混合物形成为离散纺织织物; （ii）生物活性剂; 和（iii）液体有机载体。 这些生物活性剂是在成为非永久性结合到形成的纺织材料之前和之后保持其公认的生物活性的化学化合物; 并且随着从周围环境中吸收水分而随后从织物中释放出离散的自由移动剂。

    Nanofibrous biocomposite prosthetic vascular graft
    8.
    发明授权
    Nanofibrous biocomposite prosthetic vascular graft 有权
    纳米纤维生物复合假体血管移植

    公开(公告)号：US07413575B2

    公开(公告)日：2008-08-19

    申请号：US11211935

    申请日：2005-08-25

    申请人： Matthew D. Phaneuf ,  Philip J. Brown ,  Martin J. Bide

    发明人： Matthew D. Phaneuf ,  Philip J. Brown ,  Martin J. Bide

    IPC分类号： A61F2/06 ,  B29C47/00 ,  H05B7/00

    CPC分类号： A61F2/06

    摘要： The present invention provides a bioactive, small-diameter (typically less than 6 mm in internal diameter) vascular graft prosthesis, and is a textile conduit preferably manufactured using a novel electrospinning perfusion methodology. One preferred embodiment is a nanofibrous biocomposite textile conduit which comprises a prepared liquid admixture of polyester (Dacron), a biodurable implantable synthetic polymer, and Type IV collagen, an extracellular matrix protein. This prepared admixture and blending of diverse fibrous matter is utilized in a novel electrospinning perfusion process to form a small-diameter (less than 6 mm) fabricated textile conduit, a discrete article of manufacture, which then serves as an antecedent tangible workpiece for a subsequently-made prosthetic vascular graft construct.

    摘要翻译： 本发明提供血管移植假体的生物活性的小直径（通常小于6mm的内径），并且是优选使用新的静电纺丝灌注方法制造的纺织导管。 一个优选的实施方案是纳米纤维生物复合纺织物导管，其包含制备的聚酯（Dacron）的液体混合物，可生物量可植入的合成聚合物和IV型胶原，细胞外基质蛋白。 这种制备的各种纤维物质的混合物和混合物被用于新的静电纺丝灌注工艺中以形成小直径（小于6mm）的制造的纺织品管道，其是随后用作先前的有形工件 人造血管移植物构造。