公开(公告)号：US09896470B2

公开(公告)日：2018-02-20

申请号：US14407256

申请日：2013-06-14

Applicant: Glycom A/S

Inventor： Andreas Schroven ,  Gyula Dekany ,  Peter Erdmann ,  Andrea Schwarz

IPC: C07H1/06 ,  C07H3/06 ,  A61K31/702 ,  A23L29/30 ,  A23L33/00 ,  A23L33/10

CPC classification number: C07H1/06 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A61K31/702 ,  C07H3/06 ,  A23V2200/30 ,  A23V2200/3204 ,  A23V2250/28

Abstract: The present application discloses a method for enhancing the stability of a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend when stored for extended periods at temperatures above 25° C. by spray-drying an aqueous solution of the HMO or HMO precursor to remove at least 90% of the water and providing a HMO or a HMO precursor or a HMO blend with a specific glass transition temperature. Also disclosed is a method for removing organic solvent residues from a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend by spray drying. Also disclosed is a method of enhancing the bioavailability of a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend by spray drying.

公开(公告)号：US20150183814A1

公开(公告)日：2015-07-02

申请号：US14407256

申请日：2013-06-14

Applicant: Glycom A/S

Inventor： Andreas Schroven ,  Gyula Dekany ,  Peter Erdmann ,  Andrea Schwarz

IPC: C07H1/06 ,  A23L1/30 ,  A23L1/09 ,  C07H3/06

CPC classification number: C07H1/06 ,  A23L5/00 ,  A23L29/30 ,  A23L33/10 ,  A23L33/125 ,  A23L33/40 ,  A23V2002/00 ,  A23V2200/00 ,  A61K31/702 ,  C07H3/06 ,  A23V2200/30 ,  A23V2200/3204 ,  A23V2250/28

Abstract: The present application discloses a method for enhancing the stability of a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend when stored for extended periods at temperatures above 25° C. by spray-drying an aqueous solution of the HMO or HMO precursor to remove at least 90% of the water and providing a HMO or a HMO precursor or a HMO blend with a specific glass transition temperature. Also disclosed is a method for removing organic solvent residues from a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend by spray drying. Also disclosed is a method of enhancing the bioavailability of a human milk oligosaccharide (HMO) or a HMO precursor or a HMO blend by spray drying.

Abstract translation: 本申请公开了一种通过喷雾干燥HMO或HMO的水溶液来在高于25℃的温度下长时间储存​​时增强人乳寡糖（HMO）或HMO前体或HMO共混物的稳定性的方法 去除至少90％的水并提供具有特定玻璃化转变温度的HMO或HMO前体或HMO共混物的前体。 还公开了通过喷雾干燥从人乳寡糖（HMO）或HMO前体或HMO共混物中除去有机溶剂残留物的方法。 还公开了通过喷雾干燥增强人乳寡糖（HMO）或HMO前体或HMO共混物的生物利用度的方法。