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    Compositions and methods for modulating NH2-terminal Jun Kinase activity
    1.
    发明授权
    Compositions and methods for modulating NH2-terminal Jun Kinase activity 失效
    调节NH2末端Jun激酶活性的组成和方法

    公开(公告)号：US07232897B2

    公开(公告)日：2007-06-19

    申请号：US10475505

    申请日：2002-04-24

    申请人： Gokhan S. Hotamisligil ,  Michael Karin ,  Lufen Chang

    发明人： Gokhan S. Hotamisligil ,  Michael Karin ,  Lufen Chang

    IPC分类号： C07H17/08 ,  A61K31/00

    CPC分类号： A61K31/675

    摘要： Disclosed herein are compositions and methods used to modulate a NH2-terminal Jun Kinase activity. These compositions and methods can be employed to regulate metabolic disorders associated with, for example, insulin such as diabetes. The reduction in NH2-terminal Jun Kinase activity can lead to the reduction in weight and improve insulin sensitivity.

    摘要翻译： 本文公开了用于调节NH 2 - 末端Jun激酶活性的组合物和方法。 这些组合物和方法可用于调节与诸如糖尿病之类的胰岛素相关的代谢紊乱。 NH 2 - 末端Jun激酶活性的降低可导致重量减轻并提高胰岛素敏感性。

    Inhibition of jun kinase
    2.
    发明申请
    Inhibition of jun kinase 失效
    抑制jun激酶

    公开(公告)号：US20050261247A1

    公开(公告)日：2005-11-24

    申请号：US10475505

    申请日：2002-04-24

    申请人： Gokhan Hotamisligil ,  Michael Karin ,  Lufen Chang

    发明人： Gokhan Hotamisligil ,  Michael Karin ,  Lufen Chang

    IPC分类号： A61K31/675

    CPC分类号： A61K31/675

    摘要： Disclosed herein are compositions and methods used to modulate a NH2-terminal Jun Kinase activity. These compositions and methods can be employed to regulate metabolic disorders associated with, for example, insulin such as diabetes. The reduction in NH2-terminal Jun Kinase activity can lead to the reduction in weight and improve insulin sensitivity.

    摘要翻译： 本文公开了用于调节NH 2 - 末端Jun激酶活性的组合物和方法。 这些组合物和方法可用于调节与诸如糖尿病之类的胰岛素相关的代谢紊乱。 NH 2 - 末端Jun激酶活性的降低可导致重量减轻并提高胰岛素敏感性。

    Inhibition of Jun Kinase
    3.
    发明申请
    Inhibition of Jun Kinase 审中-公开
    抑制Jun激酶

    公开(公告)号：US20070207137A1

    公开(公告)日：2007-09-06

    申请号：US11799397

    申请日：2007-05-01

    申请人： Gokhan Hotamisligil ,  Michael Karin ,  Lufen Chang

    发明人： Gokhan Hotamisligil ,  Michael Karin ,  Lufen Chang

    IPC分类号： A61K38/53

    CPC分类号： A61K31/675

    摘要： A method of treating a metabolic disorder associated with insulin resistance by administering to a mammal an inhibitor of a NH2-terminal Jun Kinase (JNK), e.g., a compound or peptide which inhibits JNK1 expression or enzymatic activity.

    摘要翻译： 通过对哺乳动物施用抑制JNK1表达或酶活性的化合物或肽的抑制剂（JNK），通过向哺乳动物施用与胰岛素抵抗相关的代谢障碍的方法。

    Methods for identifying and using IKK inhibitors
    7.
    发明授权
    Methods for identifying and using IKK inhibitors 有权

    公开(公告)号：US07053119B2

    公开(公告)日：2006-05-30

    申请号：US10376470

    申请日：2003-02-28

    申请人： Michael Karin ,  Pankaj Kapahi

    发明人： Michael Karin ,  Pankaj Kapahi

    IPC分类号： A61K31/215 ,  A61K31/12 ,  A61K31/035

    CPC分类号： A61K31/557 ,  A61K31/00 ,  A61K31/5575 ,  C12Q1/485 ,  G01N2500/04

    摘要： The present invention provides methods and compositions for inhibiting IKK, as well as methods and compositions for identifying compounds with activity as inhibitors of IKK, and methods and compositions for the treatment of diseases and/or conditions wherein IKK is implicated and inhibition of its activity is desired. In addition, the present invention provides methods and compositions for the improving the therapeutic activity of COX2 inhibitors, comprising administering the COX2 to a subject in combination with a compound that inhibits IKK activity. The present invention further provides compositions that comprise compounds that inhibit IKK and COX2.

    Mutations in IKK&ggr;
    8.
    发明授权
    Mutations in IKK&ggr; 失效
    IKKgamma中的突变

    公开(公告)号：US06689564B2

    公开(公告)日：2004-02-10

    申请号：US09882507

    申请日：2001-06-15

    申请人： Konstantinos Makris ,  Michael Karin

    发明人： Konstantinos Makris ,  Michael Karin

    IPC分类号： C12Q168

    CPC分类号： A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0306 ,  A01K2267/0368 ,  C12N9/12 ,  C12N15/8509

    摘要： The present invention relates to compositions and methods involving IKK&ggr; mutants. In particular, the present invention provides methods and compositions, including transgenic animals, suitable for use in determining means to treat, control, and/or prevent incontinentia pigmenti (IP). The present invention also provides methods to detect the presence of mutations in the IKK&ggr; gene and protein.

    摘要翻译： 本发明涉及涉及IKKgamma突变体的组合物和方法。 特别地，本发明提供了包括转基因动物的方法和组合物，其适合用于确定治疗，控制和/或预防失色素（IP）的手段。 本发明还提供了检测IKKgamma基因和蛋白质中突变的存在的方法。

    Methods for identifying and using IKK inhibitors
    9.
    发明授权
    Methods for identifying and using IKK inhibitors 失效

    公开(公告)号：US06649654B1

    公开(公告)日：2003-11-18

    申请号：US09721380

    申请日：2000-11-22

    申请人： Michael Karin ,  Pankaj Kapahi

    发明人： Michael Karin ,  Pankaj Kapahi

    IPC分类号： A01N3708

    CPC分类号： A61K31/557 ,  A61K31/00 ,  A61K31/5575 ,  C12Q1/485 ,  G01N2500/04

    摘要： The present invention provides methods and compositions for inhibiting IKK, as well as methods and compositions for identifying compounds with activity as inhibitors of IKK, and methods and compositions for the treatment of diseases and/or conditions wherein IKK is implicated and inhibition of its activity is desired. In addition, the present invention provides methods and compositions for the improving the therapeutic activity of COX2 inhibitors, comprising administering the COX2 to a subject in combination with a compound that inhibits IKK activity. The present invention further provides compositions that comprise compounds that inhibit IKK and COX2.

    IKB kinase and methods of using same
    10.
    发明授权
    IKB kinase and methods of using same 失效
    IKB激酶及其使用方法

    公开(公告)号：US06268194B1

    公开(公告)日：2001-07-31

    申请号：US08810131

    申请日：1997-02-25

    申请人： Michael Karin ,  Joseph A. DiDonato ,  David M. Rothwarf ,  Makio Hayakawa ,  Ebrahim Zandi

    发明人： Michael Karin ,  Joseph A. DiDonato ,  David M. Rothwarf ,  Makio Hayakawa ,  Ebrahim Zandi

    IPC分类号： C12N912

    CPC分类号： G01N33/6842 ,  A61K38/00 ,  C07K16/40 ,  C12N9/1205 ,  C12Q1/48 ,  C12Y207/1101 ,  G01N33/68 ,  G01N2333/9121

    摘要： The present invention provides a substantially purified nucleic acid molecule encoding a serine protein kinase (I&kgr;B kinase) that phosphorylates a protein (I&kgr;B) that inhibits the activity of the NF-&kgr;B transcription factor, vectors comprising such a nucleic acid molecule and host cells containing such vectors. In addition, the invention provides nucleotide sequences that can bind to a nucleic acid molecule of the invention, such nucleotide sequences being useful as probes or as antisense molecules. The invention also provides a substantially purified I&kgr;B kinase, which is a polypeptide that can phosphorylate an I&kgr;B protein, and peptide portions of the I&kgr;B kinase. In addition, the invention provides anti-I&kgr;B kinase antibodies, which specifically bind to an I&kgr;B kinase, and I&kgr;B kinase-binding fragments of such antibodies. The invention further provides methods of substantially purifying an I&kgr;B kinase, methods of identifying an agent that can alter the association of an I&kgr;B kinase with a second protein, and methods of identifying proteins that can interact with an I&kgr;B kinase.

    摘要翻译： 本发明提供了编码丝氨酸蛋白激酶（IkappaB激酶）的基本上纯化的核酸分子，其磷酸化抑制NF-κB转录因子的活性的蛋白质（IkappaB），包含这种核酸分子的载体和含有这种核酸分子的宿主细胞 向量 此外，本发明提供可结合本发明的核酸分子的核苷酸序列，该核苷酸序列可用作探针或作为反义分子。 本发明还提供了基本上纯化的IkappaB激酶，其是能够磷酸化IkappaB蛋白的多肽和IkappaB激酶的肽部分。 此外，本发明提供了抗IkappaB激酶抗体，其特异性结合IkappaB激酶和这些抗体的IkappaB激酶结合片段。 本发明还提供了实质上纯化IkappaB激酶的方法，鉴定可以改变IkappaB激酶与第二种蛋白质的缔合的试剂的方法，以及鉴定可与IkappaB激酶相互作用的蛋白质的方法。