公开(公告)号：US10322215B2

公开(公告)日：2019-06-18

申请号：US13816299

申请日：2011-08-11

申请人： Goran Stojcevic ,  Gilles Arsenault ,  Elizabeth R. Gillies ,  Collin V. Bonduelle ,  Matthew J. McEachran

发明人： Goran Stojcevic ,  Gilles Arsenault ,  Elizabeth R. Gillies ,  Collin V. Bonduelle ,  Matthew J. McEachran

IPC分类号： A61L31/10 ,  A61L29/08 ,  A61L29/14 ,  B05D5/04 ,  B05D7/00 ,  C08C19/06 ,  C09D123/18 ,  C09D123/22 ,  C09D123/30 ,  C08F210/12

摘要： Functionalized copolymers of isoolefins and conjugated diolefins, methods of preparing the copolymers, and their use as compatibilizers are disclosed. The diolefin monomer units of the co-polymer are modified at the C—C double bond along the backbone of the copolymer to include an oxygen containing functional group such as epoxide, ester or alcohol. The functionalized copolymers improve the wettability of a non-hydrophilic surface towards hydrophilic polymer and allows for the formation of homogenous layers of the hydrophilic polymers. In particular, the spreading of a hydrophilic polymer on a non-hydrophilic substrate is facilitated by applying the co-polymers as an interfacial layer between the two incompatible materials. The resulting coated substrates exhibit resistance to protein adsorption and cell growth after grafting. The co-polymers are especially suited in the coating of biomedical devices where a high degree of uniformity of the coated surface is required.

公开(公告)号：US20140004252A1

公开(公告)日：2014-01-02

申请号：US13816299

申请日：2011-08-11

申请人： Goran Stojcevic ,  Gilles Arsenault ,  Elizabeth R. Gillies ,  Colin V. Bonduelle ,  Matthew J. McEachran

发明人： Goran Stojcevic ,  Gilles Arsenault ,  Elizabeth R. Gillies ,  Colin V. Bonduelle ,  Matthew J. McEachran

IPC分类号： A61L31/10

CPC分类号： A61L31/10 ,  A61L29/085 ,  A61L29/14 ,  A61L2420/08 ,  B05D5/04 ,  B05D7/54 ,  B05D2201/02 ,  B05D2530/00 ,  C08C19/06 ,  C08F210/12 ,  C09D123/18 ,  C09D123/22 ,  C09D123/30 ,  C08F236/08

摘要： Functionalized copolymers of isoolefins and conjugated diolefins, methods of preparing said copolymers, and their use as compatibilizers are disclosed. The diolefin monomer units of the co-polymer are modified at the C—C double bond along the backbone of the copolymer to include an oxygen containing functional group such as epoxide, ester or alcohol. The functionalized copolymers improve the wettabilty of a non-hydrophilic surface towards hydrophilic polymer and allows for the formation of homogenous layers of the hydrophilic polymers. In particular, the spreading of a hydrophilic polymer on a non-hydrophilic substrate is facilitated by applying the co-polymers as an interfacial layer between the two incompatible materials. The resulting coated substrates exhibit resistance to protein adsorption and cell growth after grafting. The co-polymers are especially suited in the coating of biomedical devices where a high degree of uniformity of the coated surface is required.

摘要翻译： 公开了异烯烃和共轭二烯烃的官能化共聚物，制备所述共聚物的方法及其作为增容剂的用途。 共聚物的二烯烃单体单元沿着共聚物的主链在C-C双键上被修饰，以包括含氧官能团如环氧化物，酯或醇。 官能化共聚物使亲水性聚合物的非亲水性表面的润湿性提高，并允许形成亲水性聚合物的均匀层。 特别地，通过将​​共聚物作为两种不相容材料之间的界面层来促进亲水性聚合物在非亲水性基材上的铺展。 所得涂覆的基质在移植后显示出抗蛋白质吸附和细胞生长。 共聚物特别适用于需要涂层表面高度均匀性的生物医学装置的涂层。

公开(公告)号：US09487613B2

公开(公告)日：2016-11-08

申请号：US13816549

申请日：2011-08-11

申请人： Goran Stojcevic ,  Lorenzo P. Ferrari ,  Dana K. Adkinson ,  Elizabeth R. Gillies ,  Collin V. Bonduelle ,  Solmaz Karamdoust

发明人： Goran Stojcevic ,  Lorenzo P. Ferrari ,  Dana K. Adkinson ,  Elizabeth R. Gillies ,  Collin V. Bonduelle ,  Solmaz Karamdoust

IPC分类号： C08F279/02 ,  C08F8/00 ,  C08F8/08 ,  C08F8/14 ,  C08G81/02 ,  C08F210/12 ,  C08C19/30 ,  C08J3/03 ,  C08F236/08

CPC分类号： C08F279/02 ,  C08C19/30 ,  C08F8/00 ,  C08F8/08 ,  C08F8/14 ,  C08F210/12 ,  C08F236/08 ,  C08G81/025 ,  C08J3/03 ,  C08J2323/22 ,  C08J2323/26

摘要： The present invention relates to novel graft copolymers of functionalized poly(isoolefin-co-conjugated diolefin, and a process of preparing such graft copolymers. The present invention also relates to a method of preparing functionalized copolymers of isoolefins and conjugated diolefins.

摘要翻译： 本发明涉及官能化聚（异烯烃共轭共轭二烯烃）和制备这种接枝共聚物的方法的新型接枝共聚物，本发明还涉及制备异烯烃和共轭二烯烃官能化共聚物的方法。

公开(公告)号：US20130345367A1

公开(公告)日：2013-12-26

申请号：US13816549

申请日：2011-08-11

申请人： Goran Stojcevic ,  Lorenzo P. Ferrari ,  Dana K. Adkinson ,  Elizabeth R. Gillies ,  Collin V. Bonduelle ,  Solmaz Karamdoust

发明人： Goran Stojcevic ,  Lorenzo P. Ferrari ,  Dana K. Adkinson ,  Elizabeth R. Gillies ,  Collin V. Bonduelle ,  Solmaz Karamdoust

IPC分类号： C08F279/02

CPC分类号： C08F279/02 ,  C08C19/30 ,  C08F8/00 ,  C08F8/08 ,  C08F8/14 ,  C08F210/12 ,  C08F236/08 ,  C08G81/025 ,  C08J3/03 ,  C08J2323/22 ,  C08J2323/26

摘要： The present invention relates to novel graft copolymers of functionalized poly(isoolefin-co-conjugated diolefin, and a process of preparing such graft copolymers. The present invention also relates to a method of preparing functionalized copolymers of isoolefins and conjugated diolefins.

摘要翻译： 本发明涉及官能化聚（异烯烃共轭共轭二烯烃）和制备这种接枝共聚物的方法的新型接枝共聚物，本发明还涉及制备异烯烃和共轭二烯烃官能化共聚物的方法。

公开(公告)号：US20130261250A1

公开(公告)日：2013-10-03

申请号：US13640541

申请日：2011-04-08

申请人： Goran Stojcevic ,  Steven Teertstra ,  Lorenzo Ferrari ,  Kevin Kulbaba ,  Greg Davidson

发明人： Goran Stojcevic ,  Steven Teertstra ,  Lorenzo Ferrari ,  Kevin Kulbaba ,  Greg Davidson

IPC分类号： C08F212/08 ,  C08F236/10

CPC分类号： C08F212/08 ,  A61L31/10 ,  C08F236/10 ,  C08F257/02 ,  C08L25/10 ,  C08F210/10 ,  C08F236/08

摘要： The present invention relates to arborescent polymers comprising isoolefins and styrenic monomers, as well as processes for making same. In particular, the invention relates to highly branched block copolymers comprising an arborescent core with a high glass-transition temperature (Tg) and branches attached to the core terminated in polymer endblock segments with a low Tg. The copolymers of the invention desirably exhibit thermoplastic elastomeric properties and, in one embodiment, are desirably suited to biomedical applications.

摘要翻译： 本发明涉及包含异烯烃和苯乙烯类单体的芳族聚合物，以及其制备方法。 特别地，本发明涉及高支化嵌段共聚物，其包含具有高玻璃化转变温度（Tg）的支化核心，并且分支连接到端接在具有低Tg的聚合物末端嵌段段中的核心。 本发明的共聚物理想地显示出热塑性弹性体性质，并且在一个实施方案中期望地适合于生物医学应用。