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    Subcutaneous electric field distribution system and methods
    2.
    发明授权
    Subcutaneous electric field distribution system and methods 有权
    皮下电场分布系统及方法

    公开(公告)号：US08454591B2

    公开(公告)日：2013-06-04

    申请号：US13441782

    申请日：2012-04-06

    申请人： Greg Leyh ,  Jerzy Orkiszewski

    发明人： Greg Leyh ,  Jerzy Orkiszewski

    IPC分类号： A61M1/00

    CPC分类号： A61B18/14 ,  A61B2018/00291 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00738 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/124 ,  A61B2018/1467

    摘要： Apparatus and methods for dynamically controlling electric field distribution within tissue disposed at various depths beneath the skin at a target region of a patient's body by independently controlling the electric potential of each of a plurality of electrodes in relation to the electric potential of a ground pad. By controlling electric field distribution during a procedure, a target tissue at particular depths beneath the skin can be selectively heated relative to adjacent non-target tissue. At least one of the electrodes and the ground pad may comprise a spiral inductor comprising a substantially planar spiral of electrically conductive material.

    摘要翻译： 用于通过独立地控制多个电极中的每一个相对于接地焊盘的电位的电势来动态地控制设置在患者身体的目标区域的皮肤下方的各种深度处的组织内的电场分布的装置和方法。 通过控制手术期间的电场分布，可以相对于相邻的非目标组织选择性地加热皮肤下面特定深度的靶组织。 电极和接地焊盘中的至少一个可以包括螺旋电感器，其包括基本上平面的导电材料螺旋。

    Subcutaneous electric field distribution system and methods
    3.
    发明授权
    Subcutaneous electric field distribution system and methods 有权
    皮下电场分布系统及方法

    公开(公告)号：US08172835B2

    公开(公告)日：2012-05-08

    申请号：US12144948

    申请日：2008-06-24

    申请人： Greg Leyh ,  Jerzy Orkiszewski

    发明人： Greg Leyh ,  Jerzy Orkiszewski

    IPC分类号： A61B18/04

    CPC分类号： A61B18/14 ,  A61B2018/00291 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00738 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/124 ,  A61B2018/1467

    摘要： Apparatus and methods for dynamically controlling electric field distribution within tissue disposed at various depths beneath the skin at a target region of a patient's body by independently controlling the electric potential of each of a plurality of electrodes in relation to the electric potential of a ground pad. By controlling electric field distribution during a procedure, a target tissue at particular depths beneath the skin can be selectively heated relative to adjacent non-target tissue. At least one of the electrodes and the ground pad may comprise a spiral inductor comprising a substantially planar spiral of electrically conductive material.

    摘要翻译： 用于通过独立地控制多个电极中的每一个相对于接地焊盘的电位的电势来动态地控制设置在患者身体的目标区域的皮肤下方的各种深度处的组织内的电场分布的装置和方法。 通过控制手术期间的电场分布，可以相对于相邻的非目标组织选择性地加热皮肤下面特定深度的靶组织。 电极和接地焊盘中的至少一个可以包括螺旋电感器，其包括基本上平面的导电材料螺旋。

    SUBCUTANEOUS ELECTRIC FIELD DISTRIBUTION SYSTEM AND METHODS
    4.
    发明申请
    SUBCUTANEOUS ELECTRIC FIELD DISTRIBUTION SYSTEM AND METHODS 有权
    SUBCUTANEOUS电场分配系统和方法

    公开(公告)号：US20090318917A1

    公开(公告)日：2009-12-24

    申请号：US12144948

    申请日：2008-06-24

    申请人： GREG LEYH ,  Jerzy Orkiszewski

    发明人： GREG LEYH ,  Jerzy Orkiszewski

    IPC分类号： A61B18/14

    CPC分类号： A61B18/14 ,  A61B2018/00291 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00738 ,  A61B2018/00767 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/124 ,  A61B2018/1467

    摘要： Apparatus and methods for dynamically controlling electric field distribution within tissue disposed at various depths beneath the skin at a target region of a patient's body by independently controlling the electric potential of each of a plurality of electrodes in relation to the electric potential of a ground pad. By controlling electric field distribution during a procedure, a target tissue at particular depths beneath the skin can be selectively heated relative to adjacent non-target tissue. At least one of the electrodes and the ground pad may comprise a spiral inductor comprising a substantially planar spiral of electrically conductive material.

    摘要翻译： 用于通过独立地控制多个电极中的每一个相对于接地焊盘的电位的电势来动态地控制设置在患者身体的目标区域的皮肤下方的各种深度处的组织内的电场分布的装置和方法。 通过控制手术期间的电场分布，可以相对于相邻的非目标组织选择性地加热皮肤下面特定深度的靶组织。 电极和接地焊盘中的至少一个可以包括螺旋电感器，其包括基本上平面的导电材料螺旋。

    System for detecting, measuring and compensating for lateral movements of a target
    5.
    发明授权
    System for detecting, measuring and compensating for lateral movements of a target 失效

    公开(公告)号：US06702809B1

    公开(公告)日：2004-03-09

    申请号：US09172976

    申请日：1998-10-14

    申请人： Carl F. Knopp ,  Jerzy Orkiszewski ,  Jan Wysopal ,  Hanna J. Hoffman

    发明人： Carl F. Knopp ,  Jerzy Orkiszewski ,  Jan Wysopal ,  Hanna J. Hoffman

    IPC分类号： A61F9007

    CPC分类号： B23K26/04 ,  A61B3/113 ,  A61B2017/00694 ,  A61F9/008 ,  A61F9/00804 ,  A61F2009/0035 ,  A61F2009/00846 ,  A61F2009/00872 ,  B23K26/043 ,  B23K26/705

    摘要： A method, apparatus and system for a transverse tracker is described that can greatly improve the accuracy, speed, range, reliability, versatility, safety, and efficacy of interventions such as laser microsurgery, particularly ophthalmic surgery, and industrial micromachining. The instrument and system disclosed are applicable to those situations wherein the positioning accuracy of laser lesions is critical, and/or whenever precise operations on a target or series of targets subject to random movement during a procedure are to be effected. The present invention provides means for stabilizing the motion of targets in a plane perpendicular to the axial direction, thus allowing an imaging system, diagnostics illumination, and/or laser beam to maintain a lock on the target area, regardless of its movement. The invention also provides means for recording eye movements in real time and in which data can be stored and manipulated for the purpose of compensating for lateral target motion by either hardware or software means. Unique attributes provided in the tracking system include means for (1) sensing contrast in recognizable large scale boundaries such as the change between the cornea/sclera interface (limbus), thereby to determine the absolute location and orientation of these boundaries, all without having to resort to digital sampling techniques and (2) dual mode operation of an electronic control system compatible with all analog technologies, thereby substantially increasing the speed of operations over other, comparable digital method. The tracking system of the invention is at least comprised of illumination sources, imaging optics, a sensor such as a position-sensitive detector, a movable optical element such as a mirror, a two-dimensional logic board, and a dedicated microprocessor, including appropriate signal processing firmware and software. Additional optics can be incorporated to provide interface with other assemblies such as depth tracking, target viewing and/or laser surgery subsystems. The system of the invention affords considerable flexibility in selecting particular components such as the illuminators, detectors and servo devices, which, in turn, allows broad application of this system to tracking tasks in diverse medical surgical, diagnostic, and industrial settings.

    Electronically pulsed laser system
    6.
    发明授权
    Electronically pulsed laser system 失效
    电脉冲激光系统

    公开(公告)号：US6135995A

    公开(公告)日：2000-10-24

    申请号：US710577

    申请日：1996-09-19

    申请人： Michael Arnett ,  Robert J. Rorden ,  Gregory Dumond ,  Jerzy Orkiszewski ,  David Dewey ,  David Trost

    发明人： Michael Arnett ,  Robert J. Rorden ,  Gregory Dumond ,  Jerzy Orkiszewski ,  David Dewey ,  David Trost

    IPC分类号： A61B18/20 ,  B23K26/00 ,  B23K26/42 ,  A61N5/06

    CPC分类号： A61B18/20 ,  B23K26/0096 ,  A61B2018/00636

    摘要： Typically, a laser emits significant energy after a control signal is generated to disable the power supply. The inherent delay between generation of a control signal for shutting off a laser power supply and actual termination of an output beam pulse in response to the control signal, is compensated in the context that the control signal is generated automatically upon coincidence of measured output beam power with a preset threshold value. Power supplied to a laser is modulated to cause generation of a pulsed laser output beam. The cumulative energy of each output beam pulse is monitored and a feedback signal indicative of measured output beam pulse energy is supplied to the power supply. The feedback signal is compared with a user-selected threshold value, and a control signal is generated for terminating the output beam pulse (by terminating input power to the laser) when the measured output pulse energy reaches the threshold value. By generating the threshold signal to have a value representing a threshold output beam pulse energy that is lower than a desired output beam pulse energy, the threshold signal is generated in a manner which compensates for the inherent delay between generation of the control signal and the actual termination of the output beam pulse in response to the control signal. This prevents delivery of significant output beam energy in excess of a user-selected amount.

    摘要翻译： 通常，在产生控制信号以禁用电源之后，激光器发射显着的能量。 在响应于控制信号的用于关闭激光电源的控制信号的产生和输出光束脉冲的实际终止之间的固有延迟在上下文中得到补偿，所述上下文中控制信号在测量的输出光束功率一致时自动产生 具有预设的阈值。 对激光器供电的功率被调制以产生脉冲激光输出光束。 监视每个输出光束脉冲的累积能量，并将指示测量的输出光束脉冲能量的反馈信号提供给电源。 将反馈信号与用户选择的阈值进行比较，并且当测量的输出脉冲能量达到阈值时，生成用于终止输出光束脉冲（通过终止对激光器的输入功率）的控制信号。 通过产生阈值信号以具有表示低于期望的输出光束脉冲能量的阈值输出光束脉冲能量的值，该阈值信号以补偿控制信号的产生与实际的信号之间的固有延迟的方式产生 响应于控制信号终止输出光束脉冲。 这防止输出超过用户选择量的显着输出光束能量。

    Automated laser workstation for high precision surgical and industrial interventions
    7.
    发明授权
    Automated laser workstation for high precision surgical and industrial interventions 失效
    自动化激光工作站，用于高精度手术和工业干预

    公开(公告)号：US06099522A

    公开(公告)日：2000-08-08

    申请号：US523738

    申请日：1995-09-05

    申请人： Carl F. Knopp ,  William D. Fountain ,  Jerzy Orkiszewski ,  Michael Persiantsev ,  H. Alfred Sklar ,  Jan Wysopal

    发明人： Carl F. Knopp ,  William D. Fountain ,  Jerzy Orkiszewski ,  Michael Persiantsev ,  H. Alfred Sklar ,  Jan Wysopal

    IPC分类号： A61B17/00 ,  A61F9/00 ,  A61F9/008 ,  A61F9/01 ,  B23K26/00 ,  B23K26/04 ,  B23K26/42 ,  A61N5/02 ,  A61N5/06

    CPC分类号： B23K26/04 ,  A61F9/008 ,  A61F9/00804 ,  B23K26/0096 ,  A61B2017/00199 ,  A61B2017/00694 ,  A61B2017/00973 ,  A61F2009/0035 ,  A61F2009/00846 ,  A61F2009/00863 ,  A61F2009/00868 ,  A61F2009/0087 ,  A61F2009/00872 ,  A61F2009/00876 ,  A61F2009/00882 ,  A61F2009/00889 ,  A61F9/00802 ,  A61F9/00821 ,  A61F9/00825

    摘要： A method, apparatus and system for template-controlled, precision laser interventions is described that greatly improves the accuracy, speed, range, reliability, versatility, safety, and efficacy of interventions such as laser microsurgery, particularly ophthalmic surgery, and industrial micromachining. The instrument and system are applicable to those specialties wherein the positioning accuracy of laser lesions is critical, wherever accurate containment of the spatial extent of a laser lesion is desirable, and/or whenever precise operations on a target or series of targets subject to movement during the procedure are to be effected. The system thus comprises the following key elements: (1) a user interface, consisting of a video display, microprocessor and controls, (2) an imaging system, which may include a surgical video microscope with zoom capability, (3) an automated 3D target acquisition and tracking system that can follow the movements of the subject tissue, for example an eye, during the operation, thus allowing the surgeon/user to predetermine his firing patern based on an image which is automatically stabilized over time, (4) a laser, with which can be focused so that only the precise lesions described by the user interface are effected, (5) a diagnostic system, incorporating a mapping and topography means for measuring precise surface shapes prior to and subsequent to a procedure, said measurements to be executed on-line within time scales not limited to human response times, and (6) a fast reliable safety means, whereby the laser firing is interrupted automatically, should any conditions arise to warrant such interruption of the procedure.

    摘要翻译： 描述了用于模板控制的精密激光干预的方法，装置和系统，其大大提高了诸如激光显微外科手术，特别是眼科手术和工业微加工的干预的精度，速度，范围，可靠性，多功能性，安全性和有效性。 该仪器和系统适用于其中激光损伤的定位精度至关重要的那些专业，无论何时准确地控制激光损伤的空间范围是可取的，以及/或每当对目标或一系列目标进行精确的操作时， 该程序将被实施。 因此，该系统包括以下关键元件：（1）由视频显示器，微处理器和控制器组成的用户界面，（2）可以包括具有缩放能力的外科视频显微镜的成像系统，（3）自动3D 目标采集和跟踪系统，其可以在操作期间跟随主体组织（例如眼睛）的移动，从而允许外科医生/使用者基​​于随时间自动稳定的图像来预先确定他的射击部分，（4） 激光器，其可以被聚焦，使得仅实现由用户界面描述的精确病变，（5）诊断系统，其包括用于在程序之前和之后测量精确表面形状的映射和形貌装置，所述测量结果 在不限于人类反应时间的时间范围内在线执行，以及（6）快速可靠的安全手段，如果战争出现任何条件，激光射击自动中断 这样的中断程序。

    System for detecting, measuring and compensating for lateral movements of a target
    10.
    发明授权
    System for detecting, measuring and compensating for lateral movements of a target 失效
    用于检测，测量和补偿目标的横向运动的系统

    公开(公告)号：US5865832A

    公开(公告)日：1999-02-02

    申请号：US515152

    申请日：1995-08-15

    申请人： Carl F. Knopp ,  Jerzy Orkiszewski ,  Jan Wysopal ,  Hanna J. Hoffman

    发明人： Carl F. Knopp ,  Jerzy Orkiszewski ,  Jan Wysopal ,  Hanna J. Hoffman

    IPC分类号： A61F9/008 ,  A61F9/01 ,  B23K26/04 ,  A61N5/06

    CPC分类号： A61F9/008 ,  B23K26/04 ,  B23K26/043 ,  A61F2009/00846 ,  A61F2009/00872 ,  A61F2009/00897

    摘要： A method, apparatus and system for a transverse tracker is described that can greatly improve the accuracy, speed, range, reliability, versatility, safety, and efficacy of interventions such as laser microsurgery. The present invention provides means for stabilizing the motion of targets in a plane perpendicular to the axial direction, thus allowing an imaging system, diagnostics illumination, and/or laser beam to maintain a lock on the target area, regardless of its movement. Unique attributes provided in the tracking system include means for (1) sensing contrast in recognizable large scale boundaries such as the change between the cornea/sclera interface (limbus), thereby to determine the absolute location and orientation of these boundaries, all without having to resort to digital sampling techniques and (2) dual mode operation of an electronic control system compatible with all analog technologies, thereby substantially increasing the speed of operations over other, comparable digital method. The tracking system of the invention is at least comprised of illumination sources, imaging optics, a sensor, a movable optical element, a two-dimensional logic board, and a dedicated microprocessor, including appropriate signal processing firmware and software. Additional optics can provide interface with depth tracking, target viewing and/or laser surgery subsystems. The invention affords considerable flexibility in selecting illuminators, detectors and servo devices, which, allows broad application of this system to diverse medical surgical, diagnostic, and industrial settings.

    摘要翻译： 描述了用于横向跟踪器的方法，装置和系统，其可以大大提高诸如激光显微外科之类的干预的精度，速度，范围，可靠性，多功能性，安全性和有效性。 本发明提供了用于稳定目标在垂直于轴向方向的平面中的运动的装置，从而允许成像系统，诊断照明和/或激光束在目标区域上保持锁定，而不管其运动如何。 在跟踪系统中提供的独特属性包括用于（1）在可识别的大尺度边界中感测对比度的装置，例如角膜/巩膜界面（角膜缘）之间的变化，从而确定这些边界的绝对位置和取向，而不必 采用数字采样技术和（2）与所有模拟技术兼容的电子控制系统的双模式操作，从而大大提高了其他可比数字方式的操作速度。 本发明的跟踪系统至少包括照明源，成像光学器件，传感器，可移动光学元件，二维逻辑板和专用微处理器，包括适当的信号处理固件和软件。 附加光学器件可以提供与深度跟踪，目标观察和/或激光手术子系统的接口。 本发明在选择照明器，检测器和伺服装置方面具有相当大的灵活性，这允许该系统广泛应用于多种医疗手术，诊断和工业设置。