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公开(公告)号：US20050072675A1
公开(公告)日：2005-04-07
申请号：US10714047
申请日：2003-11-13
CPC分类号： B01D61/58 , B01D57/02 , B01D61/025 , B01D61/027 , B01D61/145 , B01D61/147 , B01D61/425 , C07K1/26
摘要： Method and appliance for carrying out membrane electrophoresis using microfiltration or ultrafiltration membranes, wherein the electroosmotic flow which develops in the membrane pores is reduced or offset by pressure superposition. The appliance for the membrane electrophoresis comprises at least an at least quadrupartite separation chamber (7), having at least one diluate space (16) and one concentrate space (17) and also a cathode space (18) and an anode space (21) having electrodes as anode (19) and cathode (20), with the individual spaces (16, 17, 18, 21) being separated from each other by ultrafiltration or microfiltration membranes (14, 15); feed lines (22) and discharge lines (23) for the diluate, feed lines (24) and discharge lines (25) for the concentrate, optionally feed lines (26) and discharge-lines (27) for the electrode rinsing solution, and also a device (8; 10) or (9; 11) for pressure regulation by means of which a pressure difference, in particular of at least 3 kPa, can be generated between the diluate space (16) and the concentrate space (17).
摘要翻译： 使用微滤或超滤膜进行膜电泳的方法和装置，其中在膜孔中形成的电渗流减少或通过压力叠加抵消。 用于膜电泳的器具至少包括至少四分之一的分离室（7），其具有至少一个稀释空间（16）和一个浓缩空间（17）以及阴极空间（18）和阳极空间（21） 具有作为阳极（19）和阴极（20）的电极，其中各个空间（16,17,18,21）通过超滤或微滤膜（14,15）彼此分离; 用于浓缩物的稀释供料管线（24）和排出管线（25）的进料管线（22）和排出管线（23），用于电极漂洗溶液的任选的进料管线（26）和排出管线（27） 还有用于压力调节的装置（8; 10）或（9; 11），通过该装置可以在稀释空间（16）和浓缩空间（17）之间产生特别是至少3kPa的压力差， 。
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公开(公告)号：US07449093B2
公开(公告)日：2008-11-11
申请号：US10714047
申请日：2003-11-13
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： B01D61/58 , B01D57/02 , B01D61/025 , B01D61/027 , B01D61/145 , B01D61/147 , B01D61/425 , C07K1/26
摘要： Method and appliance for carrying out membrane electrophoresis using microfiltration or ultrafiltration membranes, wherein the electroosmotic flow which develops in the membrane pores is reduced or offset by pressure superposition. The appliance for the membrane electrophoresis comprises at least an at least quadrupartite separation chamber (7), having at least one diluate space (16) and one concentrate space (17) and also a cathode space (18) and an anode space (21) having electrodes as anode (19) and cathode (20), with the individual spaces (16, 17, 18, 21) being separated from each other by ultrafiltration or microfiltration membranes (14, 15); feed lines (22) and discharge lines (23) for the diluate, feed lines (24) and discharge lines (25) for the concentrate, optionally feed lines (26) and discharge lines (27) for the electrode rinsing solution, and also a device (8; 10) or (9; 11) for pressure regulation by means of which a pressure difference, in particular of at least 3 kPa, can be generated between the diluate space (16) and the concentrate space (17).
摘要翻译： 使用微滤或超滤膜进行膜电泳的方法和装置，其中在膜孔中形成的电渗流减少或通过压力叠加抵消。 用于膜电泳的器具至少包括至少四分之一的分离室（7），其具有至少一个稀释空间（16）和一个浓缩空间（17）以及阴极空间（18）和阳极空间（21） 具有作为阳极（19）和阴极（20）的电极，其中各个空间（16,17,18,21）通过超滤或微滤膜（14,15）彼此分离; 用于浓缩物的稀释供料管线（24）和排出管线（25）的进料管线（22）和排出管线（23），用于电极漂洗溶液的任选的进料管线（26）和排出管线（27） 用于压力调节的装置（8; 10）或（9; 11），通过该装置可以在稀释空间（16）和浓缩空间（17）之间产生特别是至少3kPa的压力差。
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公开(公告)号：US20050242030A1
公开(公告)日：2005-11-03
申请号：US11054760
申请日：2005-02-10
申请人： Ralf Lausch , Oscar-Werner Reif , Ulrich Grummert , Stefan Haufe , Holger Linne , Andre Pastor , Gregor Dudziak , Andreas Nickel , Martina Mutter , Michael Traving
发明人： Ralf Lausch , Oscar-Werner Reif , Ulrich Grummert , Stefan Haufe , Holger Linne , Andre Pastor , Gregor Dudziak , Andreas Nickel , Martina Mutter , Michael Traving
CPC分类号： B01D61/50 , B01D57/02 , B01D61/425
摘要： A device and a process are described for membrane electrophoresis or electrofiltration. The device contains at least one input chamber, one output chamber, and one cathode chamber and anode chamber each, whereby the individual chambers are separated from one another by membranes, and are integrated into a permanently attached module with membranes, and whereby the electrodes are integrated into the module, and the module is connected to constructions enabling continuous flow through the input and output chambers, as well as through the electrode chambers. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims. 37 CFR §1.72(b).
摘要翻译： 描述了用于膜电泳或电渗析的装置和方法。 该装置包括至少一个输入室，一个输出室和一个阴极室和阳极室，由此各个室通过膜彼此分离，并且被集成到具有膜的永久附着的模块中，并且由此电极 集成到模块中，并且模块连接到能够连续流过输入和输出室以及通过电极室的构造。 要强调的是，该摘要被提供以符合要求抽象的规则，这将允许搜索者或其他读者快速地确定技术公开的主题。 提交它的理解是，它不会用于解释或限制所附权利要求的范围或含义。 37 CFR§1.72（b）。
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公开(公告)号：US20080156648A1
公开(公告)日：2008-07-03
申请号：US11817461
申请日：2006-03-06
申请人： Gregor Dudziak , Michael Traving , Martina Mutter
发明人： Gregor Dudziak , Michael Traving , Martina Mutter
IPC分类号： B01D61/42
CPC分类号： B01D57/02 , B01D61/425 , C07K1/24 , C07K1/34
摘要： Method for improving selectivity and productivity during purification of charged macromolecules and particles by electrofiltration by means of membranes in the electric filed. The ratio between the electric field and the permeate flow through the membrane is kept constant.
摘要翻译： 通过在电场中通过膜进行电沉积来提高带电大分子和颗粒的纯化期间提高选择性和生产率的方法。 通过膜的电场和渗透液之间的比例保持恒定。
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公开(公告)号：US08252161B2
公开(公告)日：2012-08-28
申请号：US11817461
申请日：2006-03-06
申请人： Gregor Dudziak , Michael Traving , Martina Mutter
发明人： Gregor Dudziak , Michael Traving , Martina Mutter
CPC分类号： B01D57/02 , B01D61/425 , C07K1/24 , C07K1/34
摘要： Method for improving selectivity and productivity during purification of charged macromolecules and particles by electrofiltration by means of membranes in the electric filed. The ratio between the electric field and the permeate flow through the membrane is kept constant.
摘要翻译： 通过在电场中通过膜进行电沉积来提高带电大分子和颗粒的纯化期间提高选择性和生产率的方法。 通过膜的电场和渗透液之间的比例保持恒定。
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公开(公告)号：US20070253986A1
公开(公告)日：2007-11-01
申请号：US10578329
申请日：2004-10-29
申请人： Olaf Stange , Martina Mutter , Tanja Oswald , Mark Schmitz
发明人： Olaf Stange , Martina Mutter , Tanja Oswald , Mark Schmitz
CPC分类号： A61K9/113 , Y10S514/937 , Y10S514/939
摘要： A process is described for the preparation of storage-stable, multiple emulsions of the water/oil/water (W/O/W) type which comprise one or more active ingredients. The process comprises the steps a) stirring the active ingredient into an aqueous phase, b) emulsifying the aqueous phase by passing the aqueous phase through a large-pored, porous membrane into an oil phase, c) phase inversion of the emulsion from b), by cooling the mixture at a cooling rate of at least 0.3 K/min, where an emulsifier is added either to the aqueous phase in a) or to the oil phase in b) or to both phases.
摘要翻译： 描述了制备包含一种或多种活性成分的水/油/水（W / O / W）类型的储存稳定的多重乳液的方法。 该方法包括以下步骤：a）将活性成分搅拌成水相，b）通过将水相通过大孔多孔膜进入油相中乳化水相，c）从b）相转化乳液， 通过以至少0.3K / min的冷却速度冷却混合物，其中将乳化剂加入a）中的水相或b）或两相中的油相中。
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7.发明申请METHOD FOR PURIFYING THERAPEUTIC PROTEINS BY MEANS OF MULTI-STAGE EXTRACTION 审中-公开通过多级萃取法净化治疗性蛋白质的方法公开(公告)号：US20100331530A1
公开(公告)日：2010-12-30
申请号：US12919084
申请日：2009-02-25
申请人： Werner Bäcker , Sven Sommerfeld , Martina Mutter , Paula Alexandra Albuquerque De Jesus Rosa , Maria Raquel Murias Dos Santos Aires-Barosl , Ana Margarida Nunes Da Mata Pires De Azevedo
发明人： Werner Bäcker , Sven Sommerfeld , Martina Mutter , Paula Alexandra Albuquerque De Jesus Rosa , Maria Raquel Murias Dos Santos Aires-Barosl , Ana Margarida Nunes Da Mata Pires De Azevedo
摘要： Method for purifying therapeutic proteins by multi-stage extractive distillation.
摘要翻译： 通过多级萃取蒸馏纯化治疗性蛋白质的方法。
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公开(公告)号：US07943154B2
公开(公告)日：2011-05-17
申请号：US10578329
申请日：2004-10-29
申请人： Olaf Stange , Martina Mutter , Tanja Oswald , Mark Schmitz
发明人： Olaf Stange , Martina Mutter , Tanja Oswald , Mark Schmitz
CPC分类号： A61K9/113 , Y10S514/937 , Y10S514/939
摘要： A process is described for the preparation of storage-stable, multiple emulsions of the water/oil/water (W/O/W) type which comprise one or more active ingredients.The process comprises the steps a) stirring the active ingredient into an aqueous phase, b) emulsifying the aqueous phase by passing the aqueous phase through a large-pored, porous membrane into an oil phase, c) phase inversion of the emulsion from b), by cooling the mixture at a cooling rate of at least 0.3 K/min, where an emulsifier is added either to the aqueous phase in a) or to the oil phase in b) or to both phases.
摘要翻译： 描述了制备包含一种或多种活性成分的水/油/水（W / O / W）类型的储存稳定的多重乳液的方法。 该方法包括以下步骤：a）将活性成分搅拌成水相，b）通过将水相通过大孔多孔膜进入油相中乳化水相，c）从b）相转化乳液， 通过以至少0.3K / min的冷却速度冷却混合物，其中将乳化剂加入a）中的水相或b）或两相中的油相中。
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