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公开(公告)号：US08362210B2
公开(公告)日：2013-01-29
申请号：US13009820
申请日：2011-01-19
CPC分类号： C07K16/2887 , C07K16/2803 , C07K16/2878 , C07K2317/52 , C07K2317/524 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The present invention relates to novel Fc variants that comprise at least one novel amino acid residue which may provide for enhanced effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more Fc receptor or ligand (e.g., Fc gamma R, C1q). Additionally, the Fc variants have altered complement dependent cytotoxicity (CDC) activity and/or antibody-dependent cell-mediated cytotoxicity (ADCC). The invention further provides methods and protocols for the application of said Fc variants, particularly for therapeutic purposes.
摘要翻译： 本发明涉及包含至少一个可提供增强的效应子功能的新的氨基酸残基的新型Fc变体。 更具体地，本发明提供了对一种或多种Fc受体或配体（例如FcγR，C1q）具有修饰的结合亲和力的Fc变体。 另外，Fc变体具有改变的补体依赖性细胞毒性（CDC）活性和/或抗体依赖性细胞介导的细胞毒性（ADCC）。 本发明还提供了用于应用所述Fc变体的方法和方案，特别是用于治疗目的。
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公开(公告)号：US20110236375A1
公开(公告)日：2011-09-29
申请号：US13009820
申请日：2011-01-19
IPC分类号： A61K39/395 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/00 , C07K16/28 , C07K19/00 , C07H21/00
CPC分类号： C07K16/2887 , C07K16/2803 , C07K16/2878 , C07K2317/52 , C07K2317/524 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The present invention relates to novel Fc variants that comprise at least one novel amino acid residue which may provide for enhanced effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more Fc receptor or ligand (e.g., Fc gamma R, C1q). Additionally, the Fc variants have altered complement dependent cytotoxicity (CDC) activity and/or antibody-dependent cell-mediated cytotoxicity (ADCC). The invention further provides methods and protocols for the application of said Fc variants, particularly for therapeutic purposes.
摘要翻译： 本发明涉及包含至少一个可提供增强的效应子功能的新的氨基酸残基的新型Fc变体。 更具体地，本发明提供了对一种或多种Fc受体或配体（例如FcγR，C1q）具有修饰的结合亲和力的Fc变体。 另外，Fc变体具有改变的补体依赖性细胞毒性（CDC）活性和/或抗体依赖性细胞介导的细胞毒性（ADCC）。 本发明还提供了用于应用所述Fc变体的方法和方案，特别是用于治疗目的。
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公开(公告)号：US20130122001A1
公开(公告)日：2013-05-16
申请号：US13747317
申请日：2013-01-22
IPC分类号： C07K16/28
CPC分类号： C07K16/2887 , C07K16/2803 , C07K16/2878 , C07K2317/52 , C07K2317/524 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The present invention relates to novel Fc variants that comprise at least one novel amino acid residue which may provide for enhanced effector function. More specifically, this invention provides Fc variants that have modified binding affinity to one or more Fc receptor or ligand (e.g., Fc gamma R, C1q). Additionally, the Fc variants have altered complement dependent cytotoxicity (CDC) activity and/or antibody-dependent cell-mediated cytotoxicity (ADCC). The invention further provides methods and protocols for the application of said Fc variants, particularly for therapeutic purposes.
摘要翻译： 本发明涉及包含至少一个可提供增强的效应子功能的新的氨基酸残基的新型Fc变体。 更具体地，本发明提供了对一种或多种Fc受体或配体（例如FcγR，C1q）具有修饰的结合亲和力的Fc变体。 另外，Fc变体具有改变的补体依赖性细胞毒性（CDC）活性和/或抗体依赖性细胞介导的细胞毒性（ADCC）。 本发明还提供了用于应用所述Fc变体的方法和方案，特别是用于治疗目的。
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公开(公告)号：US20130209445A1
公开(公告)日：2013-08-15
申请号：US13790991
申请日：2013-03-08
申请人： Gregory A. Lazar , Wei Dang , John Desjarais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
发明人： Gregory A. Lazar , Wei Dang , John Desjarais , Sher Bahadur Karki , Omid Vafa , Robert Hayes , Jost Vielmetter
IPC分类号： C07K16/28
CPC分类号： C07K16/2896 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/32 , C07K2317/14 , C07K2317/34 , C07K2317/41 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.
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公开(公告)号：US20120225058A1
公开(公告)日：2012-09-06
申请号：US13336907
申请日：2011-12-23
申请人： Gregory A. Lazar , Bassil I. Dahiyat , Wei Dang , Sher Bahadur Karki , Omid Vafa
发明人： Gregory A. Lazar , Bassil I. Dahiyat , Wei Dang , Sher Bahadur Karki , Omid Vafa
IPC分类号： A61K39/395 , C07K16/24 , C07K16/28 , A61P29/00 , C12N15/13 , A61P35/00 , A61P37/06 , A61P31/00 , C07K16/00 , C07K19/00
CPC分类号： C07K16/00 , C07K16/2803 , C07K16/32 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要： An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more FcγRs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide.
摘要翻译： 亲本Fc多肽的Fc变体，其中所述Fc变体表现出与一个或多个FcγRs的改变的结合，其中所述Fc变体包含在所述亲本Fc多肽的Fc区中的至少一个氨基酸插入。
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公开(公告)号：US08101720B2
公开(公告)日：2012-01-24
申请号：US12020443
申请日：2008-01-25
申请人： Gregory A. Lazar , Bassil I. Dahiyat , Wei Dang , Sher Bahadur Karki , Omid Vafa
发明人： Gregory A. Lazar , Bassil I. Dahiyat , Wei Dang , Sher Bahadur Karki , Omid Vafa
CPC分类号： C07K16/00 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要： An Fc variant of a parent Fc polypeptide, wherein said Fc variant exhibits altered binding to one or more FcγRs, wherein said Fc variant comprises at least one amino acid insertion in the Fc region of said parent Fc polypeptide.
摘要翻译： 亲本Fc多肽的Fc变体，其中所述Fc变体表现出与一个或多个FcγRs的改变的结合，其中所述Fc变体包含在所述亲本Fc多肽的Fc区中的至少一个氨基酸插入。
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公开(公告)号：US11434295B2
公开(公告)日：2022-09-06
申请号：US13294103
申请日：2011-11-10
申请人： Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Gregory L. Moore , Igor Vostiar
发明人： Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Gregory L. Moore , Igor Vostiar
IPC分类号： A61K39/395 , A61K39/40 , C07K16/00 , C07K16/28 , A61K39/00
摘要： The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.
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公开(公告)号：US09394366B2
公开(公告)日：2016-07-19
申请号：US13689528
申请日：2012-11-29
申请人： Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Gregory L. Moore , Igor Vostiar
发明人： Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Gregory L. Moore , Igor Vostiar
CPC分类号： C07K16/283 , A61K2039/505 , C07K16/00 , C07K16/2803 , C07K16/2851 , C07K16/2878 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/53 , C07K2317/71 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.
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公开(公告)号：US09260523B2
公开(公告)日：2016-02-16
申请号：US13301627
申请日：2011-11-21
申请人： Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Gregory L. Moore , Igor Vostiar
发明人： Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Gregory L. Moore , Igor Vostiar
CPC分类号： C07K16/283 , A61K2039/505 , C07K16/00 , C07K16/2803 , C07K16/2851 , C07K16/2878 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/53 , C07K2317/71 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.
摘要翻译： 本发明涉及结合FcγRIIb+细胞并使细胞表面上的抗原与细胞表面上的FcγRIIb结合的免疫球蛋白，其产生方法和使用免疫球蛋白的方法。
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公开(公告)号：US09079960B2
公开(公告)日：2015-07-14
申请号：US13594619
申请日：2012-08-24
申请人： Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Gregory L. Moore , Igor Vostiar
发明人： Seung Yup Chu , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar , Gregory L. Moore , Igor Vostiar
CPC分类号： C07K16/283 , A61K2039/505 , C07K16/00 , C07K16/2803 , C07K16/2851 , C07K16/2878 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/53 , C07K2317/71 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.
摘要翻译： 本发明涉及结合FcγRIIb+细胞并使细胞表面上的抗原与细胞表面上的FcγRIIb结合的免疫球蛋白，其产生方法和使用免疫球蛋白的方法。
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