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    MYCOBACTERIUM TUBERCULOSIS ANTIGENS AND COMBINATIONS THEREOF HAVING HIGH SEROREACTIVITY
    1.
    发明申请
    MYCOBACTERIUM TUBERCULOSIS ANTIGENS AND COMBINATIONS THEREOF HAVING HIGH SEROREACTIVITY 审中-公开
    MYCOBACTERIUM TUBERCULOSIS抗体及其具有高细胞浓度的组合

    公开(公告)号：US20130345079A1

    公开(公告)日：2013-12-26

    申请号：US13880025

    申请日：2011-08-16

    申请人： Gregory C. Ireton ,  Steven G. Reed

    发明人： Gregory C. Ireton ,  Steven G. Reed

    IPC分类号： G01N33/569

    CPC分类号： G01N33/5695 ,  C07K14/35 ,  C07K2319/00

    摘要： The present invention relates to compositions and fusion proteins containing comprising Mycobacterium sp. antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the diagnosis, treatment and/or prevention of tuberculosis infection.

    摘要翻译： 本发明涉及包含分枝杆菌属（Mycobacterium sp。）的组合物和融合蛋白。 抗原和编码这种组合物的多核苷酸和融合蛋白。 本发明还涉及其用于诊断，治疗和/或预防结核病感染的方法。

    Compounds and methods for diagnosis and treatment of leishmaniasis
    4.
    发明授权
    Compounds and methods for diagnosis and treatment of leishmaniasis 有权
    利什曼病诊断和治疗的化合物和方法

    公开(公告)号：US08865180B2

    公开(公告)日：2014-10-21

    申请号：US12901961

    申请日：2010-10-11

    申请人： Yasuyuki Goto ,  Steven G. Reed

    发明人： Yasuyuki Goto ,  Steven G. Reed

    IPC分类号： A61K39/00 ,  A61K39/02 ,  G01N33/50 ,  G01N33/569 ,  G01N33/68

    CPC分类号： G01N33/56905 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5091 ,  G01N33/6854 ,  G01N2500/00

    摘要： Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.

    摘要翻译： 提供了用于诊断，预防，治疗和检测利什曼病感染和刺激患者免疫应答的化合物和方法。 所公开的化合物包括含有一种或多种利什曼原虫抗原或其变体的至少一种免疫原性部分的多肽和融合蛋白。 另外，公开了筛选具有免疫原性的串联重复蛋白的筛选文库的方法。 描述了可用于预防和治疗利什曼病以及利什曼病感染检测的包含多核苷酸，多肽，融合蛋白及其变体的疫苗和药物组合物。

    Vaccine composition containing synthetic adjuvant
    5.
    发明授权
    Vaccine composition containing synthetic adjuvant 有权
    含有合成佐剂的疫苗组合物

    公开(公告)号：US08840908B2

    公开(公告)日：2014-09-23

    申请号：US13599701

    申请日：2012-08-30

    申请人： Steven G. Reed ,  Darrick Carter

    发明人： Steven G. Reed ,  Darrick Carter

    IPC分类号： A61K39/35 ,  A61K45/06 ,  A61K39/39 ,  A61K39/00

    CPC分类号： A61K39/39 ,  A61K9/107 ,  A61K39/0011 ,  A61K39/008 ,  A61K39/04 ,  A61K39/145 ,  A61K39/35 ,  A61K45/06 ,  A61K2039/55511 ,  A61K2039/55572 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/41 ,  Y02A50/491

    摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.

    摘要翻译： 基于在基本上均匀形式提供的合成的吡喃葡萄糖基脂质佐剂（GLA）中发现有用的免疫佐剂性质，公开了组合物和方法，包括用于诱导或增强免疫应答的疫苗和药物组合物。 在化学上，合成的GLA提供了从批次到批次的一致的疫苗组分，而不会损害天然产物佐剂的污染物或活性的波动。 还提供了疫苗和药物组合物，其包括GLA和抗原，Toll样受体（TLR）激动剂，辅助佐剂和载体如药物载体中的一种或多种。

    COMPOUNDS AND METHODS FOR DIAGNOSIS AND TREATMENT OF LEISHMANIASIS
    8.
    发明申请
    COMPOUNDS AND METHODS FOR DIAGNOSIS AND TREATMENT OF LEISHMANIASIS 有权
    用于诊断和治疗感染的化合物和方法

    公开(公告)号：US20110280902A1

    公开(公告)日：2011-11-17

    申请号：US12901961

    申请日：2010-10-11

    申请人： Yasuyuki Goto ,  Steven G. Reed

    发明人： Yasuyuki Goto ,  Steven G. Reed

    IPC分类号： A61K38/17 ,  A61P37/02 ,  A61P33/02 ,  A61K38/10 ,  C07K14/435 ,  C40B60/12

    CPC分类号： G01N33/56905 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5091 ,  G01N33/6854 ,  G01N2500/00

    摘要： Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.

    摘要翻译： 提供了用于诊断，预防，治疗和检测利什曼病感染和刺激患者免疫应答的化合物和方法。 所公开的化合物包括含有一种或多种利什曼原虫抗原或其变体的至少一种免疫原性部分的多肽和融合蛋白。 另外，公开了筛选具有免疫原性的串联重复蛋白的筛选文库的方法。 描述了可用于预防和治疗利什曼病以及利什曼病感染检测的包含多核苷酸，多肽，融合蛋白及其变体的疫苗和药物组合物。

    Methods and Materials for the Detection of Leishmania Infection
    9.
    发明申请
    Methods and Materials for the Detection of Leishmania Infection 有权
    检测利什曼原虫感染的方法和材料

    公开(公告)号：US20110159528A1

    公开(公告)日：2011-06-30

    申请号：US13012398

    申请日：2011-01-24

    申请人： Raymond L. Houghton ,  Steven G. Reed ,  Syamal Raychaudhuri

    发明人： Raymond L. Houghton ,  Steven G. Reed ,  Syamal Raychaudhuri

    IPC分类号： G01N33/569

    CPC分类号： G01N33/56905 ,  Y02A50/55

    摘要： The present invention provides rapid diagnostic assays for the detection of Leishmania which can readily be used in the field, leading to more rapid treatment. In certain embodiments, the inventive assays, including ELISA and lateral flow assays, employ antibodies that may be effectively employed to detect the Leishmania major antigen TSA, which is present in both promastigotes grown in culture and in amastigotes. Such assays may be employed to detect the presence of cutaneous leishmaniasis in a subject using scrapings, biopsies, and/or aspirates taken from cutaneous lesions.

    摘要翻译： 本发明提供了用于检测利什曼原虫的快速诊断测定法，其可以容易地用于该领域，导致更快速的治疗。 在某些实施方案中，本发明的测定法，包括ELISA和侧向流动测定，采用可有效地用于检测在培养物中生长的两种前鞭毛体中存在的利什曼原虫主要抗原TSA的抗体。 可以使用这种测定法来检测受试者中使用刮皮，活组织检查和/或从皮肤病变获取的吸出物中皮肤利什曼病的存在。