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    Method for treating an aortic valve
    6.
    发明授权
    Method for treating an aortic valve 有权
    治疗主动脉瓣的方法

    公开(公告)号：US09241788B2

    公开(公告)日：2016-01-26

    申请号：US13529955

    申请日：2012-06-21

    申请人： Jibin Yang ,  Matthew L. Pease ,  Brandon G. Walsh

    发明人： Jibin Yang ,  Matthew L. Pease ,  Brandon G. Walsh

    IPC分类号： A61F2/24 ,  A61F2/848 ,  A61F2/91 ,  A61F2/92

    CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2/848 ,  A61F2/91 ,  A61F2/92 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/006 ,  Y10S623/90

    摘要： Expandable, percutaneously deployable, prosthetic heart valves and systems for minimally invasive replacement of damaged or diseased native aortic valves comprise an expandable, tubular stent body and a unidirectional valve assembly. Embodiments of the stent body comprise an annulus anchoring section, a sinus section, and an outflow section, with the outflow section flared outwardly from the sinus section in an expanded configuration. Embodiments of the stent body are self-expanding, comprising, for example nitinol. The valve assembly disposed within the sinus section of the stent body and sutured thereto. Embodiments of the valve assembly comprise three leaflets, each leaflet comprising a curved outer edge sutured to the sinus section of the stent body, and a coapting free edge. Embodiments of the valve leaflets comprise pericardium, for example, porcine pericardium. Embodiments of the prosthetic heart valve have a contracted configuration dimensioned for percutaneous delivery thereof.

    摘要翻译： 可扩展的，经皮可展开的假体心脏瓣膜和用于微创更换受损或患病的天然主动脉瓣的系统包括可扩张的管状支架体和单向阀组件。 支架主体的实施例包括环形锚固部分，窦部分和流出部分，其中流出部分以扩张构型从窦部向外扩张。 支架体的实施例是自膨胀的，包括例如镍钛诺。 该阀组件设置在支架主体的窦区内并缝合到其上。 瓣膜组件的实施例包括三个小叶，每个小叶包括缝合到支架主体的窦部分的弯曲外边缘以及自由边缘。 瓣膜小叶的实施例包括心包膜，例如猪心包膜。 假体心脏瓣膜的实施例具有尺寸用于经皮递送的收缩构造。

    Prosthetic heart valve having flared outflow section
    7.
    发明授权
    Prosthetic heart valve having flared outflow section 有权
    假性心脏瓣膜有扩张流出部分

    公开(公告)号：US08206438B2

    公开(公告)日：2012-06-26

    申请号：US13029033

    申请日：2011-02-16

    申请人： Jibin Yang ,  Matthew L. Pease ,  Brandon G. Walsh

    发明人： Jibin Yang ,  Matthew L. Pease ,  Brandon G. Walsh

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2/848 ,  A61F2/91 ,  A61F2/92 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/006 ,  Y10S623/90

    摘要： Expandable, percutaneously deployable, prosthetic heart valves and systems for minimally invasive replacement of damaged or diseased native aortic valves comprise an expandable, tubular stent body and a unidirectional valve assembly. Embodiments of the stent body comprise an annulus anchoring section, a sinus section, and an outflow section, with the outflow section flared outward from the sinus section in an expanded configuration. Embodiments of the stent body are self-expanding, comprising, for example nitinol. The valve assembly disposed within the sinus section of the stent body and sutured thereto. Embodiments of the valve assembly comprise three leaflets, each leaflet comprising a curved outer edge sutured to the sinus section of the stent body, and a coapting free edge. Embodiments of the valve leaflets comprise pericardium. Embodiments of the prosthetic heart valve have a contracted configuration dimensioned for percutaneous delivery thereof.

    摘要翻译： 可扩展的，经皮可展开的假体心脏瓣膜和用于微创更换受损或患病的天然主动脉瓣的系统包括可扩张的管状支架体和单向阀组件。 支架主体的实施例包括环形锚定部分，窦部分和流出部分，其中流出部分以扩张构型从窦部向外扩张。 支架体的实施例是自膨胀的，包括例如镍钛诺。 该阀组件设置在支架主体的窦区内并缝合到其上。 瓣膜组件的实施例包括三个小叶，每个小叶包括缝合到支架主体的窦部分的弯曲外边缘以及自由边缘。 瓣膜小叶的实施例包括心包。 假体心脏瓣膜的实施例具有尺寸用于经皮递送的收缩构造。

    Rolled minimally invasive heart valves
    8.
    发明授权
    Rolled minimally invasive heart valves 有权
    滚动微创心脏瓣膜

    公开(公告)号：US07276084B2

    公开(公告)日：2007-10-02

    申请号：US10653843

    申请日：2003-09-02

    申请人： Jibin Yang ,  Matthew L. Pease ,  Brandon G. Walsh

    发明人： Jibin Yang ,  Matthew L. Pease ,  Brandon G. Walsh

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2/848 ,  A61F2/91 ,  A61F2/92 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/006 ,  Y10S623/90

    摘要： Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The one-piece stents may include an annulus anchoring section, a sinus section with the membranes attached over sinus apertures, and a rigid outflow section. The two-piece stent may include a primary stent to provide a tubular base at the annulus, and a secondary stent having the membranes that couples within the primary stent. Lockout tabs to secure the stents in their expanded shapes are provided. Also, alignment structure may be provided to ensure concentric unfurling. Anchoring barbs at the stent edges or in the stent body secure the valve within the annulus. Methods of implantation are also provided.

    摘要翻译： 公开了用于微创瓣膜置换手术的可扩张心脏瓣膜。 这些阀门被卷入第一个收缩构造，用于微创输送，然后在植入部位展开或展开。 单件和两件式支架可与多个柔性成叶膜结合使用。 一体式支架可以包括环形锚固部分，具有附着在窦口上的膜的窦部分和刚性流出部分。 两件式支架可以包括在环形空间处提供管状基部的主支架，以及具有在主支架内连接的膜的辅助支架。 提供锁定标签以将支架固定在其扩展形状中。 此外，可以提供对准结构以确保同心展开。 在支架边缘或支架主体中锚定倒钩固定瓣膜内的瓣膜。 还提供了植入方法。

    Two-part expandable heart valve
    9.
    发明授权
    Two-part expandable heart valve 有权
    两部分可扩张心脏瓣膜

    公开(公告)号：US07947072B2

    公开(公告)日：2011-05-24

    申请号：US11749722

    申请日：2007-05-16

    申请人： Jibin Yang ,  Matthew L. Pease ,  Brandon G. Walsh

    发明人： Jibin Yang ,  Matthew L. Pease ,  Brandon G. Walsh

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2412 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2/848 ,  A61F2/91 ,  A61F2/92 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0054 ,  A61F2250/006 ,  Y10S623/90

    摘要： Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The one-piece stents may include an annulus anchoring section, a sinus section with the membranes attached over sinus apertures, and a rigid outflow section. The two-piece stent may include a primary stent to provide a tubular base at the annulus, and a secondary stent having the membranes that couples within the primary stent. Lockout tabs to secure the stents in their expanded shapes are provided. Also, alignment structure may be provided to ensure concentric unfurling. Anchoring barbs at the stent edges or in the stent body secure the valve within the annulus. Methods of implantation are also provided.

    摘要翻译： 公开了用于微创瓣膜置换手术的可扩张心脏瓣膜。 这些阀门被卷入第一个收缩构造，用于微创输送，然后在植入部位展开或展开。 单件和两件式支架可与多个柔性成叶膜结合使用。 一体式支架可以包括环形锚固部分，具有附着在窦口上的膜的窦部分和刚性流出部分。 两件式支架可以包括在环形空间处提供管状基部的主支架，以及具有在主支架内连接的膜的辅助支架。 提供锁定标签以将支架固定在其扩展形状中。 此外，可以提供对准结构以确保同心展开。 在支架边缘或支架主体中锚定倒钩固定瓣膜内的瓣膜。 还提供了植入方法。

    Rolled minimally-invasive heart valves and methods of manufacture
    10.
    发明授权
    Rolled minimally-invasive heart valves and methods of manufacture 有权
    滚动的微创心脏瓣膜和制造方法

    公开(公告)号：US07374571B2

    公开(公告)日：2008-05-20

    申请号：US10286009

    申请日：2002-11-01

    申请人： Matthew L. Pease ,  Brandon G. Walsh ,  Jibin Yang

    发明人： Matthew L. Pease ,  Brandon G. Walsh ,  Jibin Yang

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/848 ,  A61F2/92 ,  A61F2220/0016 ,  A61F2220/0075

    摘要： Expandable heart valves for minimally invasive valve replacement surgeries are disclosed. The valves are rolled into a first, contracted configuration for minimally invasive delivery using a catheter, and then unrolled or unfurled at the implantation site. One- and two-piece stents may be used in conjunction with a plurality of flexible leaflet-forming membranes. The stents may include an annulus section, a sinus section with the membranes attached over sinus apertures, and an outflow section. Lockout tabs and making slots secure the stents in their expanded shapes. Alignment structure ensures concentric unfurling of the stent. Anchoring elements at the stent edges or in the stent body secure the valve within the annulus. A method of manufacture includes shape setting the sheet-like stent to ensure an outward bias during deployment. The stent may also include dear tracks for engagement with a gear mechanism for deployment. The stent is desirably made of a superelastic material such as Nitinol and may have areas removed or thinned to reduce the bending stresses when rolled into its small spiral for catheter delivery.

    摘要翻译： 公开了用于微创瓣膜置换手术的可扩张心脏瓣膜。 使用导管将瓣膜卷成第一收缩构造用于微创递送，然后在植入部位展开或展开。 单件和两件式支架可与多个柔性成叶膜结合使用。 支架可以包括环形部分，具有附接在窦孔上的膜的窦部分和流出部分。 锁定标签和插槽将支架固定在其扩展形状中。 对准结构确保支架的同心展开。 在支架边缘处或支架主体中的锚定元件将瓣膜固定在环形空间内。 一种制造方法包括使片状支架的形状设定，以确保在展开期间向外偏置。 支架还可以包括用于与用于展开的齿轮机构接合的亲爱的轨道。 支架理想地由诸如镍钛诺的超弹性材料制成，并且可以具有去除或变薄的区域，以便在卷入其用于导管递送的小螺旋时减小弯曲应力。