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1.发明申请DEVICES, COMPOSITIONS AND METHODS UTILIZING EP4 AND EP2 RECEPTOR AGONISTS FOR PREVENTING, REDUCING OR TREATING CAPSULAR CONTRACTURE 审中-公开使用EP4和EP2受体激动剂的装置，组合物和方法，用于预防，减少或治疗CAPSULAR合同公开(公告)号：US20120259413A1
公开(公告)日：2012-10-11
申请号：US13193774
申请日：2011-07-29
申请人： Guang-Liang Jiang , Wha Bin Im , Gurpreet Ahluwalia , Frederick C. Beddingfield , Larry A. Wheeler , Scott M. Whitcup
发明人： Guang-Liang Jiang , Wha Bin Im , Gurpreet Ahluwalia , Frederick C. Beddingfield , Larry A. Wheeler , Scott M. Whitcup
IPC分类号： A61F2/12 , A61M35/00 , A61P43/00 , A61K31/381 , A61K31/4015
CPC分类号： A61L15/44 , A61L15/40 , A61L27/34 , A61L27/54 , A61L2300/436 , A61L2430/04 , C08L89/00
摘要： Provided are devices, compositions and methods utilizing EP4 and EP2 receptor agonists for preventing, reducing, or treating capsular contracture occurring in response to the implantation of breast prostheses.
摘要翻译： 提供了利用EP4和EP2受体激动剂预防，减少或治疗响应于乳房假体植入而发生的荚膜挛缩的装置，组合物和方法。
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公开(公告)号：US20120046332A1
公开(公告)日：2012-02-23
申请号：US13211715
申请日：2011-08-17
IPC分类号： A61K31/381 , A61K31/4025 , A61P27/02 , A61K31/4015
CPC分类号： A61K31/381 , A61K9/0048 , A61K9/0051 , A61K31/4015 , A61K31/4025 , A61K31/539 , A61K31/559 , A61K2300/00
摘要： Disclosed herein are compositions and methods for treating corneal haze. Compositions and methods of use comprise therapeutically effective amounts of compounds that agonize the EP2 and/or EP4 receptor. Administration of the disclosed compounds can prevent and treat corneal haze development.
摘要翻译： 本文公开了治疗角膜混浊的组合物和方法。 组合物和使用方法包括治疗有效量的激动EP2和/或EP4受体的化合物。 所公开的化合物的施用可以预防和治疗角膜混浊发展。
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公开(公告)号：US20120136011A1
公开(公告)日：2012-05-31
申请号：US13194078
申请日：2011-07-29
申请人： Guang L. Jiang , Wha-Bin Im , Frederick C. Beddingfield , Larry A. Wheeler , Scott M. Whitcup , Robert M. Burk
发明人： Guang L. Jiang , Wha-Bin Im , Frederick C. Beddingfield , Larry A. Wheeler , Scott M. Whitcup , Robert M. Burk
IPC分类号： A61K31/519 , A61K31/343 , A61K31/4015 , A61P17/02 , A61K31/216 , A61K31/4025 , A61K31/421 , A61K31/381 , A61K31/192
CPC分类号： A61K31/381 , A61K8/49 , A61K2800/91 , A61Q19/08
摘要： The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles.
摘要翻译： 本公开提供了治疗皮肤瑕疵的组合物和方法。 组合物包含治疗有效量的用于治疗皮肤瑕疵如化合物，伤口，皱纹和皱纹的化合物。
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公开(公告)号：US20120142684A1
公开(公告)日：2012-06-07
申请号：US13306637
申请日：2011-11-29
申请人： Robert M. Burk , Wha Bin Im , Scott M. Whitcup
发明人： Robert M. Burk , Wha Bin Im , Scott M. Whitcup
IPC分类号： A61K8/49 , A61K31/343 , A61K31/519 , A61K31/421 , A61K31/19 , A61K8/36 , A61K31/215 , A61K8/46 , A61K31/4015 , A61P17/02 , A61P17/00 , A61Q19/08 , A61K31/5377 , A61K31/196 , A61K8/42 , A61K31/381
CPC分类号： A61K9/0014 , A61K8/365 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61K8/4913 , A61K8/4986 , A61K31/167 , A61K31/519 , A61K31/559 , A61K2800/78 , A61Q19/08
摘要： The disclosure provides compositions and methods for treating a skin blemish. The compositions comprise a therapeutically effective amount of a compound useful for treating skin blemishes such as wounds, scars and wrinkles.
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公开(公告)号：US20110152328A1
公开(公告)日：2011-06-23
申请号：US12988168
申请日：2009-04-13
申请人： Scott M. Whitcup , Robert M. Burk , David W. Old , Yariv Donde , Wha-Bin Im , Mark A. Holoboski
发明人： Scott M. Whitcup , Robert M. Burk , David W. Old , Yariv Donde , Wha-Bin Im , Mark A. Holoboski
IPC分类号： A61K31/426 , A61K31/192 , A61K31/4025 , A61K31/4155 , A61K31/421 , A61K31/427 , A61K31/381 , A61P27/06
CPC分类号： A61K45/06 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/427 , A61K31/557 , A61K31/5575 , A61K31/559 , A61K2300/00
摘要： Disclosed herein is method of treating glaucoma or ocular hypertension comprising administering a prostaglandin agonist and a second therapeutically active agent to a mammal in need thereof, wherein said second therapeutically active agent is selected from: β-Blockers, Adrenergic Agonists, non-selective adrenergic agonists, α2-selective adrenergic agonists, Carbonic Anhydrase Inhibitors, Cholinergic Agonists, direct acting cholinergic agonists, chlolinesterase inhibitors, Glutamate Antagonists, Ca2+ channel blockers, Prostamides, Prostaglandins, Cannabinoids, and combinations thereof. Compositions and medicaments containing a combination of these two active agents are also disclosed.
摘要翻译： 本文公开了治疗青光眼或高眼压症的方法，其包括向有需要的哺乳动物施用前列腺素激动剂和第二治疗活性剂，其中所述第二治疗活性剂选自：β-阻滞剂，肾上腺素能激动剂，非选择性肾上腺素能 激动剂，α2-选择性肾上腺素能激动剂，碳酸酐酶抑制剂，胆碱能激动剂，直接作用的胆碱能激动剂，胆碱酯酶抑制剂，谷氨酸拮抗剂，Ca2 +通道阻断剂，前列腺素，大麻素及其组合。 还公开了含有这两种活性剂的组合的组合物和药物。
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公开(公告)号：US07872045B2
公开(公告)日：2011-01-18
申请号：US11130863
申请日：2005-05-16
申请人： Robert M. Burk , Mark Holoboski , Scott M. Whitcup , Wha-Bin Im
发明人： Robert M. Burk , Mark Holoboski , Scott M. Whitcup , Wha-Bin Im
IPC分类号： A61K31/215 , A61K31/695
CPC分类号： A61K31/559 , A61K31/557 , A61K31/5575 , A61K31/675 , A61K45/06 , A61K2300/00
摘要： A method is disclosed herein comprising administering a compound and a second drug to an eye of a mammal for the treatment of glaucoma or the reduction of intraocular pressure, said compound represented by the general formula I; wherein A, B, D, X, Y, Z, R1, R3 and R4 are as defined in the specification.
摘要翻译： 本文公开的方法包括向哺乳动物的眼睛施用化合物和第二药物用于治疗青光眼或降低眼内压，所述通式I表示的化合物; 其中A，B，D，X，Y，Z，R1，R3和R4如说明书中所定义。
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7.发明授权Treating neurological disorders using selective antagonists of persistent sodium current 有权使用持续钠电流的选择性拮抗剂治疗神经障碍公开(公告)号：US08124612B2
公开(公告)日：2012-02-28
申请号：US11326263
申请日：2006-01-05
IPC分类号： A01N43/40 , A01N43/82 , A61K31/435 , A61K31/44 , A61K31/41
CPC分类号： A61K31/381 , A61K31/00 , A61K31/136 , A61K31/235 , A61K31/4439
摘要： The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
摘要翻译： 本发明提供了通过向哺乳动物施用有效量的相对于瞬时钠电流具有至少20倍的持续钠电流选择性的选择性持续性钠通道拮抗剂来治疗哺乳动物神经系统疾病的方法。
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8.发明授权Treating neurological disorders using selective antagonists of persistent sodium current 有权使用持续钠电流的选择性拮抗剂治疗神经障碍公开(公告)号：US07705055B2
公开(公告)日：2010-04-27
申请号：US11326036
申请日：2006-01-05
CPC分类号： A61K31/381 , A61K31/00 , A61K31/136 , A61K31/235 , A61K31/4439
摘要： The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
摘要翻译： 本发明提供了通过向哺乳动物施用有效量的相对于瞬时钠电流具有至少20倍的持续钠电流选择性的选择性持续性钠通道拮抗剂来治疗哺乳动物神经系统疾病的方法。
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公开(公告)号：US07060723B2
公开(公告)日：2006-06-13
申请号：US10928949
申请日：2004-08-27
CPC分类号： A61K31/381 , A61K31/00 , A61K31/136 , A61K31/235 , A61K31/4439
摘要： The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
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10.发明授权公开(公告)号：US07728034B2
公开(公告)日：2010-06-01
申请号：US11326264
申请日：2006-01-05
CPC分类号： A61K31/381 , A61K31/00 , A61K31/136 , A61K31/235 , A61K31/4439
摘要： The present invention provides methods of treating neurological disorders in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
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