公开(公告)号：US20050059002A1

公开(公告)日：2005-03-17

申请号：US10485313

申请日：2002-07-30

申请人： Guiying Nie ,  Lois Salamonsen ,  Ying Li ,  Anne Hampton ,  John Findlay

发明人： Guiying Nie ,  Lois Salamonsen ,  Ying Li ,  Anne Hampton ,  John Findlay

IPC分类号： A61K31/7088 ,  A61K38/00 ,  A61K38/48 ,  A61K38/57 ,  A61P15/00 ,  C07K14/65 ,  C07K14/71 ,  C07K16/40 ,  C12N9/64 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/72

CPC分类号： C12N9/6424 ,  A61K38/00 ,  C07K16/40

摘要： The invention relates to a enzyme predicted to be a serine protease, which is specifically expressed in association with embryo implantation and placentation in pregnant uterus. The enzyme of the invention is useful in the evaluation of fertility and monitoring of early pregnancy, placental development and function, fetal development, parturition, and conditions such as pre-eclampsia, intrauterine growth restriction, early abortion, abnormal uterine bleeding, endometriosis, and cancers, and may provide a potential target for contraception. It may also be important in diseases of the heart, testis or ovary, and may play a role in muscle function, including cardiac muscle, skeletal muscle, lung and the diaphragm. In addition the enzyme of the invention is useful in the screening of candidate drugs for fertility control or for treatment of fertility-related disorders.

摘要翻译： 本发明涉及一种预测为丝氨酸蛋白酶的酶，其特异性表达与怀孕子宫中的胚胎植入和胎盘相关。 本发明的酶可用于评估生育力和监测早孕，胎盘发育和功能，胎儿发育，分娩以及先兆子痫，子宫内生长受限，早期流产，异常子宫出血，子宫内膜异位症和 癌症，并可能提供避孕的潜在目标。 在心脏，睾丸或卵巢的疾病中也可能是重要的，并且可能在肌肉功能中起作用，包括心肌，骨骼肌，肺和隔膜。 此外，本发明的酶可用于筛选候选药物用于生育控制或用于治疗生育相关疾病。

公开(公告)号：US20050106134A1

公开(公告)日：2005-05-19

申请号：US10485508

申请日：2002-07-31

申请人： Guiying Nie ,  Lois Salamonsen ,  John Findlay

发明人： Guiying Nie ,  Lois Salamonsen ,  John Findlay

IPC分类号： A61K38/00 ,  C12N9/64 ,  C12N15/57 ,  C12Q1/68 ,  C12Q1/6876 ,  G01N33/68 ,  A61K38/48

CPC分类号： C12N9/6424 ,  A61K38/00 ,  C12Q1/6876 ,  C12Q2600/158 ,  G01N33/689 ,  G01N2333/96433 ,  G01N2800/368

摘要： This invention relates to the role of the enzyme proprotein convertase 5/6 in pregnancy, and in particular to the detection or modulation of proprotein convertase 5/6 and its isoforms in the uterus. This enzyme is useful in the control of fertility, the monitoring of early pregnancy, and for the detection of uterine receptivity. The invention also relates to methods of screening for compounds which have the ability to modulate the activity or expression of proprotein convertase 5/6, which may be useful in regulating fertility in mammals. Novel forms of proprotein convertase 5/6 are also disclosed and claimed.

摘要翻译： 本发明涉及酶前体蛋白转化酶5/6在怀孕中的作用，特别涉及在子宫中检测或调节前蛋白转化酶5/6及其同种型。 这种酶可用于控制生育力，监测早孕和检测子宫受体。 本发明还涉及筛选具有调节前体蛋白转化酶5/6的活性或表达的能力的化合物的方法，其可用于调节哺乳动物的生育力。 蛋白转化酶5/6的新型形式也被公开并要求保护。

公开(公告)号：US06532929B2

公开(公告)日：2003-03-18

申请号：US09817510

申请日：2001-03-26

申请人： John M. Antonevich ,  Timothy J. Buerkle ,  John Findlay

发明人： John M. Antonevich ,  Timothy J. Buerkle ,  John Findlay

IPC分类号： F02F700

CPC分类号： F02F7/006 ,  F02F1/24 ,  F02F2007/0041

摘要： A fastener for venting gas around the shank of the fastener. The present invention includes various embodiments for venting gases such as combustion gases that seep from a head gasket of an internal combustion engine to the area around the shank of a cylinder head bolt, as one example. The various vent paths include vent paths directly through the bolt, past the bearing surface of the bolted member, or past a washer between the fastener and the bolted member. These vent paths prevent gases from building up in the chamber between the fastener shank and the clearance hole of the bolted member.

公开(公告)号：US07568254B2

公开(公告)日：2009-08-04

申请号：US11111469

申请日：2005-04-21

申请人： Christopher R. Duncan ,  John Findlay

发明人： Christopher R. Duncan ,  John Findlay

IPC分类号： A47L11/16 ,  A47L11/40

CPC分类号： A47L11/4005 ,  A47L11/16 ,  A47L11/293 ,  A47L11/4058

摘要： The disclosure relates to the floor scrubbing or finishing machines. There is provided a machine for scrubbing or finishing a floor surface comprising carriage means adapted for translational movement over a floor surface, a workhead, an electric motor carried by the carriage means and arranged in use to drive the workhead and battery support means adapted in use to support at least one battery as a source of electric power for driving the electric motor, wherein said battery support means are adapted to support said at least one battery so that said at least one battery can be positioned in a selected one of a range of positions relative to said workhead whereby the loading on said workhead can be varied as required.

摘要翻译： 本公开涉及地板擦洗或精加工机。 提供了一种用于擦洗或整理地板表面的机器，其包括适于在地板表面上的平移运动的托架装置，工作头，由托架装置承载的电动马达，并布置成用于驱动适于使用的工作头和电池支撑装置 以支持至少一个电池作为用于驱动电动机的电力源，其中所述电池支撑装置适于支撑所述至少一个电池，使得所述至少一个电池可以被定位在选定的一个 相对于所述工作头的位置，由此可以根据需要改变所述工作头上的装载。

公开(公告)号：US06812356B2

公开(公告)日：2004-11-02

申请号：US10254972

申请日：2002-09-26

申请人： John Findlay ,  Ghislain Deslongchamps ,  Guoqiang Li

发明人： John Findlay ,  Ghislain Deslongchamps ,  Guoqiang Li

IPC分类号： C07D30514

CPC分类号： C07D305/14 ,  Y02P20/55

摘要： 9-dihydro-13-acetylbaccatin III, one of the chemicals obtained from Taxus canadensis is used to produce, inter alia, 10-decetylbaccatin III, a useful intermediate for the preparation of paclitaxel and analogues thereof The 9-dihydro-13-acetylbaccatin III is converted into the 10-deacetylbaccatin III by a simple three step process involving (a) replacement of the C-7 hydroxyl group of tho 9-dihydro compound with a protecting group, (b) the oxidizing of the C-7 protected compound to produce a C-9 ketone, and (c) the deprotecting of the C-9 ketone to produce 10-deacetylbaccatin III.

摘要翻译： 9-二氢-13-乙酰浆果赤霉素III是从加拿大红豆杉获得的化学药品之一，尤其用于制备10-癸基浆果赤霉素III，其是制备紫杉醇及其类似物的有用中间体9-二氢-13-乙酰浆果赤霉素III 通过简单的三步法转化为10-脱乙酰基浆果赤霉素III，其包括（a）用保护基置换tho-二氢化合物的C 7羟基，（b）将C-7保护的化合物氧化成 产生C-9酮，和（c）C-9酮的脱保护产生10-脱乙酰基浆果赤霉素III。

公开(公告)号：US20050246845A1

公开(公告)日：2005-11-10

申请号：US11111469

申请日：2005-04-21

申请人： Christopher Duncan ,  John Findlay

发明人： Christopher Duncan ,  John Findlay

IPC分类号： A47L11/16 ,  A47L11/293 ,  A47L11/40

CPC分类号： A47L11/4005 ,  A47L11/16 ,  A47L11/293 ,  A47L11/4058

摘要： The disclosure relates to the floor scrubbing or finishing machines. There is provided a machine for scrubbing or finishing a floor surface comprising carriage means adapted for translational movement over a floor surface, a workhead, an electric motor carried by the carriage means and arranged in use to drive the workhead and battery support means adapted in use to support at least one battery as a source of electric power for driving the electric motor, wherein said battery support means are adapted to support said at least one battery so that said at least one battery can be positioned in a selected one of a range of positions relative to said workhead whereby the loading on said workhead can be varied as required.

摘要翻译： 本公开涉及地板擦洗或精加工机。 提供了一种用于擦洗或整理地板表面的机器，其包括适于在地板表面上的平移运动的托架装置，工作头，由托架装置承载的电动马达，并布置成用于驱动适于使用的工作头和电池支撑装置 以支持至少一个电池作为用于驱动电动机的电力源，其中所述电池支撑装置适于支撑所述至少一个电池，使得所述至少一个电池可以被定位在选定的一个 相对于所述工作头的位置，由此可以根据需要改变所述工作头上的装载。