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    Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base
    5.
    发明授权
    Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base 失效
    基于肝素，糖胺聚糖或类肝素的制剂，使用制剂和制剂基础

    公开(公告)号：US07393840B2

    公开(公告)日：2008-07-01

    申请号：US10296441

    申请日：2001-05-29

    申请人： Jörg Rosenberg ,  Jörg Breitenbach ,  Dieter Herr ,  Volker Laux ,  Robert Heger

    发明人： Jörg Rosenberg ,  Jörg Breitenbach ,  Dieter Herr ,  Volker Laux ,  Robert Heger

    IPC分类号： A61N31/747

    CPC分类号： A61K9/1635 ,  A61K9/1617 ,  A61K9/1652 ,  A61K31/726 ,  A61K31/727

    摘要： The present invention relates to formulations based on at least one heparin, glycosaminoglycan or heparinoid and on a formulation base with a lipid component and a polymer component. The use of this formulation as drug form for oral administration of at least one heparin, glycosaminoglycan or heparinoid, and also a process for producing the formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as drug form, advantageously using melt extrusion, are described. The lipid component advantageously has active ingredient-promoting properties, while the polymer component is soluble or swellable. At least parts of the lipid component are embedded in a polymer matrix, preferably in the form of a molecular dispersion. The formulations can form emulsions in water or aqueous liquids.

    摘要翻译： 本发明涉及基于至少一种肝素，糖胺聚糖或类肝素的制剂，以及具有脂质组分和聚合物组分的制剂基质。 使用这种制剂作为口服给药至少一种肝素，糖胺聚糖或类肝素的药物形式，以及通过混合制剂组分以形成塑料混合物并在适当时制备制剂作为药物来制备制剂的方法 描述了有利地使用熔体挤出的形式。 脂质组分有利地具有活性成分促进性质，而聚合物组分是可溶的或可溶胀的。 至少部分脂质组分嵌入聚合物基质中，优选以分子分散体的形式。 制剂可以在水或含水液体中形成乳液。

    AQUEOUS DISPERSIONS OF CROSS-LINKED, TERTIARY ESTER GROUPS CONTAINING EMULSION POLYMERISATES AND WATER-ABSORBENT MATERIALS ON A CARRIER MATERIAL MADE THEREOF
    9.
    发明申请
    AQUEOUS DISPERSIONS OF CROSS-LINKED, TERTIARY ESTER GROUPS CONTAINING EMULSION POLYMERISATES AND WATER-ABSORBENT MATERIALS ON A CARRIER MATERIAL MADE THEREOF 审中-公开
    含有乳液聚合物和其吸收材料的交联聚合物的季铵盐分散体及其载体材料的分散性

    公开(公告)号：US20100189994A1

    公开(公告)日：2010-07-29

    申请号：US12376797

    申请日：2007-08-06

    申请人： Marc Bothe ,  Hermann Seyffer ,  Mirjam Herrlich-Loos ,  Robert Heger ,  Matthias Weismantel

    发明人： Marc Bothe ,  Hermann Seyffer ,  Mirjam Herrlich-Loos ,  Robert Heger ,  Matthias Weismantel

    IPC分类号： B32B27/04 ,  C09K3/00 ,  B32B27/36 ,  B32B27/06

    CPC分类号： C08F220/18 ,  A61L15/60 ,  C08F220/40 ,  Y10T428/249991 ,  Y10T428/31794 ,  Y10T442/2484

    摘要： Aqueous dispersions of crosslinked emulsion polymers comprising tertiary ester groups, comprising (a) at least 50% by weight of an ester derived from a tertiary alcohol and an ethylenically unsaturated C3 to C5 carboxylic acid, (b) 0.001% to 5.0% by weight of at least one compound having at least two ethylenically unsaturated double bonds, and (c) 0% to 49.999% by weight of at least one other monoethylenically unsaturated compound in interpolymerized form and having an average particle size of not more than 1000 nm, and water-absorbing materials obtainable by coating a backing material with the aqueous dispersion described of crosslinked emulsion polymers comprising tertiary ester groups, drying and heating the thus treated backing material to a temperature of at least 140° C. to form carboxyl groups from the tertiary ester groups of the emulsion polymer and at least partly neutralizing the carboxyl groups, and also the use of the water-absorbing materials as an absorbent for water and aqueous fluids.

    摘要翻译： 包含叔酯基团的交联乳液聚合物的水分散体，包含（a）至少50重量％的衍生自叔醇和烯属不饱和C3至C5羧酸的酯，（b）0.001重量％至5.0重量％ 至少一种具有至少两个烯键式不饱和双键的化合物，和（c）0〜49.999％重量的至少一种互聚形式的平均粒径不大于1000nm的其它单烯属不饱和化合物，以及水 - 通过用包含叔酯基团的交联乳液聚合物描述的水性分散体涂覆背衬材料获得的吸收材料，干燥并将由此处理的背衬材料加热至至少140℃的温度以从叔酯基团形成羧基 的乳液聚合物并且至少部分中和羧基，并且还使用吸水材料作为水的吸收剂 d含水流体。