摘要:
A method for detecting fetal anatomic features in ultrasound images includes providing an ultrasound image of a fetus, specifying an anatomic feature to be detected in a region S determined by parameter vector θ, providing a sequence of probabilistic boosting tree classifiers, each with a pre-specified height and number of nodes. Each classifier computes a posterior probability P(y|S) where yε{−1,+1}, with P(y=+1|S) representing a probability that region S contains the feature, and P(y=−1|S) representing a probability that region S contains background information. The feature is detected by uniformly sampling a parameter space of parameter vector θ using a first classifier with a sampling interval vector used for training said first classifier, and having each subsequent classifier classify positive samples identified by a preceding classifier using a smaller sampling interval vector used for training said preceding classifier. Each classifier forms a union of its positive samples with those of the preceding classifier.
摘要:
A method for detecting fetal anatomic features in ultrasound images includes providing an ultrasound image of a fetus, specifying an anatomic feature to be detected in a region S determined by parameter vector θ, providing a sequence of probabilistic boosting tree classifiers, each with a pre-specified height and number of nodes. Each classifier computes a posterior probability P(y|S) where yε{−1,+1}, with P(y=+1|S) representing a probability that region S contains the feature, and P(y=−1|S) representing a probability that region S contains background information. The feature is detected by uniformly sampling a parameter space of parameter vector θ using a first classifier with a sampling interval vector used for training said first classifier, and having each subsequent classifier classify positive samples identified by a preceding classifier using a smaller sampling interval vector used for training said preceding classifier. Each classifier forms a union of its positive samples with those of the preceding classifier.
摘要:
A fetal parameter or anatomy is measured or detected from three-dimensional ultrasound data. An algorithm is machine-trained to detect fetal anatomy. Any machine training approach may be used. The machine-trained classifier is a joint classifier, such that one anatomy is detected using the ultrasound data and the detected location of another anatomy. The machine-trained classifier uses marginal space such that the location of anatomy is detected sequentially through translation, orientation and scale rather than detecting for all location parameters at once. The machine-trained classifier includes detectors for detecting from the ultrasound data at different resolutions, such as in a pyramid volume.
摘要:
A method for segmenting and measuring anatomical structures in fetal ultrasound images includes the steps of providing a digitized ultrasound image of a fetus comprising a plurality of intensities corresponding to a domain of points on a 3-dimensional grid, providing a plurality of classifiers trained to detect anatomical structures in said image of said fetus, and segmenting and measuring an anatomical structure using said image classifiers by applying said elliptical contour classifiers to said fetal ultrasound image, wherein a plurality of 2-dimensional contours characterizing said anatomical structure are detected. The anatomical structure measurement can be combined with measurement of another anatomical structure to estimate gestational age of the fetus.
摘要:
A fetal parameter or anatomy is measured or detected from three-dimensional ultrasound data. An algorithm is machine-trained to detect fetal anatomy. Any machine training approach may be used. The machine-trained classifier is a joint classifier, such that one anatomy is detected using the ultrasound data and the detected location of another anatomy. The machine-trained classifier uses marginal space such that the location of anatomy is detected sequentially through translation, orientation and scale rather than detecting for all location parameters at once. The machine-trained classifier includes detectors for detecting from the ultrasound data at different resolutions, such as in a pyramid volume.
摘要:
A method for segmenting and measuring anatomical structures in fetal ultrasound images includes the steps of providing a digitized ultrasound image of a fetus comprising a plurality of intensities corresponding to a domain of points on a 3-dimensional grid, providing a plurality of classifiers trained to detect anatomical structures in said image of said fetus, and segmenting and measuring an anatomical structure using said image classifiers by applying said elliptical contour classifiers to said fetal ultrasound image, wherein a plurality of 2-dimensional contours characterizing said anatomical structure are detected. The anatomical structure measurement can be combined with measurement of another anatomical structure to estimate gestational age of the fetus.
摘要:
A system operating in a plurality of modes to provide an integrated analysis of molecular data, imaging data, and clinical data associated with a patient includes a multi-scale model, a molecular model, and a linking component. The multi-scale model is configured to generate one or more estimated multi-scale parameters based on the clinical data and the imaging data when the system operates in a first mode, and generate a model of organ functionality based on one or more inferred multi-scale parameters when the system operates in a second mode. The molecular model is configured to generate one or more first molecular findings based on a molecular network analysis of the molecular data, wherein the molecular model is constrained by the estimated parameters when the system operates in the first mode. The linking component, which is operably coupled to the multi-scale model and the molecular model, is configured to transfer the estimated multi-scale parameters from the multi-scale model to the molecular model when the system operates in the first mode, and generate, using a machine learning process, the inferred multi-scale parameters based on the molecular findings when the system operates in the second mode.
摘要:
A method and system for fusion of multi-modal volumetric images is disclosed. A first image acquired using a first imaging modality is received. A second image acquired using a second imaging modality is received. A model and of a target anatomical structure and a transformation are jointly estimated from the first and second images. The model represents a model of the target anatomical structure in the first image and the transformation projects a model of the target anatomical structure in the second image to the model in the first image. The first and second images can be fused based on estimated transformation.
摘要:
Method and system for computation of advanced heart measurements from medical images and data; and therapy planning using a patient-specific multi-physics fluid-solid heart model is disclosed. A patient-specific anatomical model of the left and right ventricles is generated from medical image patient data. A patient-specific computational heart model is generated based on the patient-specific anatomical model of the left and right ventricles and patient-specific clinical data. The computational model includes biomechanics, electrophysiology and hemodynamics. To generate the patient-specific computational heart model, initial patient-specific parameters of an electrophysiology model, initial patient-specific parameters of a biomechanics model, and initial patient-specific computational fluid dynamics (CFD) boundary conditions are marginally estimated. A coupled fluid-structure interaction (FSI) simulation is performed using the initial patient-specific parameters, and the initial patient-specific parameters are refined based on the coupled FSI simulation. The estimated model parameters then constitute new advanced measurements that can be used for decision making.
摘要:
A method and system for automated view planning for cardiac magnetic resonance imaging (MRI) acquisition is disclosed. The method and system automatically generate a full scan prescription using a single 3D MRI volume. The left ventricle (LV) is segmented in the 3D MRI volume. Cardiac landmarks are detected in the automatically prescribed slices. A full scan prescription, including a short axis stack and 2-chamber, 3-chamber, and 4-chamber views, is automatically generated based on cardiac anchors provided by the segmented left ventricle and the detected cardiac landmarks in the 3D MRI volume.