公开(公告)号：US20110142811A1

公开(公告)日：2011-06-16

申请号：US12639536

申请日：2009-12-16

申请人： Guy UNGERECHTS ,  Christof Von Kalle ,  Sascha Bossow

发明人： Guy UNGERECHTS ,  Christof Von Kalle ,  Sascha Bossow

IPC分类号： C12N7/01 ,  C12N15/45 ,  C12N15/86 ,  C12N5/00 ,  A61K35/76 ,  A61K48/00 ,  A61P35/04

CPC分类号： A61K38/45 ,  A61K35/768 ,  C07K14/005 ,  C07K2319/30 ,  C12N2760/18422 ,  C12N2760/18432 ,  C12N2760/18443 ,  C12N2810/859 ,  A61K2300/00

摘要： The present invention concerns recombinant measles virus as a therapeutic, in particular a recombinant measles virus comprising a suicide gene in its genome, a mutated viral hemagglutinin, and a specificity domain specifically recognizing a cancer antigen. Furthermore, it relates to a polynucleotide coding for such a recombinant measles virus and a vector comprising said polynucleotide. The current invention also relates to a method for the manufacture of and a medicament comprising said recombinant measles virus, as well as a method for treating a solid tumor using said recombinant measles virus.

摘要翻译： 本发明涉及作为治疗剂的重组麻疹病毒，特别是其基因组中包含自杀基因的重组麻疹病毒，突变的病毒血凝素和特异性识别癌抗原的特异性结构域。 此外，它涉及编码这种重组麻疹病毒的多核苷酸和包含所述多核苷酸的载体。 本发明还涉及制备包含所述重组麻疹病毒的药物的方法以及使用所述重组麻疹病毒治疗实体瘤的方法。