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公开(公告)号：US20110142811A1
公开(公告)日：2011-06-16
申请号：US12639536
申请日：2009-12-16
CPC分类号： A61K38/45 , A61K35/768 , C07K14/005 , C07K2319/30 , C12N2760/18422 , C12N2760/18432 , C12N2760/18443 , C12N2810/859 , A61K2300/00
摘要： The present invention concerns recombinant measles virus as a therapeutic, in particular a recombinant measles virus comprising a suicide gene in its genome, a mutated viral hemagglutinin, and a specificity domain specifically recognizing a cancer antigen. Furthermore, it relates to a polynucleotide coding for such a recombinant measles virus and a vector comprising said polynucleotide. The current invention also relates to a method for the manufacture of and a medicament comprising said recombinant measles virus, as well as a method for treating a solid tumor using said recombinant measles virus.
摘要翻译： 本发明涉及作为治疗剂的重组麻疹病毒，特别是其基因组中包含自杀基因的重组麻疹病毒，突变的病毒血凝素和特异性识别癌抗原的特异性结构域。 此外，它涉及编码这种重组麻疹病毒的多核苷酸和包含所述多核苷酸的载体。 本发明还涉及制备包含所述重组麻疹病毒的药物的方法以及使用所述重组麻疹病毒治疗实体瘤的方法。
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2.发明授权Determination of in vivo DNA double-strand break localization and application thereof 有权体内DNA双链断裂定位及其应用的测定公开(公告)号：US09493827B2
公开(公告)日：2016-11-15
申请号：US13522225
申请日：2011-01-13
申请人： Christof Von Kalle , Manfred Schmidt , Richard Gabriel , Ali Nowrouzi , Anne Arens , Angelo Lombardo , Luigi Naldini
发明人： Christof Von Kalle , Manfred Schmidt , Richard Gabriel , Ali Nowrouzi , Anne Arens , Angelo Lombardo , Luigi Naldini
CPC分类号： C12Q1/686 , C12N15/907 , C12N2740/15021 , C12N2740/15031 , C12N2740/15045 , C12Q1/6827 , C12Q1/6858 , C12Q1/70 , C12Q2521/301
摘要： The present invention relates to a method for determining the in vivo localization of double-strand breaks in a host cell, comprising incubating a host cell suspected to comprise DNA double-strand breaks and a linear polynucleotide comprising a known sequence, detecting the in vivo insertion sites of said polynucleotide in the genome of said host cell, and assessing the in vivo localization of double-strand breaks. Further envisaged by the present invention is a method for obtaining an endonuclease with altered in vivo specificity. Finally, the present invention is directed to a kit for determining in vivo specificity of an endonuclease.
摘要翻译： 本发明涉及用于确定宿主细胞中双链断裂的体内定位的方法，包括孵育疑似包含DNA双链断裂的宿主细胞和包含已知序列的线性多核苷酸，检测体内插入 所述多核苷酸在所述宿主细胞的基因组中的位点，以及评估双链断裂的体内定位。 本发明进一步设想的是获得具有改变的体内特异性的核酸内切酶的方法。 最后，本发明涉及用于确定内切核酸酶的体内特异性的试剂盒。
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3.发明申请DETERMINATION OF IN VIVO DNA DOUBLE-STRAND BREAK LOCALIZATION AND APPLICATION THEREOF 有权VIVO DNA双重断裂定位及其应用的确定公开(公告)号：US20130143204A1
公开(公告)日：2013-06-06
申请号：US13522225
申请日：2011-01-13
申请人： Christof Von Kalle , Manfred Schmidt , Richard Gabriel , Ali Nowrouzi , Anne Arens , Angelo Lombardo , Luigi Naldini
发明人： Christof Von Kalle , Manfred Schmidt , Richard Gabriel , Ali Nowrouzi , Anne Arens , Angelo Lombardo , Luigi Naldini
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12N15/907 , C12N2740/15021 , C12N2740/15031 , C12N2740/15045 , C12Q1/6827 , C12Q1/6858 , C12Q1/70 , C12Q2521/301
摘要： The present invention relates to a method for determining the in vivo localization of double-strand breaks in a host cell, comprising incubating a host cell suspected to comprise DNA double-strand breaks and a linear polynucleotide comprising a known sequence, detecting the in vivo insertion sites of said polynucleotide in the genome of said host cell, and assessing the in vivo localization of double-strand breaks. Further envisaged by the present invention is a method for obtaining an endonuclease with altered in vivo specificity. Finally, the present invention is directed to a kit for determining in vivo specificity of an endonuclease.
摘要翻译： 本发明涉及用于确定宿主细胞中双链断裂的体内定位的方法，包括孵育疑似包含DNA双链断裂的宿主细胞和包含已知序列的线性多核苷酸，检测体内插入 所述多核苷酸在所述宿主细胞的基因组中的位点，以及评估双链断裂的体内定位。 本发明进一步设想的是获得具有改变的体内特异性的核酸内切酶的方法。 最后，本发明涉及用于确定内切核酸酶的体内特异性的试剂盒。
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