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公开(公告)号：US20090041725A1
公开(公告)日：2009-02-12
申请号：US11836322
申请日：2007-08-09
CPC分类号： C12N15/86 , A61K48/00 , C12N2770/36143
摘要： The present invention relates to a genome-replication-deficient and transcription-competent negative-strand RNA virus, which can be used for the expression of transgenes and in particular for the area of vaccine development.
摘要翻译： 本发明涉及可用于表达转基因，特别是疫苗开发领域的基因组复制缺陷型和转录主义的负链RNA病毒。
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公开(公告)号：US09795643B2
公开(公告)日：2017-10-24
申请号：US14719906
申请日：2015-05-22
申请人： Ulrich M. Lauer , Michael Bitzer , Johanna Lampe , Martina Schell , Susanne Berchtold , Sebastian Lange , Wolfgang J. Neubert , Sascha Bossow
发明人： Ulrich M. Lauer , Michael Bitzer , Johanna Lampe , Martina Schell , Susanne Berchtold , Sebastian Lange , Wolfgang J. Neubert , Sascha Bossow
IPC分类号： A61K35/768 , C12N9/10 , C12N9/78 , A61K31/7088 , C12N7/00
CPC分类号： A61K35/768 , A61K31/7088 , C07K2319/00 , C12N7/00 , C12N9/1077 , C12N9/78 , C12N2760/18421 , C12N2760/18432 , C12N2760/18443 , C12N2760/18471 , C12N2830/60 , C12Y305/04001
摘要： The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.
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公开(公告)号：US09272008B2
公开(公告)日：2016-03-01
申请号：US13818053
申请日：2011-08-19
申请人： Ulrich M. Lauer , Michael Bitzer , Johanna Lampe , Martina Zimmermann , Susanne Berchtold , Sebastian Lange , Wolfgang J. Neubert , Sascha Bossow
发明人： Ulrich M. Lauer , Michael Bitzer , Johanna Lampe , Martina Zimmermann , Susanne Berchtold , Sebastian Lange , Wolfgang J. Neubert , Sascha Bossow
IPC分类号： C12N7/00 , A61K39/165 , A61K39/00 , A61K35/768 , C12N9/10 , C12N9/78 , A61K31/7088
CPC分类号： A61K35/768 , A61K31/7088 , C07K2319/00 , C12N7/00 , C12N9/1077 , C12N9/78 , C12N2760/18421 , C12N2760/18432 , C12N2760/18443 , C12N2760/18471 , C12N2830/60 , C12Y305/04001
摘要： The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.
摘要翻译： 本发明涉及一种药物组合物，其包含编码自杀基因的重组麻疹病毒，所述重组麻疹病毒用于治疗具有抗自由基基因活性的溶瘤性麻疹病毒的一级或二级抗性的恶性细胞。 此外，本发明涉及基于编码自杀基因的麻疹疫苗株Schwarz的重组麻疹病毒，其包含胞嘧啶脱氨酶，特别是酵母胞嘧啶脱氨酶和尿嘧啶磷酸核糖转移酶，特别是酵母尿嘧啶磷酸核糖转移酶的融合物，其方法和 用于制备本文所要求的重组麻疹病毒的试剂盒。
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公开(公告)号：US20150250838A1
公开(公告)日：2015-09-10
申请号：US14719906
申请日：2015-05-22
申请人： Ulrich M. LAUER , Michael BITZER , Johanna LAMPE , Martina ZIMMERMANN , Susanne BERCHTOLD , Sebastian LANGE , Wolfgang J. NEUBERT , Sascha BOSSOW
发明人： Ulrich M. LAUER , Michael BITZER , Johanna LAMPE , Martina ZIMMERMANN , Susanne BERCHTOLD , Sebastian LANGE , Wolfgang J. NEUBERT , Sascha BOSSOW
IPC分类号： A61K35/768 , C12N9/78 , C12N7/00
CPC分类号： A61K35/768 , A61K31/7088 , C07K2319/00 , C12N7/00 , C12N9/1077 , C12N9/78 , C12N2760/18421 , C12N2760/18432 , C12N2760/18443 , C12N2760/18471 , C12N2830/60 , C12Y305/04001
摘要： The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.
摘要翻译： 本发明涉及一种药物组合物，其包含编码自杀基因的重组麻疹病毒，所述重组麻疹病毒用于治疗具有抗自由基基因活性的溶瘤性麻疹病毒的一级或二级抗性的恶性细胞。 此外，本发明涉及基于编码自杀基因的麻疹疫苗株Schwarz的重组麻疹病毒，其包含胞嘧啶脱氨酶，特别是酵母胞嘧啶脱氨酶和尿嘧啶磷酸核糖转移酶，特别是酵母尿嘧啶磷酸核糖转移酶的融合物，其方法和 用于制备本文所要求的重组麻疹病毒的试剂盒。
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公开(公告)号：US20130217757A1
公开(公告)日：2013-08-22
申请号：US13818053
申请日：2011-08-19
申请人： Ulrich M. Lauer , Michael Bitzer , Johanna Lampe , Martina Zimmermann , Susanne Berchtold , Sebastian Lange , Wolfgang J. Neubert , Sascha Bossow
发明人： Ulrich M. Lauer , Michael Bitzer , Johanna Lampe , Martina Zimmermann , Susanne Berchtold , Sebastian Lange , Wolfgang J. Neubert , Sascha Bossow
IPC分类号： A61K31/7088
CPC分类号： A61K35/768 , A61K31/7088 , C07K2319/00 , C12N7/00 , C12N9/1077 , C12N9/78 , C12N2760/18421 , C12N2760/18432 , C12N2760/18443 , C12N2760/18471 , C12N2830/60 , C12Y305/04001
摘要： The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.
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公开(公告)号：US20110142811A1
公开(公告)日：2011-06-16
申请号：US12639536
申请日：2009-12-16
CPC分类号： A61K38/45 , A61K35/768 , C07K14/005 , C07K2319/30 , C12N2760/18422 , C12N2760/18432 , C12N2760/18443 , C12N2810/859 , A61K2300/00
摘要： The present invention concerns recombinant measles virus as a therapeutic, in particular a recombinant measles virus comprising a suicide gene in its genome, a mutated viral hemagglutinin, and a specificity domain specifically recognizing a cancer antigen. Furthermore, it relates to a polynucleotide coding for such a recombinant measles virus and a vector comprising said polynucleotide. The current invention also relates to a method for the manufacture of and a medicament comprising said recombinant measles virus, as well as a method for treating a solid tumor using said recombinant measles virus.
摘要翻译： 本发明涉及作为治疗剂的重组麻疹病毒，特别是其基因组中包含自杀基因的重组麻疹病毒，突变的病毒血凝素和特异性识别癌抗原的特异性结构域。 此外，它涉及编码这种重组麻疹病毒的多核苷酸和包含所述多核苷酸的载体。 本发明还涉及制备包含所述重组麻疹病毒的药物的方法以及使用所述重组麻疹病毒治疗实体瘤的方法。
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