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公开(公告)号：US09127005B2
公开(公告)日：2015-09-08
申请号：US13386397
申请日：2010-07-23
IPC分类号： A61K31/438 , C07D471/10
CPC分类号： C07D471/10
摘要： Disclosed are isoform selective Phospholipase D inhibitors. In one aspect, the disclosed compounds can have a structure represented by a formula (I): Also disclosed are methods of making and using the compounds. Also disclosed are pharmaceutical compositions and kits comprising the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了同工型选择性磷脂酶D抑制剂。 一方面，所公开的化合物可以具有由式（I）表示的结构：还公开了制备和使用该化合物的方法。 还公开了包含该化合物的药物组合物和试剂盒。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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公开(公告)号：US20120214832A1
公开(公告)日：2012-08-23
申请号：US13386397
申请日：2010-07-23
IPC分类号： A61K31/438 , A61P35/00 , C07D471/10
CPC分类号： C07D471/10
摘要： Disclosed are isoform selective Phospholipase D inhibitors. In one aspect, the disclosed compounds can have a structure represented by a formula (I): Also disclosed are methods of making and using the compounds. Also disclosed are pharmaceutical compositions and kits comprising the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了同工型选择性磷脂酶D抑制剂。 一方面，所公开的化合物可以具有由式（I）表示的结构：还公开了制备和使用该化合物的方法。 还公开了包含该化合物的药物组合物和试剂盒。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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公开(公告)号：US20150025041A1
公开(公告)日：2015-01-22
申请号：US14348036
申请日：2012-09-30
申请人： Craig W. Lindsley , H. Alex Brown
发明人： Craig W. Lindsley , H. Alex Brown
IPC分类号： C07D471/10 , A61K31/435 , C07D401/04 , A61K31/498 , C07D401/14 , C07D405/14 , C07D409/14 , A61K31/4709 , A61K45/06 , A61K31/454
CPC分类号： C07D471/10 , A61K31/05 , A61K31/138 , A61K31/231 , A61K31/435 , A61K31/4535 , A61K31/454 , A61K31/4709 , A61K31/498 , A61K31/661 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , A61K2300/00 , A61K31/683
摘要： Disclosed are methods of treating viral infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to antiviral therapies. For example, compounds having Phospholipase D activity (e.g., isoform selective Phospholipase D inhibitors) can be useful in antiviral therapies (e.g., influenza treatments).
摘要翻译： 公开了治疗病毒感染的方法，其一方面包括施用作为磷脂酶D抑制剂的化合物。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。 根据本发明的目的，如本文中体现和广泛描述的，本发明在一个方面涉及抗病毒疗法。 例如，具有磷脂酶D活性的化合物（例如，同种型选择性磷脂酶D抑制剂）可用于抗病毒疗法（例如流感病毒治疗）。
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4.发明授权Benzisoxazoles and azabenzisoxazoles as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction 有权作为MGLUR4变构增强剂的苯并异恶唑和氮杂苯并恶唑，组合物和治疗神经功能障碍的方法公开(公告)号：US08916584B2
公开(公告)日：2014-12-23
申请号：US13578802
申请日：2011-02-11
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
IPC分类号： C07D498/04 , C07D491/048 , A61K31/42 , A61K31/423 , A61K31/4355 , A61K31/437 , A61K45/06 , C07D261/20
CPC分类号： C07D498/04 , A61K31/42 , A61K31/423 , A61K31/4355 , A61K31/437 , A61K45/06 , C07D261/20 , C07D491/048
摘要： Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的苯并异恶唑和氮杂苯并恶唑化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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5.发明申请SUBSTITUTED IMIDAZOPYRIMIDIN-5(6H)-ONES AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS 有权作为MGLUR5受体的独立调节因子的取代的咪达霉素-5（6H）公开(公告)号：US20130245043A1
公开(公告)日：2013-09-19
申请号：US13420333
申请日：2012-03-14
申请人： P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , José Manuel Bartolomé-Nebreda , Gregor James MacDonald , Susana Conde-Ceide , Carrie K. Jones , María Luz Martín-Martín , Han Min Tong
发明人： P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , José Manuel Bartolomé-Nebreda , Gregor James MacDonald , Susana Conde-Ceide , Carrie K. Jones , María Luz Martín-Martín , Han Min Tong
IPC分类号： A61K31/519 , A61P25/00 , A61P25/28 , A61P25/18 , A61P25/30 , A61P25/14 , A61P25/08 , A61P25/06 , A61P3/10 , A61P3/04 , A61P25/20 , A61P25/22 , A61P25/24 , A61P35/00 , C07D487/04
CPC分类号： C07D487/04
摘要： In one aspect, the invention relates to imidazopyrimidin-5(6H)-one analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及可用作代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂的咪唑并嘧啶-5（6H） - 酮类似物及其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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6.发明授权Substituted phenylamine carboxamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same 失效取代的苯胺甲酰胺类似物作为mGluR5负变构调节剂及其制备和使用方法公开(公告)号：US08501757B2
公开(公告)日：2013-08-06
申请号：US12885420
申请日：2010-09-17
申请人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates , Brian A. Chauder
发明人： P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates , Brian A. Chauder
IPC分类号： A61K31/505 , A61K31/44 , C07D239/02 , C07D403/12 , C07D401/12 , C07D213/62 , A61K31/4965
CPC分类号： A61K31/4406 , A61K31/497 , C07D401/12 , C07D401/14
摘要： Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 公开了代谢型谷氨酸受体亚型5（mGluR5）的负变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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7.发明申请Heterocyclic Sulfone MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction 有权杂环砜MGLUR4变构电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20130158078A1
公开(公告)日：2013-06-20
申请号：US13697783
申请日：2011-05-12
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M Niswender , Rocco D. Gogliotti , James M. Salovich , Darren W. Engers , Yiu-Yin Cheung
IPC分类号： A61K31/4439 , A61K45/06 , C07D417/12
CPC分类号： A61K31/4439 , A61K45/06 , C07D401/12 , C07D413/12 , C07D417/12
摘要： Heterocyclic sulfone compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的杂环砜化合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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8.发明申请Benzisoxazoles and Azabenzisoxazoles as MGLUR4 Allosteric Potentiators, Compositions, and Methods of Treating Neurological Dysfunction 有权苯并恶唑和偶氮苯并恶唑作为MGLUR4变构电位器，组合物和治疗神经功能障碍的方法公开(公告)号：US20130079366A1
公开(公告)日：2013-03-28
申请号：US13578802
申请日：2011-02-11
申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
发明人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender , Darren W. Engers
IPC分类号： C07D498/04 , A61K31/437 , A61K31/423 , A61K45/06 , C07D261/20 , C07D491/048 , A61K31/4355
CPC分类号： C07D498/04 , A61K31/42 , A61K31/423 , A61K31/4355 , A61K31/437 , A61K45/06 , C07D261/20 , C07D491/048
摘要： Benzisoxazole and azabenzisoxazole compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
摘要翻译： 可用作代谢型谷氨酸受体亚型4（mGluR4）的变构增强子/正变构调节剂的苯并异恶唑和氮杂苯并恶唑化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物的方法，例如，用于治疗神经和精神疾病或与谷氨酸功能障碍相关的其它疾病状态。
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9.发明申请BICYCLIC TRIAZOLE AND PYRAZOLE LACTAMS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS 失效作为MGLUR5受体的独立调节剂的双相三唑和吡唑类公开(公告)号：US20120225844A1
公开(公告)日：2012-09-06
申请号：US13329025
申请日：2011-12-16
申请人： P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , José Manuel Bartolomé-Nebreda , Susana Conde-Ceide , Gregor James Macdonald , Han Min Tong , Carrie K. Jones , Manuel Jesús Alcázar-Vaca , José Ignacio Andrés-Gil , Chrysa Malosh
发明人： P. Jeffrey Conn , Craig W. Lindsley , Shaun R. Stauffer , José Manuel Bartolomé-Nebreda , Susana Conde-Ceide , Gregor James Macdonald , Han Min Tong , Carrie K. Jones , Manuel Jesús Alcázar-Vaca , José Ignacio Andrés-Gil , Chrysa Malosh
IPC分类号： C07D487/04 , A61K31/695 , C07F7/08 , A61P35/04 , A61P25/20 , A61P25/18 , A61P25/08 , A61P25/28 , A61P25/06 , A61K31/4985 , A61P25/00
CPC分类号： C07D487/04 , A61K31/40 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/695 , A61K45/06 , C07F7/1804
摘要： In one aspect, the invention relates to bicyclic triazole and pyrazole lactams, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及双代三唑和吡唑内酰胺，其衍生物和相关化合物，其可用作代谢型谷氨酸受体亚型5（mGluR5）的正变构调节剂; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与谷氨酸官能障碍相关的神经和精神障碍的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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10.发明授权公开(公告)号：US08211933B2
公开(公告)日：2012-07-03
申请号：US12636099
申请日：2009-12-11
IPC分类号： A61K31/4035 , C07D209/44
CPC分类号： C07D209/52 , C07D403/12
摘要： In one aspect, the invention relates to compounds which are useful as as inhibitors of glycine type 1 transporter (GlyT1) activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with glycine type 1 transporter (GlyT1) activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译： 一方面，本发明涉及作为甘氨酸1型转运蛋白（GlyT1）活性的抑制剂有用的化合物; 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗与甘氨酸1型转运蛋白（GlyT1）活性相关的病症的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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