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    EXTRACORPOREAL CELL-BASED THERAPEUTIC DEVICE AND DELIVERY SYSTEM
    2.
    发明申请
    EXTRACORPOREAL CELL-BASED THERAPEUTIC DEVICE AND DELIVERY SYSTEM 审中-公开
    基于细胞的细胞治疗设备和递送系统

    公开(公告)号：US20110190679A1

    公开(公告)日：2011-08-04

    申请号：US13027481

    申请日：2011-02-15

    申请人： H. David Humes ,  Deborah Buffington ,  Gretchen Hageman

    发明人： H. David Humes ,  Deborah Buffington ,  Gretchen Hageman

    IPC分类号： A61M1/36 ,  A61M1/28 ,  C12N5/00

    CPC分类号： A61M1/3687 ,  A61K35/12 ,  A61K35/22 ,  A61M1/3689

    摘要： Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in response to a dynamic physiologic environment. One embodiment includes long hollow fibers in which a layer of cells are grown within the intraluminal volume or within a double hollow-filled chamber. Another embodiment includes a wafer or a series of wafers providing a substrate onto which cells are grown. The wafer(s) are inserted into a device. A device may deliver a pre-selected molecule, for example, a hormone, into a mammal's systemic circulation and/or may deliver a member of different cell products. The device is adapted to secure viable cells which produce and secrete the pre-selected molecule into blood or fluid. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel or body cavity the device of the invention.

    摘要翻译： 公开了基于体外细胞的治疗装置和递送系统，其提供了响应于动态生理环境而由活细胞产生的生物活性分子的治疗递送的方法。 一个实施方案包括长的中空纤维，其中细胞层在腔内体积内生长或在双重中空填充的室内生长。 另一个实施例包括晶片或一系列晶片，其提供生长细胞的基底。 将晶片插入设备中。 装置可以将预先选择的分子例如激素递送到哺乳动物的体循环中和/或可以递送不同细胞产物的成员。 该装置适于将产生和分泌预先选择的分子的活细胞固定到血液或流体中。 本发明还提供了一种用于经皮引入本发明的装置的预选血管或体腔的微创方法。