公开(公告)号：US09708280B2

公开(公告)日：2017-07-18

申请号：US14744197

申请日：2015-06-19

Applicant: H. Lundbeck A/S

Inventor： Thomas Ruhland ,  Garrick Paul Smith ,  Benny Bang-Andersen ,  Ask Puschl ,  Ejner Knud Moltzen ,  Kim Andersen

IPC: C07D295/096 ,  C07D295/145 ,  C07D211/20 ,  C07D211/70 ,  C07D243/08 ,  C07D295/033

CPC classification number: C07D295/145 ,  C07D211/20 ,  C07D211/70 ,  C07D243/08 ,  C07D295/033 ,  C07D295/096

Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

公开(公告)号：US09353073B2

公开(公告)日：2016-05-31

申请号：US14767350

申请日：2014-02-20

Applicant: H. Lundbeck A/S

Inventor： Thomas Ruhland ,  Kim Lasse Christensen

IPC: C07D295/096 ,  C07F15/02

CPC classification number: C07D295/096 ,  C07F15/02

Abstract: A process for the manufacture of vortioxetine is provided in which a compound of formula I, formula I is reacted with optionally substituted piperazine and 2,4-dimethylthiophenol(ate) followed by de-cmplexation.

Abstract translation: 提供了一种制备伏妥托汀的方法，其中式I式I化合物与任选取代的哌嗪和2,4-二甲基苯硫酚（ate）反应，随后进行去络合。

公开(公告)号：US20140163043A1

公开(公告)日：2014-06-12

申请号：US13927678

申请日：2013-06-26

Applicant: H. Lundbeck A/S

Inventor： Thomas Ruhland ,  Garrick P. Smith ,  Benny Bang-Andersen ,  Ask Puschl ,  Ejner K. Moltzen ,  Kim Andersen

IPC: C07D295/096

CPC classification number: C07D295/145 ,  C07D211/20 ,  C07D211/70 ,  C07D243/08 ,  C07D295/033 ,  C07D295/096

Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

Abstract translation: 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。

公开(公告)号：US20180127389A1

公开(公告)日：2018-05-10

申请号：US15624417

申请日：2017-06-15

Applicant: H. Lundbeck A/S

Inventor： Thomas Ruhland ,  Garrick Paul Smith ,  Benny Bang-Andersen ,  Ask Puschl ,  Ejner Knud Moltzen ,  Kim Andersen

IPC: C07D295/145 ,  C07D295/033 ,  C07D211/20 ,  C07D243/08 ,  C07D211/70 ,  C07D295/096

CPC classification number: C07D295/145 ,  C07D211/20 ,  C07D211/70 ,  C07D243/08 ,  C07D295/033 ,  C07D295/096

Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

公开(公告)号：US20160137620A1

公开(公告)日：2016-05-19

申请号：US14744197

申请日：2015-06-19

Applicant: H. Lundbeck A/S

Inventor： Thomas Ruhland ,  Garrick Paul Smith ,  Benny Bang-Andersen ,  Ask Puschl ,  Ejner Knud Moltzen ,  Kim Andersen

IPC: C07D295/145 ,  C07D295/033

CPC classification number: C07D295/145 ,  C07D211/20 ,  C07D211/70 ,  C07D243/08 ,  C07D295/033 ,  C07D295/096

Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

Abstract translation: 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。

公开(公告)号：US20160009670A1

公开(公告)日：2016-01-14

申请号：US14767350

申请日：2014-02-20

Applicant: H. LUNDBECK A/S

Inventor： Thomas Ruhland ,  Kim Lasse Christensen

IPC: C07D295/096 ,  C07F15/02

CPC classification number: C07D295/096 ,  C07F15/02

Abstract: A process for the manufacture of vortioxetine is provided in which a compound of formula I, formula I is reacted with optionally substituted piperazine and 2,4-dimethylthiophenol(ate) followed by de-complexation.

Abstract translation: 提供了一种制备伏妥托汀的方法，其中式I式I化合物与任选取代的哌嗪和2,4-二甲基苯硫酚（ate）反应，随后脱络合。

公开(公告)号：US20210276966A1

公开(公告)日：2021-09-09

申请号：US17078055

申请日：2020-10-22

Applicant: H. Lundbeck A/S

Inventor： Thomas Ruhland ,  Garrick Paul Smith ,  Benny Bang-Andersen ,  Ask Puschl ,  Ejner Knud Moltzen ,  Kim Andersen

IPC: C07D295/145 ,  C07D211/20 ,  C07D211/70 ,  C07D243/08 ,  C07D295/096 ,  C07D295/033

Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

公开(公告)号：US09090575B2

公开(公告)日：2015-07-28

申请号：US13927678

申请日：2013-06-26

Applicant: H. Lundbeck A/S

Inventor： Thomas Ruhland ,  Garrick P. Smith ,  Benny Bang-Andersen ,  Ask Puschl ,  Ejner K. Moltzen ,  Kim Andersen

IPC: C07D295/096 ,  C07D211/20 ,  C07D211/70 ,  C07D243/08

CPC classification number: C07D295/145 ,  C07D211/20 ,  C07D211/70 ,  C07D243/08 ,  C07D295/033 ,  C07D295/096

Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

Abstract translation: 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。