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公开(公告)号:US09393248B1
公开(公告)日:2016-07-19
申请号:US15071955
申请日:2016-03-16
发明人: Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC分类号: A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497
CPC分类号: A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要: The present invention is directed to aminopyridine derived compounds of formula (A) The compounds are considered useful for the treatment of diseases associated with LRRK2 such as a Lewy body dementia, Parkinson's disease or cancer.
摘要翻译: 本发明涉及衍生自式(A)的氨基吡啶衍生化合物。该化合物被认为可用于治疗与LRRK2相关的疾病,例如路易体痴呆,帕金森病或癌症。
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公开(公告)号:US20160184317A1
公开(公告)日:2016-06-30
申请号:US15071955
申请日:2016-03-16
发明人: Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC分类号: A61K31/5377 , A61K31/4545 , A61K31/497 , A61K31/4439
CPC分类号: A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要: The present invention is directed to aminopyridine derived compounds of formula (A) The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
摘要翻译: 本发明涉及衍生自式(A)的氨基吡啶衍生化合物。该化合物被认为可用于治疗与LRRK2相关的疾病如路易体痴呆,帕金森病或癌症。
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公开(公告)号:US09321748B2
公开(公告)日:2016-04-26
申请号:US14758884
申请日:2013-12-30
发明人: Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC分类号: C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
CPC分类号: A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要: The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
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公开(公告)号:US09708280B2
公开(公告)日:2017-07-18
申请号:US14744197
申请日:2015-06-19
申请人: H. Lundbeck A/S
发明人: Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号: C07D295/096 , C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033
CPC分类号: C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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公开(公告)号:US20210276966A1
公开(公告)日:2021-09-09
申请号:US17078055
申请日:2020-10-22
申请人: H. Lundbeck A/S
发明人: Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号: C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/096 , C07D295/033
摘要: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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公开(公告)号:US20180127389A1
公开(公告)日:2018-05-10
申请号:US15624417
申请日:2017-06-15
申请人: H. Lundbeck A/S
发明人: Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号: C07D295/145 , C07D295/033 , C07D211/20 , C07D243/08 , C07D211/70 , C07D295/096
CPC分类号: C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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公开(公告)号:US20160137620A1
公开(公告)日:2016-05-19
申请号:US14744197
申请日:2015-06-19
申请人: H. Lundbeck A/S
发明人: Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号: C07D295/145 , C07D295/033
CPC分类号: C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译: 本发明提供由通式I表示的化合物,其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍,包括抑郁症,焦虑症,包括一般焦虑症,惊恐障碍和强迫症。
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公开(公告)号:US20150336942A1
公开(公告)日:2015-11-26
申请号:US14758884
申请日:2013-12-30
发明人: Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC分类号: C07D413/14 , C07D403/14
CPC分类号: A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
摘要: The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
摘要翻译: 本发明涉及氨基吡啶衍生的式(A)化合物。 该化合物被认为可用于治疗与LRRK2相关的疾病如路易体痴呆,帕金森病或癌症。
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