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公开(公告)号：US09393248B1
公开(公告)日：2016-07-19
申请号：US15071955
申请日：2016-03-16
Applicant: H. Lundbeck A/S , Vernalis (R&D) Ltd.
Inventor： Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC: A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497
CPC classification number: A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
Abstract: The present invention is directed to aminopyridine derived compounds of formula (A) The compounds are considered useful for the treatment of diseases associated with LRRK2 such as a Lewy body dementia, Parkinson's disease or cancer.
Abstract translation: 本发明涉及衍生自式（A）的氨基吡啶衍生化合物。该化合物被认为可用于治疗与LRRK2相关的疾病，例如路易体痴呆，帕金森病或癌症。
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公开(公告)号：US20160184317A1
公开(公告)日：2016-06-30
申请号：US15071955
申请日：2016-03-16
Applicant: H. Lundbeck A/S , Vernalis (R&D) Ltd.
Inventor： Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC: A61K31/5377 , A61K31/4545 , A61K31/497 , A61K31/4439
CPC classification number: A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
Abstract: The present invention is directed to aminopyridine derived compounds of formula (A) The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
Abstract translation: 本发明涉及衍生自式（A）的氨基吡啶衍生化合物。该化合物被认为可用于治疗与LRRK2相关的疾病如路易体痴呆，帕金森病或癌症。
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公开(公告)号：US09321748B2
公开(公告)日：2016-04-26
申请号：US14758884
申请日：2013-12-30
Applicant: H. Lundbeck A/S , Vernalis (R&D) Ltd.
Inventor： Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC: C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
CPC classification number: A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
Abstract: The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
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Patent Agency Ranking
公开(公告)号：US09708280B2
公开(公告)日：2017-07-18
申请号：US14744197
申请日：2015-06-19
Applicant: H. Lundbeck A/S
Inventor： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC: C07D295/096 , C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033
CPC classification number: C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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公开(公告)号：US20180127389A1
公开(公告)日：2018-05-10
申请号：US15624417
申请日：2017-06-15
Applicant: H. Lundbeck A/S
Inventor： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC: C07D295/145 , C07D295/033 , C07D211/20 , C07D243/08 , C07D211/70 , C07D295/096
CPC classification number: C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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公开(公告)号：US20160137620A1
公开(公告)日：2016-05-19
申请号：US14744197
申请日：2015-06-19
Applicant: H. Lundbeck A/S
Inventor： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC: C07D295/145 , C07D295/033
CPC classification number: C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
Abstract translation: 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US20150336942A1
公开(公告)日：2015-11-26
申请号：US14758884
申请日：2013-12-30
Applicant: H. Lundbeck A/S , Vernalis (R&D) Ltd.
Inventor： Gitte Kobberøe Mikkelsen , Laurent David , Stephen Watson , Garrick Paul Smith , Douglas Stewart Williamson , I-Jen Chen
IPC: C07D413/14 , C07D403/14
CPC classification number: A61K31/5377 , A61K31/4439 , A61K31/4545 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14 , C07D413/04 , C07D413/14
Abstract: The present invention is directed to aminopyridine derived compounds of formula (A). The compounds are considered useful for the treatment of diseases associated with LRRK2 such a Lewy body dementia, Parkinson's disease or cancer.
Abstract translation: 本发明涉及氨基吡啶衍生的式（A）化合物。 该化合物被认为可用于治疗与LRRK2相关的疾病如路易体痴呆，帕金森病或癌症。
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公开(公告)号：US20210276966A1
公开(公告)日：2021-09-09
申请号：US17078055
申请日：2020-10-22
Applicant: H. Lundbeck A/S
Inventor： Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC: C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/096 , C07D295/033
Abstract: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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