公开(公告)号：US20180084982A1

公开(公告)日：2018-03-29

申请号：US15714048

申请日：2017-09-25

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Daisuke YAMASHITA ,  Yutaka YAMASHITA ,  Yukio UEDA ,  Yoshinori TAMAOKI

IPC: A61B1/07 ,  A61M25/00 ,  F21V8/00 ,  G02B6/10

Abstract: A device for radiating pulsed light toward a thrombus in a blood vessel includes a light source configured to output monitoring light to be radiated into the blood vessel, a light detector configured to detect returned light of the monitoring light and output a detection signal, and a computer configured to acquire a time waveform, which is a change in an intensity of the returned light over time, based on the detection signal, wherein the computer is configured to obtain a parameter on the basis of the time waveform and evaluates a reaction in the blood vessel according to the radiation of the pulsed light on the basis of the parameter.

公开(公告)号：US20190070608A1

公开(公告)日：2019-03-07

申请号：US16122048

申请日：2018-09-05

Applicant: HAMAMATSU PHOTONICS K.K. ,  NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE

Inventor： Hirotoshi KIKUCHI ,  Shigetoshi OKAZAKI ,  Hidenao YAMADA ,  Yusuke OZAKI ,  Amane HIROTSU ,  Daisuke YAMASHITA

IPC: B01L3/00 ,  G01N15/14

Abstract: A cell observation system observes a cell moving in a flow path with a fluid, and includes a first observation apparatus, a second observation apparatus, and a control device. The first observation apparatus includes an objective lens and a line camera. The second observation apparatus includes an objective lens and an area camera. The control device analyzes first imaging data output from the first observation apparatus to determine whether the cell satisfies a specific condition, instructs the area camera to output second imaging data of the cell determined to satisfy the specific condition, and analyzes the second imaging data output from the second observation apparatus to determine whether the cell is a specific cell.

公开(公告)号：US20220120660A1

公开(公告)日：2022-04-21

申请号：US17310813

申请日：2020-02-14

Applicant: NATIONAL UNIVERSITY CORPORATION HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE ,  HAMAMATSU PHOTONICS K.K.

Inventor： Hirotoshi KIKUCHI ,  Hidenao YAMADA ,  Amane HIROTSU ,  Daisuke YAMASHITA ,  Shigetoshi OKAZAKI

IPC: G01N15/14 ,  G02B21/36

Abstract: A cell observation system observes a cell moving in a flow path with a fluid, and includes a first imaging apparatus, a second imaging apparatus, and a control device. The first imaging apparatus includes a first optical system and a first imaging element, and captures an image of the cell at a first position in a moving direction. The second imaging apparatus includes a second optical system, in which a focus is adjusted based on a focus adjustment signal, and a second imaging element, and captures an image of the cell at a second position downstream of the first position. The control device obtains a passing position of the cell in a cross section of the flow path based on the image obtained by the first imaging element, generates the focus adjustment signal, and provides the signal to the second optical system.