公开(公告)号：US20150136986A1

公开(公告)日：2015-05-21

申请号：US14402570

申请日：2013-05-02

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Kouichiro Akiyama ,  Takashi Yasuda ,  Yoichi Kawada ,  Atsushi Nakanishi

IPC: G01N21/3586

CPC classification number: G01N21/3586 ,  G01N21/3581

Abstract: A prism member having an entrance surface for arranging a terahertz-wave generator for generating a terahertz wave in response to pump light incident thereon, an arrangement part for arranging an object to be measured, an exit surface for arranging a terahertz-wave detector for detecting a correlation between the terahertz wave transmitted through the object in the arrangement part and probe light, a first optical surface for collimating or condensing the terahertz wave incident thereon from the entrance surface toward the arrangement part, and a second optical surface for condensing the terahertz wave transmitted through the arrangement part toward the exit surface, the arrangement part forms a depression adapted to be filled with a liquid incapable of dissolving the object therein.

Abstract translation: 一种具有入射表面的棱镜构件，用于响应于入射到其上的泵浦光而产生太赫兹波的太赫兹波发生器，用于布置待测物体的布置部分，用于布置用于检测的太赫兹波检测器的出射表面 在配置部分中透过物体的太赫兹波与探测光之间的相关性，用于使入射表面朝向配置部分入射的太赫波的准直或聚光的第一光学表面和用于冷凝太赫兹波的第二光学表面 通过排列部分朝向出射表面透射，所述布置部分形成适于填充有不能将物体溶解在其中的液体的凹陷。

公开(公告)号：US10248003B2

公开(公告)日：2019-04-02

申请号：US15505963

申请日：2015-08-28

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Kouichiro Akiyama ,  Yoichi Kawada ,  Takashi Yasuda ,  Atsushi Nakanishi ,  Hironori Takahashi

IPC: G02F1/355 ,  G02F1/361 ,  C07D213/38 ,  C07D401/04 ,  G01N21/3581 ,  C07C309/30

Abstract: Disclosed is a non-linear optical crystal containing pyridinium represented by the following Formula (1), 4-substituted phenylsulfonate represented by the following Formula (2a), and 2,4,6-substituted phenylsulfonate represented by the following Formula (2b).

公开(公告)号：US11293859B2

公开(公告)日：2022-04-05

申请号：US16701242

申请日：2019-12-03

Applicant: HAMAMATSU PHOTONICS K.K. ,  National Institute of Health Sciences

Inventor： Kouichiro Akiyama ,  Kazuki Horita ,  Hironori Takahashi ,  Hiroshi Satozono ,  Tomoaki Sakamoto

IPC: G01N21/3581 ,  G01N21/55 ,  G01N33/02

Abstract: A fermentation state monitoring apparatus includes: a terahertz wave generation element that outputs inspection light using a terahertz wave to a fermented food under fermentation in a sealed product container; a terahertz wave detection element that detects return light of the inspection light reflected by the fermented food in the product container; and a determination unit that determines a fermentation progress of the fermented food based on an index value including a reflectance of the return light with respect to the inspection light or an absorption coefficient of the return light with respect to the inspection light.

公开(公告)号：US09417182B2

公开(公告)日：2016-08-16

申请号：US14402570

申请日：2013-05-02

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Kouichiro Akiyama ,  Takashi Yasuda ,  Yoichi Kawada ,  Atsushi Nakanishi

IPC: G01N21/35 ,  G01N21/3586 ,  G01N21/3581

CPC classification number: G01N21/3586 ,  G01N21/3581

Abstract: A prism member having an entrance surface for arranging a terahertz-wave generator for generating a terahertz wave in response to pump light incident thereon, an arrangement part for arranging an object to be measured, an exit surface for arranging a terahertz-wave detector for detecting a correlation between the terahertz wave transmitted through the object in the arrangement part and probe light, a first optical surface for collimating or condensing the terahertz wave incident thereon from the entrance surface toward the arrangement part, and a second optical surface for condensing the terahertz wave transmitted through the arrangement part toward the exit surface, the arrangement part forms a depression adapted to be filled with a liquid incapable of dissolving the object therein.

Abstract translation: 一种具有入射表面的棱镜构件，用于响应于入射到其上的泵浦光而产生太赫兹波的太赫兹波发生器，用于布置待测物体的布置部分，用于布置用于检测的太赫兹波检测器的出射表面 在配置部分中透过物体的太赫兹波与探测光之间的相关性，用于使入射表面朝向配置部分入射的太赫波的准直或聚光的第一光学表面和用于冷凝太赫兹波的第二光学表面 通过排列部分朝向出射表面透射，所述布置部分形成适于填充有不能将物体溶解在其中的液体的凹陷。

公开(公告)号：US09157851B2

公开(公告)日：2015-10-13

申请号：US13742616

申请日：2013-01-16

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Gen Takebe ,  Yoichi Kawada ,  Kouichiro Akiyama

IPC: G01J5/02 ,  G01N21/3577 ,  G01N21/3563 ,  G01N21/3586

CPC classification number: G01N21/3577 ,  G01N21/3563 ,  G01N21/3586 ,  G01N21/552

Abstract: The drug evaluation device obtains, by an attenuated reflection method using a terahertz wave, an evaluation absorption spectrum for a frequency with respect to a liquid to be evaluated. When crystalline particles are suspended in a liquid, an absorption peak having a peak area corresponding to the amount of suspension appears in its absorption spectrum. Therefore, whether or not and by what ratio crystalline particles are suspended in the liquid can be determined according to whether or not the absorption peak exists and the peak area. When amorphous particles are suspended in the liquid, the baseline of its absorption spectrum lowers according to the ratio of amorphous particles suspended in the liquid. Therefore, whether or not and by what ratio amorphous particles are suspended in the liquid can be determined according to the lowering amount of the baseline.

Abstract translation: 药物评价装置通过使用太赫兹波的衰减反射法获得关于待评价液体的频率的评价吸收光谱。 当结晶颗粒悬浮在液体中时，具有对应于悬浮液量的峰面积的吸收峰出现在其吸收光谱中。 因此，可以根据是否存在吸收峰和峰面积来确定晶体颗粒悬浮在液体中的比例和比例。 当无定形颗粒悬浮在液体中时，其吸收光谱的基线根据悬浮在液体中的无定形颗粒的比例而降低。 因此，可以根据基线的降低量来确定无定形颗粒是否悬浮在液体中的比例。

公开(公告)号：US11774357B2

公开(公告)日：2023-10-03

申请号：US17474338

申请日：2021-09-14

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Kazuhiro Takahashi ,  Kouichiro Akiyama ,  Hiroshi Satozono

IPC: G01N21/35 ,  G01N21/3563 ,  G01N21/552

CPC classification number: G01N21/3563 ,  G01N21/552

Abstract: A terahertz wave attenuated total reflection spectroscopic method, includes: a first step of disposing a measurement target of which a volume is changed during a measurement period on a reflection surface; and a second step of acquiring data including a plurality of detection results respectively corresponding to a plurality of times separated from each other during the measurement period by allowing a terahertz wave to be incident on the reflection surface from a side opposite to the measurement target and by detecting the terahertz wave reflected on the reflection surface, during the measurement period. In the second step, a state in which a substantially constant pressure is applied to the measurement target disposed on the reflection surface is maintained during the measurement period.

公开(公告)号：US09128041B2

公开(公告)日：2015-09-08

申请号：US13742616

申请日：2013-01-16

Applicant: Hamamatsu Photonics K.K.

Inventor： Gen Takebe ,  Yoichi Kawada ,  Kouichiro Akiyama

IPC: G01J5/02 ,  G01N21/3577 ,  G01N21/3563 ,  G01N21/3586

Abstract: The drug evaluation device obtains, by an attenuated reflection method using a terahertz wave, an evaluation absorption spectrum for a frequency with respect to a liquid to be evaluated. When crystalline particles are suspended in a liquid, an absorption peak having a peak area corresponding to the amount of suspension appears in its absorption spectrum. Therefore, whether or not and by what ratio crystalline particles are suspended in the liquid can be determined according to whether or not the absorption peak exists and the peak area. When amorphous particles are suspended in the liquid, the baseline of its absorption spectrum lowers according to the ratio of amorphous particles suspended in the liquid. Therefore, whether or not and by what ratio amorphous particles are suspended in the liquid can be determined according to the lowering amount of the baseline.