公开(公告)号：US20250003873A1

公开(公告)日：2025-01-02

申请号：US18703745

申请日：2022-09-29

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Osamu YASUHIKO ,  Kozo TAKEUCHI ,  Hidenao YAMADA

IPC: G01N21/45 ,  G02B21/14 ,  G02B21/36

Abstract: An observation apparatus includes a light source, a mirror, a condenser lens, an objective lens, a beam splitter, an imaging unit, and an analysis unit. The analysis unit includes an interference intensity image acquisition unit, a first complex amplitude image generation unit, a second complex amplitude image generation unit, a two-dimensional phase image generation unit, a three-dimensional phase image generation unit, a refractive index distribution calculation unit, and a third complex amplitude image generation unit. The analysis unit irradiates an observation object with light along each of a plurality of light irradiation directions by changing an orientation of a reflection surface of the mirror, acquires an interference intensity image for each of the plurality of light irradiation directions from the imaging unit, and performs necessary processing based on the interference intensity images to obtain a three-dimensional refractive index distribution of the observation object.

公开(公告)号：US20250052678A1

公开(公告)日：2025-02-13

申请号：US18713756

申请日：2022-07-06

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Kozo TAKEUCHI ,  Osamu YASUHIKO ,  Hidenao YAMADA

IPC: G01N21/41

Abstract: A refractive index distribution evaluation method, evaluation device, and information processing program, comprising: a data acquisition step or a data acquisition unit for acquiring refractive index distribution data for an object of observation; a selection step or a selection unit for selecting whether a target included in the refractive index distribution data is an evaluation target; and an evaluation step or an evaluation unit for evaluating the refractive index distribution of the evaluation target.

公开(公告)号：US20240410825A1

公开(公告)日：2024-12-12

申请号：US18704137

申请日：2022-09-29

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Osamu YASUHIKO ,  Kozo TAKEUCHI ,  Hidenao YAMADA

IPC: G01N21/45 ,  G01N15/14 ,  G01N21/41

Abstract: An observation apparatus includes a light source, a beam splitter, a mirror, a mirror, a cylindrical lens, a lens, a cylindrical lens, a beam splitter, a lens, a frequency shifter, an imaging unit, and an analysis unit. The analysis unit generates a complex amplitude image of each of a plurality of light irradiation directions of object light based on time series data of an interference intensity image output from the imaging unit, and generates a three-dimensional complex differential interference image of an observation object based on the complex amplitude image of each of the plurality of light irradiation directions. The analysis unit obtains a three-dimensional phase image of the observation object based on the three-dimensional complex differential interference image.

公开(公告)号：US20230324296A1

公开(公告)日：2023-10-12

申请号：US18024996

申请日：2021-01-21

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Osamu YASUHIKO ,  Kozo TAKEUCHI ,  Hidenao YAMADA

IPC: G01N21/45 ,  G01N21/88 ,  G01N21/47

CPC classification number: G01N21/45 ,  G01N21/8851 ,  G01N21/4795 ,  G01N2021/1787

Abstract: An observation apparatus includes a light source, a mirror, a condenser lens, an objective lens, a beam splitter, an imaging unit, and an analysis unit. The analysis unit includes an interference intensity image acquisition unit, a first complex amplitude image generation unit, a second complex amplitude image generation unit, a two-dimensional phase image generation unit, a three-dimensional phase image generation unit, and a refractive index distribution calculation unit. The analysis unit irradiates an observation object with light along each of a plurality of light irradiation directions, acquires an interference intensity image at a reference position for each of the plurality of light irradiation directions from the imaging unit, and performs necessary processing based on the interference intensity images to obtain a three-dimensional refractive index distribution of the observation object.

公开(公告)号：US20250123201A1

公开(公告)日：2025-04-17

申请号：US18703751

申请日：2022-09-29

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Osamu YASUHIKO ,  Kozo TAKEUCHI ,  Hidenao YAMADA

IPC: G01N21/45 ,  G02B21/36

Abstract: An observation apparatus includes a light source, a mirror, a condenser lens, an objective lens, a beam splitter, an imaging unit, and an analysis unit. The analysis unit includes an interference intensity image acquisition unit, a first complex amplitude image generation unit, a second complex amplitude image generation unit, a phase conjugate operation unit, a two-dimensional phase image generation unit, a three-dimensional phase image generation unit, and a refractive index distribution calculation unit. The analysis unit irradiates an observation object with light along each of a plurality of light irradiation directions by changing an orientation of a reflection surface of the mirror, acquires an interference intensity image at a reference position for each of the plurality of light irradiation directions from the imaging unit, and performs necessary processing based on the interference intensity images to obtain a three-dimensional phase image of the observation object.

公开(公告)号：US20230252606A1

公开(公告)日：2023-08-10

申请号：US18009054

申请日：2021-05-24

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Osamu YASUHIKO ,  Kozo TAKEUCHI

IPC: G06T5/00

CPC classification number: G06T5/002 ,  G06T2207/10056

Abstract: In a noise estimation step, a noise image included in a target image including linear noises extending along a first direction is estimated. In this case, an evaluation function including a first term representing a difference between a result obtained by performing differentiation processing in a second direction and low frequency component extraction processing in the first direction on the target image and a result obtained by performing differentiation processing in the second direction and low frequency component extraction processing in the first direction on the noise image is used to obtain the noise image which minimizes a value of the evaluation function. In a noise reduction step, a noise reduced image is generated from the target image based on the target image and the noise image.

公开(公告)号：US20230152206A1

公开(公告)日：2023-05-18

申请号：US17917044

申请日：2021-03-03

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Osamu YASUHIKO ,  Kozo TAKEUCHI

IPC: G01N15/14 ,  G02B21/06 ,  G02B21/36

CPC classification number: G01N15/1434 ,  G02B21/06 ,  G02B21/361 ,  G01N2015/1497 ,  G01N2015/1006

Abstract: An observation apparatus includes a light source, a lens, a polarizer, a first prism, a condenser lens, an objective lens, a second prism, a ¼ wave plate, a lens, a polarization camera, and an analysis unit. Each of the first prism and the second prism is, for example, a Wollaston prism or a Nomarski prism. The ¼ wave plate inputs light output from the second prism, and outputs two circularly polarized light beams having different rotation directions. The polarization camera inputs two light beams being circularly polarized in different rotation directions by the ¼ wave plate, and acquires an interference image on an imaging plane for each of three or more polarization components.