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公开(公告)号：US20170227468A1
公开(公告)日：2017-08-10
申请号：US15499244
申请日：2017-04-27
发明人： Katsumi SHIBAYAMA , Masashi ITO , Takafumi YOKINO , Masaki HIROSE , Anna YOSHIDA , Kazuto OFUJI , Yoshihiro MARUYAMA
CPC分类号： G01N21/658 , B82Y40/00 , G01J3/02 , G01J3/0205 , G01J3/12 , G01J3/44 , G01J3/4412 , G01N2201/02 , G01N2201/0227 , G01N2201/06113
摘要： A SERS unit comprises a substrate; an optical function part formed on the substrate, for generating surface-enhanced Raman scattering; and a package containing the optical function part in an inert space and configured to irreversibly expose the space.
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公开(公告)号：US20230034756A1
公开(公告)日：2023-02-02
申请号：US17791280
申请日：2021-01-14
IPC分类号： G01N33/569 , G01N21/65
摘要： A cell analysis method includes a mixing step of mixing a cell as an analyte, a metal ion solution, and a reducing agent to prepare a mixture solution, a metal microstructure generation step of reducing metal ions in the mixture solution by reducing action of the reducing agent to generate a metal microstructure on a support, and attaching the cell or a cell-derived substance to the metal microstructure, a drying step of, after the metal microstructure generation step, drying the support, a measurement step of, after the drying step, irradiating the metal microstructure on the support with excitation light, and measuring a spectrum of Raman scattered light generated by the excitation light irradiation, and an analysis step of analyzing the cell based on the spectrum of the Raman scattered light.
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公开(公告)号：US20210181116A1
公开(公告)日：2021-06-17
申请号：US17263175
申请日：2019-07-16
摘要： An analyte analysis method includes, in one example, a mixing step of mixing an analyte, a metal ion solution, and a reducing agent to prepare a mixture solution, a metal microstructure generation step of reducing metal ions in the mixture solution by reducing action of the reducing agent in the mixture solution to generate a metal microstructure on a support, and attaching the analyte or a substance derived from the analyte to the metal microstructure, a measurement step of irradiating the metal microstructure on the support with excitation light, and measuring a spectrum of Raman scattered light generated by the excitation light irradiation, and an analysis step of analyzing the analyte based on the spectrum of the Raman scattered light.
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4.发明申请SURFACE-ENHANCED RAMAN SCATTERING UNIT AND RAMAN SPECTROSCOPIC ANALYSIS METHOD 有权表面增强拉曼散射单元和拉曼光谱分析方法公开(公告)号：US20160061736A1
公开(公告)日：2016-03-03
申请号：US14780728
申请日：2014-02-07
IPC分类号： G01N21/65
CPC分类号： G01N21/658
摘要： A SERS unit 1A comprises a SERS element 2 having a substrate and an optical function part 20 formed on the substrate, the optical function part 20 for generating surface-enhanced Raman scattering; a measurement board 3 supporting the SERS element 2 upon measurement; and a holding part 4 mechanically holding the SERS element 2 in the measurement board 3.
摘要翻译： SERS单元1A包括具有基板的SERS元件2和形成在基板上的光学功能部件20，用于产生表面增强拉曼散射的光学功能部件20; 在测量时支撑SERS元件2的测量板3; 以及将SERS元件2机械地保持在测量板3中的保持部4。
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公开(公告)号：US20180195966A1
公开(公告)日：2018-07-12
申请号：US15576435
申请日：2016-04-28
CPC分类号： G01N21/658 , G01J3/4412 , G01N2021/651 , G01N2201/068
摘要： An SERS unit includes a support 10 that includes a cavity 11 provided with an opening 12, an optical functional portion 20 that is disposed in the cavity 11 to face the opening 12 and causes surface enhanced Raman scattering, and a package 5 that accommodates the support 10 and is evacuated. The package 5 is in contact with at least an edge 12a of the opening 12, and is bent toward the optical functional portion 20 in a state in which the package 5 is spaced apart from the optical functional portion 20 in the opening 12.
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公开(公告)号：US20180136134A1
公开(公告)日：2018-05-17
申请号：US15553337
申请日：2016-02-10
发明人： Katsumi SHIBAYAMA , Masashi ITO , Kazuto OFUJI , Hiroki OYAMA , Yoshihiro MARUYAMA , Nao INOUE
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , B82Y40/00 , G01N2021/651
摘要： An SERS element includes a substrate, a fine structure portion formed on a surface of the substrate and having a plurality of pillars, and a conductor layer formed on the fine structure portion and constituting an optical functional portion that causes surface-enhanced Raman scattering. A groove is provided in an outer surface of each pillar. A plurality of gaps are formed in the conductor layer by forming the conductor layer on the outer surface of each pillar in a state in which at least a portion of an inner surface of the groove is exposed.
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公开(公告)号：US20170089838A1
公开(公告)日：2017-03-30
申请号：US15375720
申请日：2016-12-12
发明人： Katsumi SHIBAYAMA , Masashi ITO , Takafumi YOKINO , Masaki HIROSE , Anna YOSHIDA , Kazuto OFUJI , Yoshihiro MARUYAMA
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , B82Y40/00 , G01J3/02 , G01J3/12 , G01J3/44 , G01N2201/02 , G01N2201/0227 , G01N2201/06113
摘要： A SERS unit comprises a substrate; an optical function part formed on the substrate, for generating surface-enhanced Raman scattering; and a package containing the optical function part in an inert space and configured to irreversibly expose the space.
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8.发明申请SURFACE-ENHANCED RAMAN SCATTERING UNIT AND RAMAN SPECTROSCOPIC ANALYSIS METHOD 有权表面增强拉曼散射单元和拉曼光谱分析方法公开(公告)号：US20160061737A1
公开(公告)日：2016-03-03
申请号：US14780776
申请日：2014-02-07
IPC分类号： G01N21/65
CPC分类号： G01N21/658
摘要： A surface-enhanced Raman scattering unit comprises a measurement board used upon measurement; a surface-enhanced Raman scattering element, secured to the measurement board, having a substrate and an optical function part, formed on the substrate, for generating surface-enhanced Raman scattering; and a pressing member, secured to the measurement board, having a ring-shaped contact part contacting a peripheral part of the surface-enhanced Raman scattering element and pressing the surface-enhanced Raman scattering element toward the measurement board.
摘要翻译： 表面增强拉曼散射单元包括测量时使用的测量板; 表面增强拉曼散射元件，固定到测量板上，具有形成在基板上的用于产生表面增强拉曼散射的基板和光学功能部分; 以及固定在测量基板上的按压部件，具有与表面增强拉曼散射元件的周边部分接触并将表面增强拉曼散射元件朝测量基板按压的环状接触部。
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9.发明申请SURFACE-ENHANCED RAMAN SCATTERING UNIT AND RAMAN SPECTROSCOPIC ANALYSIS METHOD 有权表面增强拉曼散射单元和拉曼光谱分析方法公开(公告)号：US20160054227A1
公开(公告)日：2016-02-25
申请号：US14780755
申请日：2014-02-07
IPC分类号： G01N21/65
CPC分类号： G01N21/658 , B01L9/52 , B01L2200/18 , B01L2300/041 , B01L2300/0858 , G02B21/34
摘要： A SERS unit 1A comprises a SERS element 2 having a substrate 21 and an optical function part 20 formed on the substrate 21, the optical function part 20 for generating surface-enhanced Raman scattering; a transportation board 3 supporting the SERS element 2 during transportation, the SERS element 2 being removed from the transportation board 3 upon measurement; and a holding part 4 having a pinching part 41 pinching the SERS element 2 in cooperation with the transportation board 3, and detachably holding the SERS element 2 in the transportation board 3.
摘要翻译： SERS单元1A包括具有基板21和形成在基板21上的光学功能部分20的SERS元件2，用于产生表面增强拉曼散射的光学功能部分20; 在运输过程中支撑SERS元件2的运输板3，SERS元件2在测量时从运输板3上移除; 以及具有夹持部41的保持部4，该夹持部41与传送板3协作地夹持SERS元件2，并且将SERS元件2可拆卸地保持在输送板3中。
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公开(公告)号：US20220172045A1
公开(公告)日：2022-06-02
申请号：US17437871
申请日：2020-02-25
摘要： A convolutional neural network decision basis extraction apparatus includes a contribution rate calculation unit and a basis extraction unit. The contribution rate calculation unit obtains a contribution rate of a weight of a fully connected layer to an output label of an output layer. The basis extraction unit extracts a decision basis of a CNN based on a feature map input to the fully connected layer, the weight of the fully connected layer, and the above contribution rate.
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