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公开(公告)号：US20180215840A1
公开(公告)日：2018-08-02
申请号：US15322326
申请日：2016-06-01
发明人： Sung Chul CHOI , Hyun Il KIM , Ki Young YANG , Hyo Seung PARK , Back Ho LEE
CPC分类号： C08B37/0072 , A61K8/0241 , A61K8/735 , A61K9/0024 , A61K9/06 , A61K47/02 , A61K47/08 , A61K47/10 , A61K47/36 , A61L27/20 , A61L2400/06 , A61L2430/34 , A61Q19/08 , C08J3/24 , C08J2305/08 , C08L5/08 , C08L2205/025
摘要： Provided are a method of preparing a cross-linked hyaluronic acid having an elasticity of about 50 to about 200 Pa and a viscosity of about 20 to about 100 Pa, including cross-linking hyaluronic acid with an epoxy-based cross-linking agent having at least two epoxy functional groups in an ethanol-containing aqueous alkaline; a method of preparing a cross-linked hyaluronic acid having an elasticity of about 400 to about 800 Pa and a viscosity of about 40 to about 100 Pa, including cross-linking the same cross-linked hyaluronic acid with the same epoxy-based cross-linking agent in an aqueous alkaline solution; and a combination of the cross-linked hyaluronic acids one having an elasticity of about 50 to about 200 Pa and a viscosity of about 20 to about 100 Pa and the other having an elasticity of about 400 to about 800 Pa and a viscosity of about 40 to about 100 Pa.
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公开(公告)号：US20190315887A1
公开(公告)日：2019-10-17
申请号：US16448180
申请日：2019-06-21
发明人： Sung Chul CHOI , Hyun Il KIM , Ki Young YANG , Hyo Seung PARK , Back Ho LEE
IPC分类号： C08B37/08 , C08L5/08 , A61K9/00 , A61K47/02 , A61K47/08 , A61K47/36 , A61K8/02 , A61Q19/08 , A61K8/73 , C08J3/24 , A61L27/20 , A61K9/06 , A61K47/10
摘要： Provided are a combination of cross-linked hyaluronic acids comprising: a cross-linked hyaluronic acid having an elasticity of about 50 to about 200 Pa and a viscosity of about 20 to about 100 Pa, and a cross-linked hyaluronic acid having an elasticity of about 400 to about 800 Pa and a viscosity of about 40 to about 100 Pa, and a method for preparing the same.
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